Toxicity evaluation of monodisperse PEGylated magnetic nanoparticles for nanomedicine

Patsula, Vitalii; Tulinská, Jana; Trachtová, Štěpánka; Kuricová, Miroslava; Líšková, Aurélia; Španová, Alena; Cĭampor, F; Vávra, I.; Rittich, Bohuslav; Ursı́nyová, Monika; Dušinská, Maria; Ilavská, Silvia; Horváthová, Mira; Mašánová, Vlasta; Uhnáková, Iveta

doi:10.1080/17435390.2018.1555624

Cited by 18 publications

(12 citation statements)

References 56 publications

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“…A variety of carrier systems have been tested for delivery of PAs, including liposomes, polymer-based nanoparticles, microbubbles, and magnetic nanoparticles (MNPs) etc., with different advantages and disadvantages [5,6]. It is generally considered that lipid-bilayer structured liposomes [5,7] or cell-derived carriers [8] are most biocompatible, whereas the biocompatibility of polymeric nanoparticles and MNPs may depend on the characteristics of the polymers as the coating materials [9]. In addition to biocompatibility, the coating materials also provide better colloidal stability and functional groups for immobilization of targeting ligands or PAs.…”

Section: Design and Preparation Of Rtpa Nanocompositesmentioning

confidence: 99%

“…In addition to biocompatibility, the coating materials also provide better colloidal stability and functional groups for immobilization of targeting ligands or PAs. The iron oxide (Fe 3 O 4 or γ-Fe 2 O 3 ) core of MNPs with superparamagnetic properties enables magnetic separation and magnetic capture in a drug delivery system [9].…”

Section: Design and Preparation Of Rtpa Nanocompositesmentioning

confidence: 99%

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Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation

Liu

Liang

et al. 2019

Molecules

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In thrombolytic therapy, plasminogen activators (PAs) are still the only group of drug approved to induce thrombolysis, and therefore, critical for treatment of arterial thromboembolism, such as stroke, in the acute phase. Functionalized nanocomposites have attracted great attention in achieving target thrombolysis due to favorable characteristics associated with the size, surface properties and targeting effects. Many PA-conjugated nanocomposites have been prepared and characterized, and some of them has been demonstrated with therapeutic efficacy in animal models. To facilitate future translation, this paper reviews recent progress of this area, especially focus on how to achieve reproducible thrombolysis efficacy in vivo.

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Section: Design and Preparation Of Rtpa Nanocompositesmentioning

confidence: 99%

Section: Design and Preparation Of Rtpa Nanocompositesmentioning

confidence: 99%

Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation

Liu

Liang

et al. 2019

Molecules

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“…28,29 Among the different available synthetic techniques for the preparation of MNPs, thermal decomposition provides the greatest control over the structural characteristics and physical properties of the obtained NPs. 30 However, its most important drawback is to obtain MNPs that possess a hydrophobic coating, which makes the particles only stable in low polarity media. Therefore, a subsequent surface modification process is required to transfer these MNPs to aqueous-based biological environments.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

et al. 2020

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Magnetic nanoparticles (MNPs) are one of the most promising candidates for their use as theranostic agents in the biomedical field due to their potential as contrast agents in magnetic resonance imaging (MRI) and also as heat generators in magnetic hyperthermia treatments. However, despite the large number of publications about this topic, just some few systematic studies about the influence of MNPs composition on their theranostic capabilities have been carried out. In this work, we show a detailed methodology for the preparation of highly monodisperse iron oxide-based MNPs with different cobalt, zinc, and manganese doping extents in the superparamagnetic regime. We aim to provide the tools to control the composition of the particles, as well as for their functionalization to make them highly stable in biological-mimicking media. Procedures to measure the capability of the particles as magnetothermal and MRI negative contrast agents as well as to analyze the influence of doping on such properties are also reported. In all experiments, the applied alternating magnetic fields were within the maximum allowed amplitude, frequency, and amplitude·frequency product range for potential validation of the experimental data toward the potential translation of the present MNPs to the clinical practice.

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“…A biocompatibility assessment is a crucial factor prior to any in vivo application of hybrid NPs. ,− A number of reports indicate that polymers can enhance biocompatibility and decrease the cytotoxicity of inorganic NPs. ,, To date, very few studies have examined the in vitro and in vivo toxicity of RAFT polymers alone. In 2010, Bulmus, Maynard, and their co-workers reported the first comprehensive investigation of cytotoxicity of frequently used RAFT polymers prepared using different dithiobenzoate or trithiocarbonate RAFT agents.…”

Section: Properties Of Nanohybrids Endowed With Polymersmentioning

confidence: 99%

Engineering Organic/Inorganic Nanohybrids through RAFT Polymerization for Biomedical Applications

Huang

et al. 2019

Biomacromolecules

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Despite many early accomplishments in nanomaterial design and synthesis, there remains a significant requirement for novel inorganic and organic nanohybrids with the potential to act as efficacious molecular imaging agents and theranostic vectors. The functionalization of surfactantcoated inorganic nanoparticles with polymer shells represents one of the most suitable and popular methods to synthesize polymer/inorganic nanohybrids for theranostic applications. Key requirements for effective imaging agent design include water dispersibility, biocompatibility and functionality to enable enhanced contrast magnetic resonance imaging (MRI), positron-emission tomography (PET), computed tomography (CT), or ultrasound modalities. In this Perspective, we highlight recent advances in the fabrication of organic/inorganic nanohybrids exploiting functionalized polymers prepared using reversible addition−fragmentation chain transfer (RAFT) polymerization. The polymer shells can imbue favorable traits to the nanoparticles such as stealth, image enhancement, storage (and release) of therapeutics, and sensitivity to biological stimuli. In this Perspective, we discuss the design and synthesis of hybrid nanoparticles and discuss current trends and future opportunities.

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Toxicity evaluation of monodisperse PEGylated magnetic nanoparticles for nanomedicine

Cited by 18 publications

References 56 publications

Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation

Targeted Delivery of Plasminogen Activators for Thrombolytic Therapy: An Integrative Evaluation

Synthesis, Characterization, and Evaluation of Superparamagnetic Doped Ferrites as Potential Therapeutic Nanotools

Engineering Organic/Inorganic Nanohybrids through RAFT Polymerization for Biomedical Applications

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