Toxicity assessment of parabens in Caenorhabditis elegans

Nagar, Yogendra; Thakur, Ravindra Singh; Parveen, Tuba; Patel, Devendra Kumar; Ram, K. Ravi; Satish, A.

doi:10.1016/j.chemosphere.2019.125730

Cited by 67 publications

(22 citation statements)

References 71 publications

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“…Parabens, such as ethylparaben, are used as a preservative in food, personal care products, and pharmaceuticals, and are continuously released into the environment. Concerns regarding the safety of parabens in humans and the environment are increasing, with toxicity reported in Caenorhabditis elegans models [ 68 ]. It does not appear that any studies focused on the possible relationship between TFMPP and/or paraben exposure and PD development have been published to date.…”

Section: Resultsmentioning

confidence: 99%

Studying the Parkinson’s disease metabolome and exposome in biological samples through different analytical and cheminformatics approaches: a pilot study

et al. 2022

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Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, with an increasing incidence in recent years due to the aging population. Genetic mutations alone only explain <10% of PD cases, while environmental factors, including small molecules, may play a significant role in PD. In the present work, 22 plasma (11 PD, 11 control) and 19 feces samples (10 PD, 9 control) were analyzed by non-target high-resolution mass spectrometry (NT-HRMS) coupled to two liquid chromatography (LC) methods (reversed-phase (RP) and hydrophilic interaction liquid chromatography (HILIC)). A cheminformatics workflow was optimized using open software (MS-DIAL and patRoon) and open databases (all public MSP-formatted spectral libraries for MS-DIAL, PubChemLite for Exposomics, and the LITMINEDNEURO list for patRoon). Furthermore, five disease-specific databases and three suspect lists (on PD and related disorders) were developed, using PubChem functionality to identifying relevant unknown chemicals. The results showed that non-target screening with the larger databases generally provided better results compared with smaller suspect lists. However, two suspect screening approaches with patRoon were also good options to study specific chemicals in PD. The combination of chromatographic methods (RP and HILIC) as well as two ionization modes (positive and negative) enhanced the coverage of chemicals in the biological samples. While most metabolomics studies in PD have focused on blood and cerebrospinal fluid, we found a higher number of relevant features in feces, such as alanine betaine or nicotinamide, which can be directly metabolized by gut microbiota. This highlights the potential role of gut dysbiosis in PD development.

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Section: Resultsmentioning

confidence: 99%

Studying the Parkinson’s disease metabolome and exposome in biological samples through different analytical and cheminformatics approaches: a pilot study

et al. 2022

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“…However, the greater the length of the alkyl chain, the higher the lipid solubility, which leads to a high rate of penetration of parabens through the epidermis [5]. Humans are mainly exposed to parabens through skin absorption and ingestion of personal care products, but parabens have also been detected in the natural environment, including in indoor dust, the surface water of rivers, sediment, and sludge [6]. Other studies have reported parabens in human tissue and urine [7,8].…”

Section: Introductionmentioning

confidence: 99%

Butylparaben Is Toxic to Porcine Oocyte Maturation and Subsequent Embryonic Development Following In Vitro Fertilization

Jeong

Lee

Park

et al. 2020

IJMS

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Parabens are widely used in personal care products due to their antimicrobial effects. Although the toxicity of parabens has been reported, little information is available on the toxicity of butylparaben (BP) on oocyte maturation. Therefore, we investigated the effects of various concentrations of BP (0 μM, 100 μM, 200 μM, 300 μM, 400 μM, and 500 μM) on the in vitro maturation of porcine oocytes. BP supplementation at a concentration greater than 300 μM significantly reduced the proportion of complete cumulus cell expansion and metaphase II oocytes compared to the control. The 300 μM BP significantly decreased fertilization, cleavage, and blastocyst formation rates with lower total cell numbers and a higher rate of apoptosis in blastocysts compared to the control. The BP-treated oocytes showed significantly higher reactive oxygen species (ROS) levels, and lower glutathione (GSH) levels than the control. BP significantly increased the aberrant mitochondrial distribution and decreased mitochondrial function compared to the control. BP-treated oocytes exhibited significantly higher percentage of γ-H2AX, annexin V-positive oocytes and expression of LC3 than the control. In conclusion, we demonstrated that BP impaired oocyte maturation and subsequent embryonic development, by inducing ROS generation and reducing GSH levels. Furthermore, BP disrupted mitochondrial function and triggered DNA damage, early apoptosis, and autophagy in oocytes.

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“…There are many types of preservatives, including parabens, formaldehyde releasers, isothiazolinones, phenoxyethanol, and organic As by far the most widely abused preservatives worldwide, paraben is a class of low-toxicity and high-efficiency preservatives. They were first reported to have antibacterial activity in 1924 and have been used for more than 80 years [6]. The mechanism of action of parabens is to change the permeability of cell membranes and cell walls so that enzymes and metabolites in microorganisms can escape.…”

Section: Introductionmentioning

confidence: 99%

A rapid and environmentally friendly method for determination of parabens preservatives in flavors by supercritical fluid chromatography‐tandem mass spectrometry

Yang

Dong

Zhang

et al. 2022

J of Separation Science

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A rapid method for determination of parabens preservatives (methyl paraben, ethyl paraben, isopropyl paraben, propyl paraben, isobutyl paraben, and butyl paraben) in flavors was established by using supercritical fluid chromatographytandem mass spectrometry combined with dispersive solid-phase extraction.After adding methanol and primary secondary amine to the sample simultaneously, high extraction efficiency and good sample cleanup could be obtained by simple shaking. Parabens were well separated on a Chiralpak IG-3 column in 6 min by gradient elution. Recoveries from spiked blank samples at 0.5, 1.0, and 5.0 mg/kg were determined to be 88.3-106.6%with relative standard deviations less than 8.0%. All analytes achieved good linear relation (r ≥ 0.999 2). The limits of detection for all analytes ranged from 0.03 to 0.09 mg/kg and the limits of quantification from 0.11 to 0.31 mg/kg, respectively. A total of 20 actual samples were successfully analyzed by taking the proposed method. Being simple, rapid, green, and reliable, this method can be taken for the determination of parabens preservatives in flavors.

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Toxicity assessment of parabens in Caenorhabditis elegans

Cited by 67 publications

References 71 publications

Studying the Parkinson’s disease metabolome and exposome in biological samples through different analytical and cheminformatics approaches: a pilot study

Studying the Parkinson’s disease metabolome and exposome in biological samples through different analytical and cheminformatics approaches: a pilot study

Butylparaben Is Toxic to Porcine Oocyte Maturation and Subsequent Embryonic Development Following In Vitro Fertilization

A rapid and environmentally friendly method for determination of parabens preservatives in flavors by supercritical fluid chromatography‐tandem mass spectrometry

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