Toxicity and sublethal effects of methylparaben on zebrafish (Danio rerio) larvae and adults

Penha, Larissa Cristine de Carvalho; Rola, Regina Coimbra; Silva, Flávio Manoel da; Martins, Camila de Martinez Gaspar

doi:10.1007/s11356-021-12800-5

Cited by 20 publications

(3 citation statements)

References 51 publications

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“…Due to the lack of available ecotoxicological data for sea urchins, an additional toxicity assessment of the candidates was based on the acute toxicity values (EC 50 and LC 50 ) reported in the literature for fish and invertebrates ( Table S3 ). The effects of the individual compounds observed in this study are in line with the results reported in other studies [ 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 ], online available databases (Pesticides Properties Database, PPDB, , accessed on 2 May 2022) and estimated values with Ecological Structure–Activity Relationship (ECOSAR) modelling (version 2.0, downloaded from , accessed on 29 April 2022) since the EC 50 and LC 50 values are much higher than the calculated concentrations of the compounds. In any case, as can be observed in Table S3 , EDDP (0.000032 mg/L) was ranked at the top of the list of toxicants for invertebrates, followed by TEP (0.02 mg/L) and 2,4-DBT (0.281 mg/L), fenpropidin (0.54 mg/L), isoproturon (0.58 mg/L), eprosartan (0.593 mg/L) and propranolol (0.8 mg/L) to a lesser extent.…”

Section: Resultssupporting

confidence: 93%

Suspect Screening of Chemicals in Hospital Wastewaters Using Effect-Directed Analysis Approach as Prioritization Strategy

et al. 2023

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The increasing number of contaminants in the environment has pushed water monitoring programs to find out the most hazardous known and unknown chemicals in the environment. Sample treatment-simplification methods and non-target screening approaches can help researchers to not overlook potential chemicals present in complex aqueous samples. In this work, an effect-directed analysis (EDA) protocol using the sea urchin embryo test (SET) as a toxicological in vivo bioassay was used as simplified strategy to identify potential unknown chemicals present in a very complex aqueous matrix such as hospital effluent. The SET bioassay was used for the first time here to evaluate potential toxic fractions in hospital effluent, which were obtained after a two-step fractionation using C18 and aminopropyl chromatographic semi-preparative columns. The unknown compounds present in the toxic fractions were identified by means of liquid chromatography coupled to a Q Exactive Orbitrap high-resolution mass spectrometer (LC-HRMS) and using a suspect analysis approach. The results were complemented by gas chromatography-mass spectrometry analysis (GC-MS) in order to identify the widest range of chemical compounds present in the sample and the toxic fractions. Using EDA as sample treatment simplification method, the number of unknown chemicals (>446 features) detected in the raw sample was narrowed down to 94 potential toxic candidates identified in the significantly toxic fractions. Among them, the presence of 25 compounds was confirmed with available chemical standards including 14 pharmaceuticals, a personal care product, six pesticides and four industrial products. The observations found in this work emphasize the difficulties in identifying potential toxicity drivers in complex water samples, as in the case of hospital wastewater.

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Section: Resultssupporting

confidence: 93%

Suspect Screening of Chemicals in Hospital Wastewaters Using Effect-Directed Analysis Approach as Prioritization Strategy

et al. 2023

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“…Albanit et al [ 18 ] stated that BHT likely cause similar effects on marine organisms. MeP is widely used in cosmetic products [ 68 ] and is considered toxic to both zebrafish larvae and adults [ 69 ], as it can cause oxidative stress and endocrine disruption [ 70 ]. Methyl acrylate (MA), identified by Py–GC/MS in white glitter [ 18 ], has also been reported to be toxic to fish and invertebrates [ 71 ].…”

Section: Discussionmentioning

confidence: 99%

A Glow before Darkness: Toxicity of Glitter Particles to Marine Invertebrates

Abessa,

Albanit,

Moura

et al. 2023

Toxics

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Glitter particles are considered a model of microplastics, which are used in a wide range of products. In this study, we evaluated the toxicity of two types of glitter (green and white, with distinct chemical compositions) dispersions on the embryonic development of the sea urchins Echinometra lucunte, Arbacia lixula, and the mussel Perna perna. The Toxicity Identification and Evaluation (TIE) approach was used to identify possible chemicals related to toxicity. Glitter dispersions were prepared using 0.05% ethanol. The tested dispersions ranged from 50 to 500 mg/L. The white glitter was composed of a vinyl chloride–methyl acrylate copolymer. The effective concentrations of green glitter to 50% embryos (EC50) were 246.1 (235.8–256.4) mg/L to A. lixula, 23.0 (20.2–25.8) mg/L to P. perna and 105.9 (61.2–150.2) mg/L, whereas the EC50 of white glitter to E. lucunter was 272.2 (261.5–282.9) mg/L. The EC50 for P. perna could not be calculated; however, the lowest effect concentration was 10 mg/L—that was the lowest concentration tested. The filtered suspension of green glitter had Ag levels exceeding the legal standards for marine waters. TIE showed that metals, volatiles, and oxidant compounds contribute to toxicity. The results showed that glitter may adversely affect marine organisms; however, further studies are necessary to determine its environmental risks.

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“…widely reported [30,[37][38][39]. However, the risk of parabens on coastal ecosystems remains questionable, since the formation of degradation products on aquatic media, as well as the response of marine aquatic (non-target) species are not fully elucidated and are poorly understood.…”

Section: Of 21mentioning

confidence: 99%

Methyl- and Propyl-Paraben Differential Toxic Potential on the Bacterium Aliivibrio fischeri and Marine Bivalve Mollusks: First Evidence for Their Adverse Effects on Mussel Mytilus galloprovincialis

Dailianis¹,

Vlastos²,

Zoppou³

et al. 2023

Preprint

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This study investigated methyl- (MeP) and propyl- (PrP) adverse effects on the bacterium Aliivibrio fischeri (using the Bioluminescence Inhibition/Microtox® bioassay) and the marine bivalve mollusk Mytilus galloprovincialis (in terms of mussel mortality, cellular, oxidative and genotoxic stress indices). Specifically, although the assessment of MeP and PrP behavior into aquatic media (artificial sea water/ASW and 2% NaCl), primarily performed by UHPLC-UV-MS analysis, showed only a slight hydrolysis of PrP to 4-HBA in ASW, both species exposure to different concentrations of each paraben revealed differences among MeP and PrP toxic potential. Interestingly, the Microtox® bioassay showed that PrP mediated toxicity in Aliivibrio fischeri were more pronounced than MeP in all periods tested (5 and 15 min). Similar findings were also observed in hemocytes of mussels exposed for 4 days to 0.3 and 2 μg L-1 of each compound, as revealed by the disturbance of mussel hemocytes’ lysosomal membrane integrity, the enhanced levels of superoxides, nitric oxides, and lipid peroxidation byproducts, as well as the formation of micronuclei. These findings are of great interest, since MeP and PrP differential toxic potential, as well their ability to induce pre-pathological alterations in marine species, like mussels give new evidence for their risk to aquatic biota.

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Toxicity and sublethal effects of methylparaben on zebrafish (Danio rerio) larvae and adults

Cited by 20 publications

References 51 publications

Suspect Screening of Chemicals in Hospital Wastewaters Using Effect-Directed Analysis Approach as Prioritization Strategy

Suspect Screening of Chemicals in Hospital Wastewaters Using Effect-Directed Analysis Approach as Prioritization Strategy

A Glow before Darkness: Toxicity of Glitter Particles to Marine Invertebrates

Methyl- and Propyl-Paraben Differential Toxic Potential on the Bacterium Aliivibrio fischeri and Marine Bivalve Mollusks: First Evidence for Their Adverse Effects on Mussel Mytilus galloprovincialis

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