Toxicity and aluminium concentration in bone following dietary administration of two sodium aluminium phosphate formulations in rats

Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese

“…A study was conducted by Stauffer Chemical Company in male rats fed their basic SALP-containing products. The treatment groups ate feed for 28 days containing: 3% KASAL (1866 mg Al/kg diet; ~ daily dose 141 mg/kg bw), 0.7% KASAL II (908 mg Al/kg diet; ~ daily dose 67 mg Al/ kg bw), 30,000 ppm KASAL II (3761 mg Al/kg diet; ~ daily dose 288 mg Al/kg bw), 14,470 ppm Al hydroxide as a positive control (4034 mg Al/kg diet; ~ daily dose 302 mg Al/kg bw), or the basic (control) diet (66 mg Al/kg diet; ~ daily dose 5 mg Al/kg bw) (Hicks et al, 1987). Other than a significant increase of serum sodium, no significant effects were seen in bone Al, gross autopsy, histopathology, food consumption, hematology, clinical chemistry or organ weight.…”

Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese

“…A study was conducted by Stauffer Chemical Company in male rats fed their basic SALP-containing products. The treatment groups ate feed for 28 days containing: 3% KASAL (1866 mg Al/kg diet; ~ daily dose 141 mg/kg bw), 0.7% KASAL II (908 mg Al/kg diet; ~ daily dose 67 mg Al/ kg bw), 30,000 ppm KASAL II (3761 mg Al/kg diet; ~ daily dose 288 mg Al/kg bw), 14,470 ppm Al hydroxide as a positive control (4034 mg Al/kg diet; ~ daily dose 302 mg Al/kg bw), or the basic (control) diet (66 mg Al/kg diet; ~ daily dose 5 mg Al/kg bw) (Hicks et al, 1987). Other than a significant increase of serum sodium, no significant effects were seen in bone Al, gross autopsy, histopathology, food consumption, hematology, clinical chemistry or organ weight.…”

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

“…Testis weight was 168% of controls Melograna and Yokel (1984) Sprague 141, 288, or 302 (1876, 3948, 8064, or 8456) Testes calcification, degeneration with atrophy, and edema were not significantly increased above controls Hicks et al (1987) Human sperm Exposed for 0, 10, 30, or 60 min to bovine estrous cervical mucus that had been in contact with 10, 100, or 200 lM/ml AlCl 3…”

“…Notes 1. Benett et al (1975), Dixon et al (1979), McCormack et al (1979, Katz et al (1984), Wide (1984), Cranmer et al (1986), Hicks et al (1987), Bernuzzi et al (1989), Muller et al (1990), Roy et al (1991), Misawa and Shigeta (1992), Muller et al (1993), Agarwal et al (1996), , , Gonda et al (1997), Albina et al (1999), Guo et al (2005b, 2006287), Beekhuijzen (2007), Wise et al (2008), Guo et al (2009) rabbit diet consumption of 5% of body weight daily was assumed http://agritech.tnau.ac.in/animal_husbandry/animhus_rabbit%20feeding.html, https://www.purinamills.com/rabbit-food/products/detail/ purina-fibre3-rabbit-feed. Daily water intake for guinea pigs was assumed to be 0.15 l/kg.…”

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

“…Studies involving dietary administration of Al(OH) 3 and SALP basic to groups of 25 male Sprague-Dawley rats for 28 days resulted in no effects at the highest tested doses, which were in the region of 140-300 mg Al/kg bw per day (Hicks et al, 1987).…”

Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese

“…A study was conducted by Stauffer Chemical Company in male rats fed their basic SALP-containing products. The treatment groups ate feed for 28 days containing: 3% KASAL (1866 mg Al/kg diet; ~ daily dose 141 mg/kg bw), 0.7% KASAL II (908 mg Al/kg diet; ~ daily dose 67 mg Al/ kg bw), 30,000 ppm KASAL II (3761 mg Al/kg diet; ~ daily dose 288 mg Al/kg bw), 14,470 ppm Al hydroxide as a positive control (4034 mg Al/kg diet; ~ daily dose 302 mg Al/kg bw), or the basic (control) diet (66 mg Al/kg diet; ~ daily dose 5 mg Al/kg bw) (Hicks et al, 1987). Other than a significant increase of serum sodium, no significant effects were seen in bone Al, gross autopsy, histopathology, food consumption, hematology, clinical chemistry or organ weight.…”

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

“…Testis weight was 168% of controls Melograna and Yokel (1984) Sprague 141, 288, or 302 (1876, 3948, 8064, or 8456) Testes calcification, degeneration with atrophy, and edema were not significantly increased above controls Hicks et al (1987) Human sperm Exposed for 0, 10, 30, or 60 min to bovine estrous cervical mucus that had been in contact with 10, 100, or 200 lM/ml AlCl 3…”

“…Notes 1. Benett et al (1975), Dixon et al (1979), McCormack et al (1979, Katz et al (1984), Wide (1984), Cranmer et al (1986), Hicks et al (1987), Bernuzzi et al (1989), Muller et al (1990), Roy et al (1991), Misawa and Shigeta (1992), Muller et al (1993), Agarwal et al (1996), , , Gonda et al (1997), Albina et al (1999), Guo et al (2005b, 2006287), Beekhuijzen (2007), Wise et al (2008), Guo et al (2009) rabbit diet consumption of 5% of body weight daily was assumed http://agritech.tnau.ac.in/animal_husbandry/animhus_rabbit%20feeding.html, https://www.purinamills.com/rabbit-food/products/detail/ purina-fibre3-rabbit-feed. Daily water intake for guinea pigs was assumed to be 0.15 l/kg.…”

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

“…Studies involving dietary administration of Al(OH) 3 and SALP basic to groups of 25 male Sprague-Dawley rats for 28 days resulted in no effects at the highest tested doses, which were in the region of 140-300 mg Al/kg bw per day (Hicks et al, 1987).…”

Aluminum bioavailability from basic sodium aluminum phosphate, an approved food additive emulsifying agent, incorporated in cheese

“…A study was conducted by Stauffer Chemical Company in male rats fed their basic SALP-containing products. The treatment groups ate feed for 28 days containing: 3% KASAL (1866 mg Al/kg diet; ~ daily dose 141 mg/kg bw), 0.7% KASAL II (908 mg Al/kg diet; ~ daily dose 67 mg Al/ kg bw), 30,000 ppm KASAL II (3761 mg Al/kg diet; ~ daily dose 288 mg Al/kg bw), 14,470 ppm Al hydroxide as a positive control (4034 mg Al/kg diet; ~ daily dose 302 mg Al/kg bw), or the basic (control) diet (66 mg Al/kg diet; ~ daily dose 5 mg Al/kg bw) (Hicks et al, 1987). Other than a significant increase of serum sodium, no significant effects were seen in bone Al, gross autopsy, histopathology, food consumption, hematology, clinical chemistry or organ weight.…”

Aluminum reproductive toxicity: a summary and interpretation of scientific reports

“…Testis weight was 168% of controls Melograna and Yokel (1984) Sprague 141, 288, or 302 (1876, 3948, 8064, or 8456) Testes calcification, degeneration with atrophy, and edema were not significantly increased above controls Hicks et al (1987) Human sperm Exposed for 0, 10, 30, or 60 min to bovine estrous cervical mucus that had been in contact with 10, 100, or 200 lM/ml AlCl 3…”

“…Notes 1. Benett et al (1975), Dixon et al (1979), McCormack et al (1979, Katz et al (1984), Wide (1984), Cranmer et al (1986), Hicks et al (1987), Bernuzzi et al (1989), Muller et al (1990), Roy et al (1991), Misawa and Shigeta (1992), Muller et al (1993), Agarwal et al (1996), , , Gonda et al (1997), Albina et al (1999), Guo et al (2005b, 2006287), Beekhuijzen (2007), Wise et al (2008), Guo et al (2009) rabbit diet consumption of 5% of body weight daily was assumed http://agritech.tnau.ac.in/animal_husbandry/animhus_rabbit%20feeding.html, https://www.purinamills.com/rabbit-food/products/detail/ purina-fibre3-rabbit-feed. Daily water intake for guinea pigs was assumed to be 0.15 l/kg.…”

Safety of aluminium from dietary intake ‐ Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Food Contact Materials (AFC)

“…Studies involving dietary administration of Al(OH) 3 and SALP basic to groups of 25 male Sprague-Dawley rats for 28 days resulted in no effects at the highest tested doses, which were in the region of 140-300 mg Al/kg bw per day (Hicks et al, 1987).…”