Toxic erythema with generalized follicular pustules caused by streptomycin

Acute Generalized Exanthematous Pustulosis Induced by Dexamethasone Injection

“…and so on. Since Beylot et al [9] reported 4 cases of two unique generalized pustulosis and first used the term 'pustuloses exanthématiques aigues généra lisées' as a new clinical entity, similar cases have been reported under the term of AGEP [3,10]. Most drugs responsible for AGEP are antibiotics.…”

Acute generalized exanthematous pustulosis due to thallium

“…In an analysis of 63 cases a responsible drug was found in 87% of the patients with this dermatosis and betalactam antibiotics were implicated as the causative agents in 80% of these patients. 1 The long list of responsible agents include macrolide antibiotics, 1 cephalosporins, 7 doxycycline, 9 chloramphenicol succinate, 10 norfloxacin, 10 ofloxacin, 11 streptomycin sulphate, 12 isoniazid, 13,14 salazo-sulphapyridine, 13,14 pyrimethamine, 15 piperazine ethionamate, 15 furosemide, 15 nitrazepan, 15 itraconazole, 15 diltiazem, 16 captopril, 17 enalapril, 18 acetyl salicylic acid, 19 naproxen, 20 allopurinol, 21 eprazinone, 22 hydroxychloroquine 23 and chlorpromazine. 24 Adverse drug reaction may be the inevitable price paid for the benefits of some diagnostic procedures.…”

Generalized Eruptive Pustular Drug Rash due to Cephalexin

“…Drug-related generalized eruptive pustu lar rashes have previously been described in the literature with reference to streptomycin [3], phenytoin [4], piperazine [2], chloram phenicol [2], pyrimethamine [2], furosemide [2] and amoxicillin [5]: Recently, Kalb and Grossman [6] reported the case of a 74-year-old black woman who developed a diffuse pustular rash with fever within 24 h after starting cephradine, a first generation cephalosporin closely related to cephalexin [7]. The pathogenesis of drug-related acute generalized exanthematous pustulosis is still unknown and subject to speculation [1].…”