Toxic Epidermal Necrolysis From Graft-vs-Host Disease

Abstract

An infant with diarrhea, failure to thrive, and a seborrhea-like skin eruption was thought to have fatal familial Leiner's syndrome. Treatment with nonirradiated plasma was followed by graft-vs-host disease and fatal toxic epidermal necrolysis; thymic hypoplasia was found at autopsy. Accurate diagnosis of immunodeficiency syndromes is essential to avoid potentially harmful therapy.

Toxic Epidermal Necrolysis Associated with Klebsiella Pneumoniae Sepsis

“…Features of the present (8), has also been implicated (9). TEN has also been described in association with malignancy (11) and graft versus host disease (12). In early infancy, the major disease in the differential diagnosis is the staphylococcal scalded skin syndrome (SSSS).…”

Clinical, Histological, and Immunohistological Studies of Postoperative Erythroderma

“…Merot et al (11) stated that experimental data and clinical findings strongly suggest that TEN and GVHD may be mediated by similar immunologic events. McCarty et al (18) described an infant with thymic hypoplasia who presented a fatal TEN after plasma infusions and attributed to GVHD from lymphocytes in the fresh plasma. Goens et al (19) attributed to GVHD the fatal cases of TEN associated with pancytopenia.…”

A Clinical Review: Cutaneous Manifestations of Acute and Chronic Graft‐versus‐Host Disease Following Bone Marrow Transplantation

“…The distribution of the skin rash is more frequently on the upper half of the body than on the lower one. The most severe skin rash of GVHD, toxic epidermal necrolysis, has been reported (11)(12)(13). In the oral cavity, erosion, ulceration, and mucocitis may also be seen, but it is hard to distinguish oral acute GVHD from chemoradiotherapy-associated mucositis.…”