Toxic epidermal necrolysis and Stevens-Johnson syndrome. An epidemiologic study from West Germany

Clinical, Etiologic, and Histopathologic Features of Stevens-Johnson Syndrome During an 8-Year Period at Mayo Clinic

“…This finding is concordant with the emphasis in the medical literature on SJS as a disease that occurs predominantly in younger patients. 1,11 In addition to delineating SJS as a distinct entity from EM major by the clinical pattern of cutaneous lesions, For personal use. Mass reproduce only with permission from Mayo Clinic Proceedings a .…”

“…Previous studies enumerating medications specifically associated with SJS have identified antibiotics, anticonvulsants, and nonsteroidal anti-inflammatory drugs. 10,11,[13][14][15][16] A recent multinational case-control study in Europe called EuroSCAR (European Study of Severe Cutaneous Adverse Reactions) showed a high risk of SJS with the following medications: trimethoprim-sulfamethoxazole and other anti-infective sulfonamides, lamotrigine, carbamazepine, phenytoin, phenobarbital, allopurinol, nevirapine, and oxicam nonsteroidal anti-inflammatory drugs. 13 Among recently marketed drugs, nevirapine and lamotrigine were strongly associated with SJS, with sertraline showing a lower but still significant risk as well.…”

Safety and Tolerability of Antiepileptic Drug Treatment in Children with Epilepsy

“…[111,113] Bacterial infection and respiratory illness are often responsible for mortality resulting from SJS or TEN. [114,115] Aplastic anaemia is the most frequent and serious haematological reaction reported with AEDs.…”

High-dose intravenous immunoglobulin in the treatment of toxic epidermal necrolysis: a study of ocular benefits

“…The mortality from TEN in large studies ranged from 25 to 34%. 1,2 There is a paucity of literature on the prevalence, effects of immunomodulatory therapies and outcomes of ocular complications of SJS/TEN. Ocular complications may occur acutely, together with or after the onset of skin denudation.…”