Toxic Epidermal Necrolyis after Vancomycin Use

Changela, Avani; Javaiya, Hemangkumar; Rickenback, Kiersten; Elnawawi, Ashraf; Changela, Kinesh

doi:10.1097/mjt.0b013e3181f94c27

Cited by 4 publications

(1 citation statement)

References 15 publications

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“…VCM can trigger DRESS syndrome [15], Stevens-Johnson syndrome/toxic epidermal necrosis [16,17], leukocytoclastic vasculitis [18], agranulocytosis [19], or red man syndrome as adverse reactions [20]. While the mechanisms involved in VCM-induced EP are not entirely clear, VCM promotes degranulation of mast cells and basophils, resulting in the release of histamine [20].…”

Section: Discussionmentioning

confidence: 99%

Eosinophilic Pneumonia Putatively Induced by Vancomycin: A Case Report

et al. 2019

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Patient: Male, 65Final Diagnosis: Eosinophilic Pneumonia putatively induced by vancomycinSymptoms: Dyspnea • fatigue • fever • hypoxiaMedication: VancomycinClinical Procedure: Discontinuation of vancomycin and administration of prednisoloneSpecialty: General and Internal MedicineObjective:Adverse events of drug therapyBackground:Herein, we describe a case of eosinophilic pneumonia that was likely to have been induced by vancomycin.Case Report:A 65-year-old man on maintenance hemodialysis presented with chest pain and dyspnea. He subsequently developed methicillin-resistant Staphylococcus aureus-positive acute pleural empyema in an evacuated right-sided pneumothorax. Surgical thoracoscopic curettage was ultimately performed, but dyspnea recurred postoperatively. Computed tomography depicted widespread reticular shadowing of the left lung, and peripheral eosinophilia was detected. The proportion of eosinophils found in bronchoalveolar lavage fluid was also remarkable (43%). All symptoms and the results of laboratory tests immediately improved after the discontinuation of vancomycin and initiation of prednisolone therapy.Conclusions:We attribute this case of eosinophilic pneumonia to vancomycin, because all other candidate causes were ruled out, and only vancomycin fulfilled the criteria of both drug-induced eosinophilic pneumonia and drug-induced lung injury. If confirmed, this constitutes the first reported case of vancomycin-induced eosinophilic pneumonia.

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