Toxic effects of paroxetine on sexual and reproductive functions of rats

El-Gaafarawi, Inass I.; Hassan, Magdy; Fouad, Ghada; El-Komey, Fathy

doi:10.21608/ejhm.2005.18045

Cited by 19 publications

(5 citation statements)

References 2 publications

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“…In this work, UPLC-MS detected nine triterpenoids with a high content from PGE, mainly oleanolic acid saponins. After taking PRX, the gonad function of male mice decreased, mainly manifested as decreased sex hormone levels, testicular tissue structure damage, testicular marker enzyme activity, and sperm quality, which is similar to the results of EL-Gaafarawi et al [68] Saikia Q [8], and Yakubu et al [61]. However, after the PGE treatment, the sex hormone levels and testicular tissue structure of mice were effectively improved, which may be related to the oleanolic acid saponins contained in it, which is similar to the results reported in previous studies.…”

Section: Discussionsupporting

confidence: 87%

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Huang,

Wu,

Qin

2023

Foods

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Pfaffia glomerata extract (PGE) has a variety of biological activities. However, its ameliorative effect on and exact working mechanism in male sexual dysfunction are still poorly understood. This study aims to evaluate the ameliorative effect of PGE on paroxetine (PRX)-induced sexual dysfunction in male mice and uses molecular docking technology to investigate its underlying mechanism. In this work, PRX-induced sexual dysfunction was caused and PGE was gavaged in mice for 28 days. The results show that PGE significantly improved the sexual performance of mice and reduced the damage to testicular tissues. Further studies showed that PGE restored serum sex hormones to normal levels and increased nitric oxide (NO) and cyclic guanosine monophosphate (cGMP) levels as well as nitric oxide synthase (NOS) activity in penile tissues, while also decreasing phosphodiesterase-5 (PDE-5) activity, thereby maintaining normal penile erection in mice. In addition, PGE improved the activities of enzymes (LDH, ACP, and ALP) related to energy metabolism in the testis and significantly increased sperm count and viability in mice. Furthermore, the molecular docking results show that all eight compounds in PGE could form a stable complex with PDE-5 and inhibit the activity of PDE-5. In conclusion, PGE had an ameliorative effect on PRX-induced sexual dysfunction, suggesting that PGE has a potential protective effect on male sexual health.

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Section: Discussionsupporting

confidence: 87%

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Huang,

Wu,

Qin

2023

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“…Significantly increased level of PRL (hyperprolactinemia) in RES+FLX-treated mice is consistent with the finding reported in the rat [62]. Paroxetine and other SSRIs have also been reported to cause hyperprolactinemia in the rat [17,59]. Hyperprolactinemia inhibits the pulsatile release of LH, FSH, and testosterone [61] resulting in marked effects on spermatogenesis ranging from alteration in sperm quality to complete spermatogenic arrest [62,63].…”

Section: /11supporting

confidence: 85%

“…Significantly reduced level of serum estradiol found in RES+FLX-treated mice may be the contributing factor in causing suppression of spermatogenesis. Paroxetine, another SSRI, also causes spermatogenic suppression by inducing significant reduction in the level of estradiol in the depressed rat [59].…”

Section: /11mentioning

confidence: 99%

Antidepressant-Induced Testicular Alterations in the Normal and Depressed Mice

Kumar,

Tripathi,

Singh

2024

JSM Sexual Med

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“…This affirms the work of Sayed and Zidan [34], who reported significant decreased levels of LH, FSH and testosterone with increased prolactin hormone after tramadol administration in male rats. El-Gaafarawi et al [35] reported significant reduced LH, FSH and testosterone in tramadol administered male rats. In our study, codeine administration for 30 days reduced the sex hormonal activity of the male albino rats, an effect that may have emanated from loss of testicular tissues, and/or testicular injuries.…”

Section: Resultsmentioning

confidence: 98%

Ameliorative Capacity of Rice Husk Extract on Codeine-induced Testicular Dysfunction in Male Wistar Albino Rats

Nnadiukwu,

Onyeike

et al. 2023

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Rice husks (RHs) is an agro waste generated from rice production with limited application. Codeine belongs to the numerous drugs of abuse worldwide and its impact on reproductive injury has been reported. This study was designed to establish the ameliorative potential of brown rice husk extract (RHE) against reproductive damage induced by codeine misuse. Experimental rats were grouped into six groups with six rats per group: Group I received only rat chow and clean water for 30 days. Group II received only codeine 10 mg/kg body weight (b.w) of rats. Group III received only RHE 500 mg/kg b.w of rats. The 4th, 5th and 6th groups received codeine 10 mg/kg/b.w alongside 250 mg, 500 mg and 1000 mg RHE, respectively. Treatments (RHE and codeine) were administered once during the early hours between 9-10 am daily for 30 days, the animals were sacrificed, and blood and tissue samples were harvested. Male reproductive hormones such as testosterone, Follicle stimulating hormone (FSH) and luteinizing hormone (LH), and sperm quality parameters were assayed. The testis tissues were excised and examined for histopathological changes. The result revealed that high dose codeine administration significantly decreased epidermal morphology, motility, and sperm count as well as testosterone, FSH, and LH concentrations, respectively. The histopathological examination revealed distinct abnormal changes in the codeine control group when compared with the other experimental groups. RHE administration significantly improved the altered assayed parameters.

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Toxic effects of paroxetine on sexual and reproductive functions of rats

Cited by 19 publications

References 2 publications

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Extract of Pfaffia glomerata Ameliorates Paroxetine-Induced Sexual Dysfunction in Male Mice and the Characterization of Its Phytoconstituents by UPLC-MS

Antidepressant-Induced Testicular Alterations in the Normal and Depressed Mice

Ameliorative Capacity of Rice Husk Extract on Codeine-induced Testicular Dysfunction in Male Wistar Albino Rats

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