Toxic Effects of Orlistat and Green Tea Extract on Testes of Adult Albino Rats:(Comparative Study)

Elfakharany, Yara; Sabik, Laila M. E.; Metwally, Doaa; Mohamed, E Zahraa

doi:10.21608/zjfm.2021.96396.1092

Cited by 1 publication

(1 citation statement)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When using Orlistat with herbs, a significant improvement in the drug's performance was observed. In an Egyptian study by researchers Sabik et al, [19], who used the drug with green tea, there was a significant improvement in the effect of the drug on tissues because herbs contain several substances that work with different mechanisms and methods, in addition to The drug worked, and this was observed in the current study as well. Histological changes in the liver when using a high dose of drugs may be due to what is known as the negative effects of the drug on the liver (Drug-Induced Liver Injury (DILI), which means that the tissues and cells of the liver are affected by the method of using the drug (through the skin, mouth, intravenous), dose, The period of drug use, when drugs are metabolized in the liver, will change in chemical composition, causing the destruction of some cells, which stimulates oxidative stress that stimulates necrosis or breakdown of the mitochondrial wall [20].…”

Section: Obese Pregnant Group Treated With Over Doses Of Liraglutidesupporting

confidence: 73%

Evaluate the Effect of Orlistat, Liraglutide, and the Herbal Supplement on the Mothers of Experimentally Fattened White Rats

Zainab Hasan Majeed,

Ektifa Abdul Hamid Muhammad,

Muna Salah Rasheed

2024

JMGCB

View full text Add to dashboard Cite

The current study aimed to evaluate the effect of orlistat, liraglutide, and the herbal supplement on the mothers of experimentally fattened white rats. The female rats were divided into two main groups, the first fed a standard ration, in which two groups were the first pregnant and the second non-pregnant, while the second main group was fed a special diet containing 35%. Fat for the purpose of fattening as a first stage and for a period of 6 weeks, then the second stage began, which is the pregnancy and treatment stage and included eight secondary groups. The first group was not treated with any drug, the second group was orlistat at a therapeutic dose, the third group was liraglutide at a therapeutic dose, the fourth group was an herbal supplement, and the fifth group was a supplement with a therapeutic dose. Of Orlistat, the sixth group is supplemented with a therapeutic dose of liraglutide, the seventh group is a high dose of orlistat, and the eighth group is a high dose of liraglutide. The current study showed that the obesity leads to changes in lipid profiles compared to control groups, as the effect of fattening is represented by an increase in the concentration of total cholesterol, triglycerides, low-density lipoproteins, very low-density lipoproteins, and a decrease in high-density lipoproteins, histological examinations. Pathological changes appeared in each of the liver tissues, represented by a large proliferation of fat droplets, steatosis, Müller bodies, collapse of the central vein wall, and lymphocytic infiltration. The two best groups were when the herbal supplement was used with both drugs, and the herbal supplement had a synergistic role. With the two drugs, it reduces the accumulation of fat in the cells.

show abstract

Section: Obese Pregnant Group Treated With Over Doses Of Liraglutidesupporting

confidence: 73%

Evaluate the Effect of Orlistat, Liraglutide, and the Herbal Supplement on the Mothers of Experimentally Fattened White Rats

Zainab Hasan Majeed,

Ektifa Abdul Hamid Muhammad,

Muna Salah Rasheed

2024

JMGCB

View full text Add to dashboard Cite

show abstract

Toxic Effects of Orlistat and Green Tea Extract on Testes of Adult Albino Rats:(Comparative Study)

Abstract: Toxic effects of……...

Cited by 1 publication

References 32 publications

Evaluate the Effect of Orlistat, Liraglutide, and the Herbal Supplement on the Mothers of Experimentally Fattened White Rats

Evaluate the Effect of Orlistat, Liraglutide, and the Herbal Supplement on the Mothers of Experimentally Fattened White Rats

Contact Info

Product

Resources

About