Toxic effects of atrazine on immune function in BALB/c mice

Chang, Jiongjiong; Liang, Chunlai; Wang, Wei; Lyu, Yong; Mao, Weifeng; Yang, Hui; Jia, Xudong; Liu, Zhaoping; Song, Yan

doi:10.1007/s11356-021-13360-4

Environ Sci Pollut Res

2021

DOI: 10.1007/s11356-021-13360-4

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Toxic effects of atrazine on immune function in BALB/c mice

Jiongjiong Chang

Chunlai Liang

Wei Wang

et al.

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Cited by 9 publications

References 38 publications

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Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Maddalon,

Cari,

Iulini

et al. 2023

Arch Toxicol

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Humans can be exposed to endocrine disruptors (EDs) in numerous ways. EDs can interfere with endogenous hormones at different levels, resulting in numerous adverse human health outcomes, including immunotoxicity. In this regard, this study aimed to investigate in vitro the possible effects of EDs on immune cells and possible gender differences. Peripheral blood mononuclear cells from healthy humans, both males and females, were exposed to 6 different EDs, namely atrazine (herbicide), cypermethrin (insecticide), diethyl phthalate (plasticizer), 17α-ethynylestradiol (contraceptive drug), perfluorooctanesulfonic acid (persistent organic pollutant), and vinclozolin (fungicide). We evaluated the effect of EDs on RACK1 (receptor for activated C kinase 1) expression, considering it as a bridge between the endocrine and the immune system, and putatively used as screening tool of immunotoxic effects of EDs. The exposure to EDs resulted at different extent in alteration in RACK1 expression, pro-inflammatory activity, natural killer lytic ability, and lymphocyte differentiation, with sex-related differences. In particular, diethyl phthalate and perfluorooctanesulfonic acid resulted the most active EDs tested, with gender differences in terms of effects and magnitude. The results from our study evidenced the ability of EDs to directly affect immune cells.

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Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Maddalon,

Cari,

Iulini

et al. 2023

Arch Toxicol

View full text Add to dashboard Cite

show abstract

Atrazine promotes breast cancer development by suppressing immune function and upregulating MMP expression

Wang

Chen

Zhao

et al. 2023

Ecotoxicology and Environmental Safety

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Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function

Gao¹,

Yang²,

Lei³

et al. 2022

Fish & Shellfish Immunology

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Toxic effects of atrazine on immune function in BALB/c mice

Cited by 9 publications

References 38 publications

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender

Atrazine promotes breast cancer development by suppressing immune function and upregulating MMP expression

Tannic acid antagonizes atrazine exposure-induced autophagy and DNA damage crosstalk in grass carp hepatocytes via NO/iNOS/NF-κB signaling pathway to maintain stable immune function

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