Toxic Effect of Cadmium, Lead, and Arsenic on the Sertoli Cell: Mechanisms of Damage Involved

Ramos-Treviño, Juan; Bassol-Mayagoitia, Susana; Hernández‐Ibarra, José Anselmo; Ruíz-Flores, Pablo; Nava-Hernández, Martha P.

doi:10.1089/dna.2017.4081

Cited by 46 publications

(26 citation statements)

References 80 publications

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“…A study has shown that synergism between lead, cadmium, and mercury can cause damage to kidney function [42]. Lead also targets testicular Sertoli cells, which may affect sperm production [43]. Lead toxicity in a children's nervous system will cause typical neurological symptoms [44].…”

Section: Discussionmentioning

confidence: 99%

Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels With Overdosed Dietary Zinc

Chen

Song

et al. 2021

Preprint

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Background: Serum prostate-specific antigen (PSA) is a primary metric for diagnosis and prognosis of prostate cancer (PCa). Exposure to heavy metals, such as lead, cadmium, mercury, and zinc can impact PSA levels in PCa patients. However, it is unclear whether this effect also occurs in men without PCa, which may lead to the overdiagnosis of PCa.Method: Data on a total of 5,089 American men who had never been diagnosed with PCa were obtained from the National Health and Nutrition Examination Survey performed from 2003–2010. The relationship between serum PSA levels (dependent variable) and concentrations of lead (μmol/L), cadmium (nmol/L), and mercury (μmol/L) were investigated with dietary zinc intake being used as a potential modifier or covariate in a weighted linear regression model and a generalized additive model. A series of bootstrapping analyses were performed to evaluate sensitivity and specificity using these models. Results: Regression analyses suggested that, in general, lead, cadmium, or mercury did not show an association with PSA levels, which was consistent with the results of the bootstrapping analyses. However, in a subgroup of participants with a high level of dietary zinc intake (≥14.12 mg/day), a significant positive association between cadmium and serum PSA was identified (1.06, 95% CI, P=0.0268, P for interaction=0.0249).Conclusions: With high-level zinc intake, serum PSA levels may rise in PCa-free men as the exposure to cadmium increases, leading to a potential risk of an overdiagnosis of PCa and unnecessary treatment. Therefore, environmental variables should be factored in the current diagnostic model for PCa that is solely based on PSA measurements. Different criteria for PSA screening are necessary based on geographical variables. Further investigations are needed to uncover the biological and biochemical relationship between zinc, cadmium, and serum PSA levels to more precisely diagnose PCa.

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Section: Discussionmentioning

confidence: 99%

Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels With Overdosed Dietary Zinc

Chen

Song

et al. 2021

Preprint

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“…Furthermore, Cd 2+ is potentially carcinogenic and teratogenic, causing several abnormalities [24,25]. Cd 2+ also contributes to the genotoxicity of other agents that may cause damage to the DNA structure [25,26].…”

Section: Discussionmentioning

confidence: 99%

CdCl2 has zero-order kinetic cellular influx and induces cytotoxicity and genotoxicity at low concentrations in human leukocytes in vitro

Santos

Serpa

Silva

et al. 2019

Rev. Colomb. Cienc. Quím. Farm.

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Cadmium (Cd2+) is a nonessential heavy metal that possesses a high capacity of bioaccumulation and exhibits toxic characteristics even at low concentrations. This study evaluated the genotoxicity and cytotoxicity in human leukocytes in vitro after exposure to a lower range of Cd2+concentration (1-25 μg/mL) using an unprecedented strategy by correlating between intracellular Cd2+ levels after exposure and cellular damage. Results demonstrated that Cd2+exposure from 5 to 25 μg/mL significantly increased the unviability of leukocytes, as well as the DNA damage, which was dose-dependent. The intracellular Cd2+ levels in leukocytes ranged from 9.85 to 94.38 pg/cell, and cytotoxicity and genotoxicity were induced at a concentration of 24.22 pg/cell. The relationship between exposure concentration and intracellular Cd2+ levels suggests that its influx occurs in human leukocytes under zeroorder kinetics.

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“…In the era of industrialization, owing to the bioaccumulation potential, harmful effects, pervasiveness, and persistence in the environment; heavy metals‐induced toxicity have become one of the main health concerns. [ 8,9 ]…”

Section: Introductionmentioning

confidence: 99%

Effects of heavy metals on reproduction owing to infertility

Bhardwaj

Paliwal

Saraf

2021

J Biochem & Molecular Tox

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The reproductive performance of most of the species is adversely affected by hazardous heavy metals like lead, cadmium, mercury, arsenic, zinc, and copper. Heavy metals are liberated in the environment by natural sources like rock weathering, volcanic eruption, and other human activities like industrial discharge, mineral mining, automobile exhaust, and so forth. Heavy metals alter several reproductive functions in both males and females like a decrease in sperm count, motility, viability, spermatogenesis, hormonal imbalance, follicular atresia, and delay in oocyte maturation, and so forth, and thus, forms an important aspect of reproductive toxicology. The present review compiles toxicity aspects of various heavy metals and their efficacy and mechanism of action in mammals.

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Toxic Effect of Cadmium, Lead, and Arsenic on the Sertoli Cell: Mechanisms of Damage Involved

Cited by 46 publications

References 80 publications

Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels With Overdosed Dietary Zinc

Exposure to Heavy Metal Elements May Significantly Increase Serum Prostate-Specific Antigen Levels With Overdosed Dietary Zinc

CdCl2 has zero-order kinetic cellular influx and induces cytotoxicity and genotoxicity at low concentrations in human leukocytes in vitro

Effects of heavy metals on reproduction owing to infertility

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