Towards the nano‐control of periodontal inflammation?

Brun, Adrian; Moignot, Nicolas; Colombier, Marie‐Laure; Dursun, Elisabeth

doi:10.1111/odi.13219

Cited by 5 publications

(2 citation statements)

References 25 publications

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“…Mechanical debridement is time-consuming, expensive, and has limited therapeutic effects in sites that are difficult to reach instrumentally, such as root furcation, root concavities, and deep periodontal pockets. Additionally, systemic antimicrobial therapy not only has insufficient effective concentration in the lesion area, but it also increases the risk of microbial resistance [ 7 , 8 ]. At present, a variety of tissue engineering materials used in the treatment of periodontitis have attracted strong attention from researchers, including scaffolds [ 9 , 10 ], hydrogels [ 11 , 12 ], and nanoparticle drug delivery systems [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

Chen

Dai

Tian

et al. 2023

Materials Today Bio

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Section: Introductionmentioning

confidence: 99%

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

Chen

Dai

Tian

et al. 2023

Materials Today Bio

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“…Various nanoparticulate systems have been investigated for the treatment of periodontitis [20,21]. Despite the large number of studies, there is no comprehensive and updated systematic review reporting the available evidence and/or indications for future research.…”

Section: Introductionmentioning

confidence: 99%

Emerging Nanotechnology in Non-Surgical Periodontal Therapy in Animal Models: A Systematic Review

et al. 2020

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Periodontitis is one of the most prevalent inflammatory diseases. Its treatment, mostly mechanical and non-surgical, shows limitations. The aim of this systematic review was to investigate the effect of nanoparticles as a treatment alone in non-surgical periodontal therapy in animal models. A systematic search was conducted in Medline/PubMed, Web of Science, The Cochrane Library and Science Direct. The eligibility criteria were: studies (i) using nanoparticles as chemotherapeutic agent or as delivery system; (ii) including preclinical controlled animal model (experimental periodontitis); (iii) reporting alveolar bone loss; (iv) written in English; and (v) published up to June 2019. Risk of bias was evaluated according to the SYstematic Review Centre for Laboratory Animal Experimentation. On the 1324 eligible studies, 11 were included. All reported advantages in using nanoparticles for the treatment of periodontitis, highlighted by a reduction in bone loss. Agents modulating inflammation seem to be more relevant than antibiotics, in terms of efficiency and risk of antibiotic resistance. In addition, poly(lactic-co-glycolic acid) or drugs used as their own carrier appear to be the most interesting nanoparticles in terms of biocompatibility. Risk of bias assessment highlighted many criteria scored as unclear. There are encouraging preclinical data of using nanoparticles as a contribution to the treatment of periodontitis.

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Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization

Bai

Lü

et al. 2021

Nano Res.

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Towards the nano‐control of periodontal inflammation?

Cited by 5 publications

References 25 publications

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

An injectable MB/BG@LG sustained release lipid gel with antibacterial and osteogenic properties for efficient treatment of chronic periodontitis in rats

Emerging Nanotechnology in Non-Surgical Periodontal Therapy in Animal Models: A Systematic Review

Polydopamine functionalized mesoporous silica as ROS-sensitive drug delivery vehicles for periodontitis treatment by modulating macrophage polarization

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