Towards optimal filtering of "standard" multifocal electroretinogram (mfERG) recordings: findings in normal and diabetic subjects

Han, Ying; Bearse, Marcus A.; Schneck, Marilyn E.; Barez, Shirin; Jacobsen, Carl H.; Adams, Anthony J.

doi:10.1136/bjo.2003.026625

Cited by 32 publications

(30 citation statements)

References 25 publications

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“…[36][37][38] We believe that previous studies, which showed a significant decrease in mfERG response amplitude and an increase in mfERG response latency, may be due to the confounding effect of media opacities and the instability of fixation. 19,39,40 The different results reported by different studies may be due to different methodologies (eg stimulus luminance and band-pass 41,42 ), assumptions, 19,21 and different criteria for subject inclusion.…”

Section: Discussionmentioning

confidence: 99%

Aging and mfERG topography

Tam

Chan

Brown

et al. 2004

Eye

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Aim To study the effect of aging retina on the multifocal electroretinogram (mfERG). Methods A total of 18 young subjects (age 18-24 years) and 36 elderly subjects (aged 60-85 years) with intraocular lenses (IOLs) were recruited for this study. No subjects had significant eye diseases or media opacities. mfERG was measured in standard conditions using the VERIS system (version 4.1). There were three groups of 18 subjects: (1) 18-25 years, (2) 60-70 years, and (3) 75-85 years. mfERG responses were grouped into central, paracentral, and peripheral regions for analysis. The N1 amplitude, P1 amplitude, N1 latency, and P1 latency of the first-order responses were analysed. Results Age had no effect on P1 latency, N1 amplitude, and P1 amplitude; however, N1 latencies from central to peripheral regions were significantly longer for group 3 than for group 1. Conclusions This study suggests that measured age-related decreases in mfERG responses are due to optical factors (decrease in retinal light levels, scatter) before the age of 70 years, but neural factors significantly affect mfERG topography after the age of 70 years.

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Section: Discussionmentioning

confidence: 99%

Aging and mfERG topography

Tam

Chan

Brown

et al. 2004

Eye

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“…Han et al also proposed using the amplification filter cutoffs of 10--100 Hz instead of 10--300 Hz to improve the signal-to-noise ratio and to lower the inter-subject variability. 82 It was shown that recordings using the lower high frequency cut-off of 100Hz enabled identification of more implicit time abnormalities in diabetic patients without retinopathy.…”

Section: Diabetic Retinopathymentioning

confidence: 99%

“…mfERG has been used in a number of studies to evaluate the retinal function in diabetic patients and most studies have demonstrated that implicit time measures are more sensitive compared with amplitude changes in detecting retinal dysfunction. 66,79,81,82,230,301,327 Palmowski et al assessed the retinal function in diabetic patients with or without diabetic retinopathy by analyzing both the first-and second-order mfERG responses. 230 Patients with diabetic retinopathy had significantly lower response amplitudes and longer implicit times for both the first-and second-order components compared with control.…”

Section: Diabetic Retinopathymentioning

confidence: 99%

The Clinical Applications of Multifocal Electroretinography: A Systematic Review

Lai

Chan

Lai

et al. 2007

Survey of Ophthalmology

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Abstract. Multifocal electroretinography (mfERG) is an investigation that can simultaneously measure multiple electroretinographic responses at different retinal locations by cross-correlation techniques. mfERG therefore allows topographic mapping of retinal function in the central 40--50 of the retina. The strength of mfERG lies in its ability to provide objective assessment of the central retinal function at different retinal areas within a short duration of time. Since the introduction of mfERG in 1992, mfERG has been applied in a large variety of clinical settings. This article reviews the clinical applications of mfERG based on the currently available evidence. mfERG has been found to be useful in the assessment of localized retinal dysfunction caused by various acquired or hereditary retinal disorders. The use of mfERG also enabled clinicians to objectively monitor the treatment outcomes as the changes in visual functions might not be reflected by subjective methods of assessment. By changing the stimulus, recording, and analysis parameters, investigation of specific retinal electrophysiological components can be performed topographically. Further developments and consolidations of these parameters will likely broaden the use of mfERG in the clinical setting.

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“…[12][13][14][15][16][17] Multifocal electroretinography (mfERG) implicit time (IT) delays are locally predictive of future nonproliferative retinopathy. [18][19][20][21][22] Optical coherence tomography (OCT) is a sensitive and reliable technique that enables us to acquire high-resolution, in vivo images of the central retina.…”

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confidence: 99%