2018
DOI: 10.1016/j.arr.2018.07.004
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Abstract: Biomarker panels for frailty would be of high value and better than single markers. Based on our search we would propose a core panel of frailty biomarkers consisting of (1) CXCL10 (C-X-C motif chemokine ligand 10), IL-6 (interleukin 6), CX3CL1 (C-X3-C motif chemokine ligand 1), (2) GDF15 (growth differentiation factor 15), FNDC5 (fibronectin type III domain containing 5), vimentin (VIM), (3) regucalcin (RGN/SMP30), calreticulin, (4) PLAU (plasminogen activator, urokinase), AGT (angiotensinogen), (5) BDNF (bra… Show more

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Cited by 314 publications
(228 citation statements)
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“…Of note, calreticulin is used by macrophages to tag cells to be removed by programmed cell phagocytosis 66 . Consistent with this finding, CALR is considered a main biomarker of age-related diseases and frailty 67 .…”
Section: Differential Regulation Of Proteins Related To Proteostasissupporting
confidence: 59%
“…Of note, calreticulin is used by macrophages to tag cells to be removed by programmed cell phagocytosis 66 . Consistent with this finding, CALR is considered a main biomarker of age-related diseases and frailty 67 .…”
Section: Differential Regulation Of Proteins Related To Proteostasissupporting
confidence: 59%
“…The various SASP components, such as inflammatory molecules (cytokines and chemokines, extracellular damage‐associated alarmin high‐mobility group box 1 [HMGB1] protein), growth factors and regulators (transforming growth factor beta [TGFβ], insulin‐like growth factor‐binding proteins [IGFBPs]), extracellular proteinases and their inhibitors (matrix metalloproteinases [MMPs], tissue inhibitors of metalloproteinases [TIMPs], plasminogen activator inhibitor‐1 [PAI‐1]) are among candidate biomarkers of aging. [ 37,47 ] Monitoring SASP factors can constitute a promising and feasible approach for the evaluation of general tissue or cell culture senescence status [ 48 ] ; however, the profile of secreted proteins may vary significantly depending on cell type and stage of senescence, [ 37,49 ] complicating the determination of optimal threshold values for all types of cells.…”
Section: Molecular and Cellular Biomarkersmentioning
confidence: 99%
“…The latter might explain the lack of uniformity between the respondents using these type of tests in their preoperative physical fitness assessment. Moreover, besides measuring cardiorespiratory fitness, it is important to preoperatively assess muscle strength and functional mobility, as these components of physical fitness are a prerequisite for (early) mobilization and being physically active postoperatively [42].…”
Section: Discussionmentioning
confidence: 99%
“…Besides the pathophysiology of cancer cachexia, disease symptoms and anti-tumor therapies (e.g., chemo-, radio-, immunotherapy) hamper adequate food-intake (e.g., vomiting, nausea, early satiety). This influences the clinical course of the disease, the patient's physical performance, and the patient's quality of life, especially in frail elderly [39,40,42]. Frailty can be defined as a diminished adaptive capacity and increased vulnerability to cope with events (e.g., surgery, chemoradiation, hospitalization), that are stressors for the physiological system [38,43].…”
Section: Preoperative Stressorsmentioning
confidence: 99%
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