Towards developing effective hyperthermia treatment for tumours in the nasopharyngeal region

Paulides, Margarethus M.; Rhoon, Gerard C. van

doi:10.3109/02656736.2011.564599

Cited by 6 publications

(7 citation statements)

References 24 publications

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“…The study of Hua et al used nasopharyngeal cavity hyperthermia added to irradiation and chemotherapy for nasopharyngeal cancer. They showed improved 5 year local control for the hyperthermia group (91% versus 79%) [32,34]. Huilgol et al showed improved complete response (79% versus 42%) and increased median survival time (241 vs 145 days) for the patients treated with irradiation combined with hyperthermia, compared to irradiation alone [15].…”

Section: Discussionmentioning

confidence: 99%

Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma – a feasibility study

Verduijn

Wee

Rijnen

et al. 2018

International Journal of Hyperthermia

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Section: Discussionmentioning

confidence: 99%

Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma – a feasibility study

Verduijn

Wee

Rijnen

et al. 2018

International Journal of Hyperthermia

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“…Heating and QA: Specifically designed intracavitary equipment was used based on a commercially available device (WE2102-A Microwave HT System, Yuan De Biomedical Engineering, Beijing). The technique employed was mentioned to be 915 MHz microwave radiation [ 25 ], but the reply to a letter to the editor [ 15 ] mentions a hot wire based conductive heating technique [ 26 ]. Patient specific quality assurance was performed in this study by measuring the temperature of the nasal cavity mucosa using a thermocouple temperature sensor.…”

Section: Reviewmentioning

confidence: 99%

“…In addition, the technologies and strategies applied provide limited control of the applied thermal dose. This makes it difficult to reproduce the results or to quantify the level of temperature rise or thermal dose required [ 15 ]. Hence, although these trials demonstrated statistically significant outcomes, the clinical objective in terms of required temperature or thermal dose cannot be quantified.…”

Section: Introductionmentioning

confidence: 99%

Status quo and directions in deep head and neck hyperthermia

2016

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The benefit of hyperthermia as a potent modifier of radiotherapy has been well established and more recently also the combination with chemotherapy was shown beneficial. Also for head and neck cancer, the impact of hyperthermia has been clinically demonstrated by a number of clinical trials. Unfortunately, the technology applied in these studies provided only limited thermal dose control, and the devices used only allowed treatment of target regions close to the skin. Over the last decade, we developed the technology for deep and controlled hyperthermia that allows treatment of the entire head and neck region. Our strategy involves focused microwave heating combined with 3D patient-specific electromagnetic and thermal simulations for conformal, reproducible and adaptive hyperthermia application. Validation of our strategy has been performed by 3D thermal dose assessment based on invasively placed temperature sensors combined with the 3D patient specific simulations. In this paper, we review the phase III clinical evidence for hyperthermia in head and neck tumors, as well as the heating and dosimetry technology applied in these studies. Next, we describe the development, clinical implementation and validation of 3D guided deep hyperthermia with the HYPERcollar, and its second generation, i.e. the HYPERcollar3D. Lastly, we discuss early clinical results and provide an outlook for this technology.

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“…Recently, Huilgol et al proved an enhancement of RT [5] and promising results for chemoradiation [6] by capacitive HT. Using intracavitary equipment based on a resistive wire, Hua et al also showed the benefit of adding HT to RT for nasopharynx tumours [7,8].…”

Section: Introductionmentioning

confidence: 99%

Quality and comfort in head and neck hyperthermia: A redesign according to clinical experience and simulation studies

Rijnen

Togni

Roskam

et al. 2015

International Journal of Hyperthermia

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The HYPERcollar redesign improves water bolus shape, stability and skin contact. The renewed positioning strategy allows for positioning of the patient within the required precision of ±5 mm. By clinically introducing the new design, we aim at improving not only treatment quality and reproducibility, but also patient comfort and operator handling, which are all important for a better hyperthermia treatment quality.

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Towards developing effective hyperthermia treatment for tumours in the nasopharyngeal region

Cited by 6 publications

References 24 publications

Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma – a feasibility study

Deep hyperthermia with the HYPERcollar system combined with irradiation for advanced head and neck carcinoma – a feasibility study

Status quo and directions in deep head and neck hyperthermia

Quality and comfort in head and neck hyperthermia: A redesign according to clinical experience and simulation studies

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