Towards absolute calibration of optical tweezers

Viana, Nathan B.; Rocha, M. S.; Mesquita, O. N.; Mazolli, A.; Neto, Paulo A. Maia; Nussenzveig, H. M.

doi:10.1103/physreve.75.021914

Cited by 98 publications

(84 citation statements)

References 32 publications

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“…In addition annular beams show improved axial localization and an increase in axial:lateral trap stiffness ratio. These improvements show excellent agreement with theoretical models of these systems [2], using a modification of Mie-Debye spherical aberration theory [3,4].…”

Section: Optical Trapping Using An Annular Beamsupporting

confidence: 57%

Axial Localization Improvements when Trapping Aerosol Droplets using an Annular Beam

Dear

Burnham

Summers

et al. 2013

Optics in the Life Sciences

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Abstract:We demonstrate that annular beam traps lead to an increased size range and improved axial trapping of aerosols in comparison to Gaussian beam traps. These methods are extended to consider ionic liquid samples. Optical trapping using an annular beamIn this work we quantify the improvements that can be achieved by using an annular beam trap, formed by blocking the centre of a Gaussian beam [1]. These improvements include an increase in the range of trappable particles, both in terms of the refractive index contrast between the trapping medium and particle, with particular applications in aerosol trapping where this contrast is large, and also an increase in the size range of trappable salt water aerosol droplets. In addition annular beams show improved axial localization and an increase in axial:lateral trap stiffness ratio. These improvements show excellent agreement with theoretical models of these systems [2], using a modification of Mie-Debye spherical aberration theory [3,4]. Micro-viscosity measurements in ionic liquidsUsing a combination of high-speed camera tracking and back focal plane interferometry we have extended this work to include an investigation into the trapping of both ionic liquid droplets, defined as organic salts with a melting point below 100 C, and of tracer particles in ionic liquid samples. These methods have allowed us to monitor micro-viscosity changes under a variety of different conditions in these novel media.

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Section: Optical Trapping Using An Annular Beamsupporting

confidence: 57%

Axial Localization Improvements when Trapping Aerosol Droplets using an Annular Beam

Dear

Burnham

Summers

et al. 2013

Optics in the Life Sciences

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“…The scattered field can be expressed analytically only for a limited number of symmetries of the object. The most frequently treated shape is a sphere where Mie scattering theory is used ͑Barton et al, 1989;Ren et al, 1996;Mazolli et al, 2003;Rohrbach, 2005;Neves et al, 2007;Viana et al, 2007͒. A group of spheres can be treated using the multiple Mie scattering theory ͑Xu, 1995; .…”

Section: Optical Forcesmentioning

confidence: 99%

Colloquium: Gripped by light: Optical binding

2010

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͑Published 3 June 2010͒The light-matter interaction has been at the heart of major advances from the atomic scale right to the microscopic scale over the past four decades. Confinement by light, embodied by the area of optical trapping, has had a major influence across all of the natural sciences. However, an emergent and powerful topic within this field that has steadily merged but not gained much recognition is optical binding: the importance of exploring the optically mediated interaction between assembled objects that can cause attractive and repulsive forces and dramatically influence the way they assemble and organize themselves. This offers routes for colloidal self-assembly, crystallization, and organization of templates for biological and colloidal sciences. In this Colloquium, this emergent area is reviewed looking at the pioneering experiments in the field and the various theoretical approaches that aim to describe this behavior. The latest experimental studies in the field are reviewed and theoretical approaches are now beginning to converge to describe the binding behavior seen. Recent links between optical binding and nonlinearity are explored as well as future themes and challenges.

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“…This unique feature is highly desirable for cell manipulation in sterile conditions. OT have been applied to relocate neuron cells to form cell groups (Townes-Anderson et al 1998). Some of the neuron cells were cultured on the adherent side of a culture dish and others on the less adhesive side.…”

Section: Active Nanomanipulationmentioning

confidence: 99%

“…Theoretical approaches have been developed for absolute and precise calibration for a single beam (Hansen et al 2006;Viana et al 2007) and those models will be extended for multiple traps. Experimental methods using a QDP to detect the nanometre resolution displacement of beads have been used to characterize and calibrate multiple traps (Guilford et al 2004;Dharmadhikari et al 2007).…”

Section: Multiple Trapsmentioning

confidence: 99%

Optical tweezers for single cells

Zhang

Liu

2008

J. R. Soc. Interface.

646

415

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Optical tweezers (OT) have emerged as an essential tool for manipulating single biological cells and performing sophisticated biophysical/biomechanical characterizations. Distinct advantages of using tweezers for these characterizations include non-contact force for cell manipulation, force resolution as accurate as 100 aN and amiability to liquid medium environments. Their wide range of applications, such as transporting foreign materials into single cells, delivering cells to specific locations and sorting cells in microfluidic systems, are reviewed in this article. Recent developments of OT for nanomechanical characterization of various biological cells are discussed in terms of both their theoretical and experimental advancements. The future trends of employing OT in single cells, especially in stem cell delivery, tissue engineering and regenerative medicine, are prospected. More importantly, current limitations and future challenges of OT for these new paradigms are also highlighted in this review.

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Towards absolute calibration of optical tweezers

Cited by 98 publications

References 32 publications

Axial Localization Improvements when Trapping Aerosol Droplets using an Annular Beam

Axial Localization Improvements when Trapping Aerosol Droplets using an Annular Beam

Colloquium: Gripped by light: Optical binding

Optical tweezers for single cells

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