Toward improvements for carrying capacity of the cyclodextrin-based nanosponges: recent progress from a material and drug delivery

Deng, Jing; Chen, Qi Jue; Li, Wen; Zuberi, Zavuga; Feng, Jian Xiang; Lin, Qiyuan; Ren, Jia; Luo, Fei; Ding, Quan Ming; Zeng, Xiao; Ma, Liang; Yin, Hua; Zheng, Xiang Min

doi:10.1007/s10853-020-05646-8

Cited by 31 publications

(16 citation statements)

References 111 publications

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“…The inclusion complex of curcumin with cyclodextrin polymer [ 23 , 51 , 52 , 53 , 54 ] and with cyclodextrin-based nanosponges [ 55 , 56 , 57 , 58 , 59 , 60 ] was studied thoroughly in previously published research and was reported to have an effect on the enhancement of curcumin solubility, release rate, stability, and cytotoxicity [ 55 , 56 , 57 , 58 , 59 , 60 , 61 ]. However, there was no comparison between nanosponges and direct β-cyclodextrin complexations for curcumin.…”

Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

2021

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Cyclodextrin polymers and cyclodextrin-based nanosponges have been widely investigated for increasing drug bioavailability. This study examined curcumin’s complexation stability and solubilization with β-cyclodextrin and β-cyclodextrin-based nanosponge. Nanosponges were prepared through the cross-linking of β-cyclodextrin with different molar ratios of diphenyl carbonate. Phase solubility experiments were conducted to evaluate the formed complexes and evaluate the potential of using β-cyclodextrin and nanosponge in pharmaceutical formulations. Furthermore, physicochemical characterizations of the prepared complexes included PXRD, FTIR, NMR, and DSC. In addition, in vitro release studies were performed for the prepared formulations. The formation of β-cyclodextrin complexes enhanced curcumin solubility up to 2.34-fold compared to the inherent solubility, compared to a 2.95-fold increment in curcumin solubility when loaded in β-cyclodextrin-based nanosponges. Interestingly, the stability constant for curcumin nanosponges was (4972.90 M−1), which was ten times higher than that for the β-cyclodextrin complex, where the value was 487.34 M−1. The study results indicated a decrease in the complexation efficiency and solubilization effect with the increased cross-linker amount. This study’s findings showed the potential of using cyclodextrin-based nanosponge and the importance of studying the effect of cross-linking density for the preparation of β-cyclodextrin-based nanosponges to be used for pharmaceutical formulations.

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Section: Introductionmentioning

confidence: 99%

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

2021

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“…A poriferous structure, namely nanosponge, is a special kind of nanosphere. The complexation property of the three-dimensional structure influences the attraction and release of the molecules ( Deng et al., 2021 ). Cyclodextrins, cyclic oligosaccharides with a hydrophilic outer surface and a hydrophobic inner cavity, are widely used to increase solubility of hydrophobic drugs in water ( Varan et al., 2017 ).…”

Section: Polymer-based Strategies In Fungal Disease Treatmentmentioning

confidence: 99%

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Guo

et al. 2023

Front. Cell. Infect. Microbiol.

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Fungal diseases have posed a great challenge to global health, but have fewer solutions compared to bacterial and viral infections. Development and application of new treatment modalities for fungi are limited by their inherent essential properties as eukaryotes. The microorganism identification and drug sensitivity analyze are limited by their proliferation rates. Moreover, there are currently no vaccines for prevention. Polymer science and related interdisciplinary technologies have revolutionized the field of fungal disease management. To date, numerous advanced polymer-based systems have been developed for management of fungal diseases, including prevention, diagnosis, treatment and monitoring. In this review, we provide an overview of current needs and advances in polymer-based strategies against fungal diseases. We high light various treatment modalities. Delivery systems of antifungal drugs, systems based on polymers’ innate antifungal activities, and photodynamic therapies each follow their own mechanisms and unique design clues. We also discuss various prevention strategies including immunization and antifungal medical devices, and further describe point-of-care testing platforms as futuristic diagnostic and monitoring tools. The broad application of polymer-based strategies for both public and personal health management is prospected and integrated systems have become a promising direction. However, there is a gap between experimental studies and clinical translation. In future, well-designed in vivo trials should be conducted to reveal the underlying mechanisms and explore the efficacy as well as biosafety of polymer-based products.

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“…The cavity of the CDs allows the inclusion of hydrophobic molecules and the more hydrophilic outer polymeric network is able to accommodate less lipophilic molecules. Furthermore, CDNSs combine high biocompatibility, biodegradability and low cytotoxicity, conferred by the cyclodextrins, with high thermal stability and insolubility that arises from the fact that they are highly crosslinked polymers ( Tejashri et al, 2013 ; Shende P. et al, 2015 ; Krabicová et al, 2020 ; Deng et al, 2021 ; Mashaqbeh et al, 2021 ). Thus, it is not surprising that this type of nanomaterials has been explored for the oral, topical and parenteral delivery of numerous drugs, in controlled drug delivery systems as, for example, for target cancer therapy ( Allahyari et al, 2022 ).…”

Section: Applicationsmentioning

confidence: 99%

Cyclodextrin-Based Nanosponges: Overview and Opportunities

et al. 2022

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Nanosponges are solid cross-linked polymeric nano-sized porous structures. This broad concept involves, among others, metal organic frameworks and hydrogels. The focus of this manuscript is on cyclodextrin-based nanosponges. Cyclodextrins are cyclic oligomers of glucose derived from starch. The combined external hydrophilicity with the internal hydrophobic surface constitute a unique “microenvironment”, that confers cyclodextrins the peculiar ability to form inclusion host‒guest complexes with many hydrophobic substances. These complexes may impart beneficial modifications of the properties of guest molecules such as solubility enhancement and stabilization of labile guests. These properties complemented with the possibility of using different crosslinkers and high polymeric surface, make these sponges highly suitable for a large range of applications. Despite that, in the last 2 decades, cyclodextrin-based nanosponges have been developed for pharmaceutical and biomedical applications, taking advantage of the nontoxicity of cyclodextrins towards humans. This paper provides a critical and timely compilation of the contributions involving cyclodextrins nanosponges for those areas, but also paves the way for other important applications, including water and soil remediation and catalysis.

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Toward improvements for carrying capacity of the cyclodextrin-based nanosponges: recent progress from a material and drug delivery

Cited by 31 publications

References 111 publications

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

Evaluation and Characterization of Curcumin-β-Cyclodextrin and Cyclodextrin-Based Nanosponge Inclusion Complexation

Progress of polymer-based strategies in fungal disease management: Designed for different roles

Cyclodextrin-Based Nanosponges: Overview and Opportunities

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