Toward a More Holistic Framework for Solvent Selection

Abstract

An interactive tool has been developed to facilitate solvent selection, allowing consideration of chemical functionality, physical properties, regulatory concerns, and safety/health/environmental (SHE) impact. Appropriate solvents can be identified prior to screening experiments, and less desirable solvents can be replaced in established processes. Once a shortlist has been identified, the data can define experimental programs or else be exported to a molecular properties prediction tool to assess suitability through, e.g., solubility and partitioning.

Tools and techniques for solvent selection: green solvent selection guides

“…The future of solvent selection will inevitably require a greater sophistication in how solvents are chosen on the basis of a sustainable supply chain, and more work is needed in the area of application specific tools and life cycle assessments [96]. To do this more data will be required, especially for new solvents regarding their physical properties and their environmental impact.…”

Integrating a Biorefinery into an Operating Kraft Mill

“…Material substitutions of petroleum-based bulk chemicals such as adhesives, solvents, and surfactants can be seen as greener alternatives where sustainable sources have reduced impacts on the environment (Smith et al 2014;Diorazio et al 2016). The Australian company Circa Group developed a process to convert wood waste and other lignocellulosic materials to levoglucosenone.…”

2‐Methyltetrahydrofuran (2‐MeTHF): A Green Solvent for Pd−NHC‐Catalyzed Amide and Ester Suzuki‐Miyaura Cross‐Coupling by N−C/O−C Cleavage

“…[14,15] Remarkably, organic solvents constitute up to 90% of the non-aqueous waste generated in pharmaceutical industry, and the major waste stream in academic laboratories. [16] Given the tremendous potential of amide bond cross-coupling technologies, it is surprising that catalytic methods using green solvents are to date unknown.…”