Total Thyroidectomy With and Without Selective Central Compartment Dissection

Shindo, Maisie L.; Stern, Anna

doi:10.1001/archoto.2010.79

Cited by 53 publications

(35 citation statements)

References 21 publications

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“…Similar to bleeding, other possible sources of postoperative morbidity include dysphonia and dysphagia due to recurrent and/or superior laryngeal nerve injury, hypocalcaemia due to parathyroid ischemia or unintended deprivation, postsurgical hemorrhage, wound infection and postoperative pain. However, the risk of perioperative mortality or major disability is extremely low (2)(3)(4)(5).…”

Section: Introductionmentioning

confidence: 99%

Harmonic versus LigaSure hemostasis technique in thyroid surgery: A meta-analysis

Upadhyaya

Meng

et al. 2016

Biomedical Reports

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Section: Introductionmentioning

confidence: 99%

Harmonic versus LigaSure hemostasis technique in thyroid surgery: A meta-analysis

Upadhyaya

Meng

et al. 2016

Biomedical Reports

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“…In all procedures, total thyroidectomy with central neck exploration was the proposed surgical procedure when there was a defined cytological diagnosis of cancer or when there was clinical or intraoperative suspicion, as suggested by the literature, in addition to being the procedure adopted in our services (11,12). Surgical treatment was indicated in 107 patients with Graves' disease, who were then subjected to total thyroidectomy because anything less than total thyroidectomy fails to correct hyperthyroidism in 30% of cases (8,13).…”

Section: Resultsmentioning

confidence: 99%

Thyroid surgery performed on an overnight basis: a 17 years of experience

Molinari

Treiguer

Gava

et al. 2015

Arch. Endocrinol. Metab.

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Objective: This study aimed to evaluate the results of thyroid surgeries with hospitalization periods shorter than 18 hours performed in a surgical endocrinology service, correlating these results with type of procedure, the definitive diagnosis and complications associated with the procedure. Subjects and methods: The procedures performed, complications associated, hospitalization period, and relationships among these variables were assessed in consecutive patients subjected to different types of thyroid surgeries from January 1997 to March 2014 by the same group of surgeons. Data were analyzed by frequency, and the associations between the hospitalization period and other variables were analyzed using the Pearson chi-square test and Fisher's exact test, using a multiple comparisons test with Bonferroni correction. Results: Among the 3,411 surgeries performed, 799 of them were malignant neoplasia, 2,505 were benign tumors and 107 were Graves' disease. The following procedures were performed: total thyroidectomy (1597 patients); total thyroidectomy with neck exploration (369 patients); lobectomy plus isthmectomy (1084 patients); total thyroidectomy complementation (145 patients); total thyroidectomy with neck dissection (84 patients); modified radical total thyroidectomy (13 patients); nodulectomy (11 patients); unresectable (9 patients); central neck dissection (48 patients); lateral neck dissection (38 patients); and others (13 patients). The following surgical complications, characteristic of the procedure: hemorrhage in 41 (1.2%) patients, hypoparathyroidism in 10 (0.3%) patients and recurrent laryngeal nerve (RLN) injury in 23 (0.7%) patients. Hospitalization shorter than 18 hours was observed in 97% of patients. Conclusion: Thyroid surgery can be safely performed in virtually all patients on an overnight basis in specialized services. Arch Endocrinol Metab.2015;59(5):

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“…However, the 2006 guidelines of the American Thyroid Association recommended consideration of prophylactic bilateral cen-tral lymph node dissection for all thyroid cancer patients [10]. Total thyroidectomy with central lymphadenectomy does not increase the incidence of main complications: hypocalcemia and vocal cord paresis [11]. Sentinel lymph node biopsy has become more and more common in thyroid surgery but it is not a standard procedure like in breast cancer or melanoma [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Lymph node metastases in papillary thyroid cancer detected by quantitative real-time polymerase chain reaction for thyroglobulin and cytokeratine-19

Kaczka¹,

Fendler²,

Borowiec³

et al. 2013

pjp

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Papillary thyroid cancer (PTC) metastases in the lymph nodes (LNs) were detected by real-time polymerase chain reaction (PCR) for TG and cytokeratin 19 (CK19), and the obtained results were compared with histopathology. 107 LNs from 34 PTC patients were divided into four blocks by a special cutting device -2 for histopathology, while the other 2 were tested by quantitative real-time PCR. Metastases were detected in 20 nodes from 10 (29.4%) patients. TG and CK19 expression levels differed vastly between nodes with and without metastatic cells. ddCt of TG in the genetic material extracted from N0 nodes was 9.97 ±4.20, while in nodes with metastases ddCt was 0.91±4.20 (p < 0.0001). Cytokeratin 19 showed similar results with expression level (ddCt) in N0 nodes of 10.96 ±2.58 vs. 7.73 ±3.63 in nodes with metastases (p < 0.0001). Evaluation of the utility of both parameters showed efficient differentiation of node involvement in the case of TG, with area under the ROC curve (AUC) equal to 0.91 (95% CI: 0.85-0.96). Cytokeratin 19 also allowed for a degree of differentiation but its diagnostic efficacy was lower (AUC 0.76, 95% CI: 0.64-0.88). The combined TG and CK19 quantitative real-time PCR could be used to select a previously missed group of patients with nodal involvement undetectable by standard histopathology.

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Total Thyroidectomy With and Without Selective Central Compartment Dissection

Cited by 53 publications

References 21 publications

Harmonic versus LigaSure hemostasis technique in thyroid surgery: A meta-analysis

Harmonic versus LigaSure hemostasis technique in thyroid surgery: A meta-analysis

Thyroid surgery performed on an overnight basis: a 17 years of experience

Lymph node metastases in papillary thyroid cancer detected by quantitative real-time polymerase chain reaction for thyroglobulin and cytokeratine-19

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