Total synthesis of synargentolide B

Ramulu, Udugu; Rajaram, Singanaboina; Dasari, Ramesh; Babu, K. Suresh

doi:10.1016/j.tetasy.2015.07.007

Cited by 11 publications

(2 citation statements)

References 32 publications

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“…Suresh Babu et al followed a different strategy for the stereoselective synthesis of synargentolide B (Scheme 24) [68]. They started their synthesis with ethyl (S)-2-hydroxypropanoate (111), which was protected to form 112.…”

Section: Synargentolide Bmentioning

confidence: 99%

Recent Advances in the Stereoselective Total Synthesis of Natural Pyranones Having Long Side Chains

et al. 2020

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Pyranone natural products have attracted great attention in recent years from chemists and biologists due to their fascinating stereoisomeric structural features and impressive bioactivities. A large number of stereoselective total syntheses of these compounds have been described in the literature. The natural pyranones with long side chains have recently received significant importance in the synthetic field. In the present article, we aim to review the modern progress of the stereoselective total syntheses of these natural pyranones containing long-chain substituents.

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Section: Synargentolide Bmentioning

confidence: 99%

Recent Advances in the Stereoselective Total Synthesis of Natural Pyranones Having Long Side Chains

et al. 2020

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“…There are a huge number of other applications of Sharpless asymmetric dihydroxylation. For example, Sharpless AD has been found to be the main step in the total synthesis of Codonopsinine, Synargenotolides, Noneneolide and many more, which are isolated from different plant extracts and play a vital role against a number of bacterial diseases, in combating the spread of tumor cells and exhibiting high efficacy against malarial infections, respectively [ 23 , 24 , 25 ]. Our review highlights the recent applications of Sharpless asymmetric dihydroxylation for the synthesis of various natural products.…”

Section: Introductionmentioning

confidence: 99%

Sharpless Asymmetric Dihydroxylation: An Impressive Gadget for the Synthesis of Natural Products: A Review

et al. 2023

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Sharpless asymmetric dihydroxylation is an important reaction in the enantioselective synthesis of chiral vicinal diols that involves the treatment of alkene with osmium tetroxide along with optically active quinine ligand. Sharpless introduced this methodology after considering the importance of enantioselectivity in the total synthesis of medicinally important compounds. Vicinal diols, produced as a result of this reaction, act as intermediates in the synthesis of different naturally occurring compounds. Hence, Sharpless asymmetric dihydroxylation plays an important role in synthetic organic chemistry due to its undeniable contribution to the synthesis of biologically active organic compounds. This review emphasizes the significance of Sharpless asymmetric dihydroxylation in the total synthesis of various natural products, published since 2020.

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