Total synthesis of (−)-scabrolide A and (−)-yonarolide

Abstract

The complete account of the total syntheses of scabrolide A and yonarolide are disclosed. This article describes an initial approach involiving a bio-inspired macrocyclization/transannular Diels–Alder cascade, which ultimately failed due...

Steglich esterification: A versatile synthetic approach toward the synthesis of natural products, their analogues/derivatives

“…The epoxide 70 was transformed to (−)-scabrolide A 71 over a few steps. In 2023, Hafeman et al provided an account of all the approaches and key advancements employed to accomplish the synthesis of scabrolide A and its related natural product, inferring this class to be a relevant and substantial research area ( Scheme 11 ) [ 46 ].

Scheme 11 Total synthesis of (−)-scabrolide A 71 .

…”