Total Oxidant Status (TOS), Total Antioxidant Status (TAS), Ferritin and Vitamin D Levels in Patients with Chronic Hepatitis C

Toprak, Gülten; Sabancılar, İlhan; Özcan, Nida; Alkan, Hüseyin

doi:10.33425/2639-9458.1086

Cited by 1 publication

(2 citation statements)

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“…Regarding the level of enzymes involved in oxidative stress, Mohamed Ahmed Khedr et al [29] monitored the serum levels of glutathione peroxidase and malondialdehyde, both being low in pediatric patients with chronic hepatitis C (CHC). Another study [30] showed high levels of oxidative stress markers and ferritin and low levels of vitamin D in adults with CHC.…”

Section: Hepatitis C Virus and Oxidative Stressmentioning

confidence: 96%

“…The next step in the cascade of biochemical changes at the cellular level is mitochondrial failure, a key point in the mechanisms that determine liver injury [27,28]. The HCV core protein is known to inhibit the mitochondrial electron transport chain and decrease intracellular and mitochondrial glutathione (GSH) levels, thereby causing oxidative stress [4,29,30]. The damage to the liver structure causes changes in blood flow, resulting in tissue hypoxia [31].…”

Section: Hepatitis C Virus and Oxidative Stressmentioning

confidence: 99%

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Insights into the Management of Chronic Hepatitis in Children—From Oxidative Stress to Antioxidant Therapy

Ioniuc,

Lupu,

Tarnita

et al. 2024

IJMS

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Recent research has generated awareness of the existence of various pathophysiological pathways that contribute to the development of chronic diseases; thus, pro-oxidative factors have been accepted as significant contributors to the emergence of a wide range of diseases, from inflammatory to malignant. Redox homeostasis is especially crucial in liver pathology, as disturbances at this level have been linked to a variety of chronic diseases. Hepatitis is an umbrella term used to describe liver inflammation, which is the foundation of this disease regardless of its cause. Chronic hepatitis produces both oxidative stress generated by hepatocyte inflammation and viral inoculation. The majority of hepatitis in children is caused by a virus, and current studies reveal that 60–80% of cases become chronic, with many young patients still at risk of advancing liver damage. This review intends to emphasize the relevance of understanding these pathological redox pathways, as well as the need to update therapeutic strategies in chronic liver pathology, considering the beneficial effects of antioxidants.

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Section: Hepatitis C Virus and Oxidative Stressmentioning

confidence: 96%