Total follicle stimulating hormone dose is negatively correlated with live births in a donor/recipient model with fresh transfer: an analysis of 8,627 cycles from the Society for Assisted Reproductive Technology Registry

Shaia, Kathryn L.; Acharya, Kelly S.; Harris, Benjamin S.; Weber, Jeremy M.; Truong, Tracy; Muasher, Suheil J.

doi:10.1016/j.fertnstert.2020.04.027

Cited by 17 publications

(11 citation statements)

References 20 publications

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“…In a recent study involving 8627 donor oocyte IVF cycles, there was a negative correlation between total FSH dose and live birth rates in fresh donor IVF cycles (Shaia et al, 2020). We found a similar correlation in our data, Peri fertilization factors, including number of oocytes, grade 1(MII) oocytes and fertilization rates have been shown to affect LBR in donor oocyte IVF cycles (Hariton et al, 2017).…”

Section: Discussionsupporting

confidence: 88%

Multivariate analysis of oocyte donor and recipient factors affecting cumulative live birth rate in oocyte donor IVF (OD-IVF) cycles

Malhotra

Gupta

Yadav

et al. 2021

JBRA Assisted Reproduction

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Objective: To study donor and recipient factors affecting cumulative live birth rate (CLBR) in oocyte donor IVF (OD-IVF) cycles.Methods: The present retrospective study was conducted at the ART center of a tertiary care referral hospital after ethical approval, and included all OD-IVF cycles done between January 2014 -October 2019. Donor parameters included age, body mass index (BMI), ovarian reserve markers, serum estradiol (E2) on trigger day, and number of total/grade 1 oocytes; recipient parameters included age and BMI. The primary outcome was CLBR resulting from one complete donor-recipient (D-R) cycle through fresh/frozen embryo transfer. Secondary outcomes included number of total and grade 1 oocytes, fertilization rate, cleavage rate and clinical pregnancy rate (CPR).Results: We analyzed 262 D-R cycles for donor characteristics and 260 cycles for CLBR. The mean age of the recipients was 35.20±4.05, and for donors it was 25.29±2.03 years. The CPR and CLBR per started cycle was 60% and 55.7%, respectively. Recipient BMI and grade 1 oocytes were found to be independent predictors of CLBR in multivariate analysis. As the number of grade 1 oocytes increased, the likelihood of live births increased by 10% (95% CI, 1.04 -1.32, p=0.008). Recipient BMI ≥25kg/m² reduced the chances of CLBR by 50% (95% CI, 0.27 -0.81, p=0.007).Conclusions: Number of grade 1 oocytes and recipient BMI significantly affect CLBR in OD-IVF cycles. Recipients with BMI ≥25kg/m² may be advised to lose weight and improve CLBR likelihood.

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Section: Discussionsupporting

confidence: 88%

Multivariate analysis of oocyte donor and recipient factors affecting cumulative live birth rate in oocyte donor IVF (OD-IVF) cycles

Malhotra

Gupta

Yadav

et al. 2021

JBRA Assisted Reproduction

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“…Interestingly, the use of lower gonadotrophin doses has been associated with higher chances of live birth, potentially by oocyte selection or reduced probability for detrimental impact on oocyte development and embryo quality (Baker et al, 2015;Gerber et al, 2020;Munch et al, 2017;Shaia et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

Individualized follitropin delta dosing reduces OHSS risk in Japanese IVF/ICSI patients: a randomized controlled trial

Ishihara

Arce

2021

Reproductive BioMedicine Online

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“…Speci cally, total Gn doses < 2,000 IU were noted with 27% higher rate of live birth compared with a Gn dose > 5,000 IU (42). Both studies showed unnecessary increase in total Gn used could decrease live birth rate (42,45). In addition, supraphysiological estradiol level after higher dose of Gn used, may increase the growth hormone-binding protein in bio-neutralizing GH and diminishing the level of insulin-like growth factor, which played a role in synergism with FSH and the follicular metabolism in stimulated cycles (46).…”

Section: Discussionmentioning

confidence: 95%

“…An idea of "less is more" was raised with the fact that for each additional 100 IU of Gn usage, the likelihood of live birth decreased by 2% (44). Similarly, a very recent report demonstrated that for every 500 IU increase in FSH dosing for COS, there was a 3% decrease both in clinical pregnancy and live birth (45). Speci cally, total Gn doses < 2,000 IU were noted with 27% higher rate of live birth compared with a Gn dose > 5,000 IU (42).…”

Section: Discussionmentioning

confidence: 99%

Extended Injection Intervals of Gonadotropins With Superficial Skin Administration In Ivf Treatment Is both Cost-Effective and Patient-Friendly

Hsu

2020

Preprint

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BackgroundWomen undergoing IVF treatments have to receive daily injections of rFSH for multiple follicles growth based on the short half-life of rFSH administered subcutaneously. This study was designed to assess if longer intervals of injection, based on rFSH half-life of 102 hours under superficial subcutaneous administration, effective for women receiving IVF.MethodsOne hundred women, aged 25–45, requesting IVF treatments from January to December 2018 were recruited in this observatory study. All women received long protocol employing GnRH-agonist since day 18 of the previous cycle. An initial bolus of 900 IU rFSH was injected into superficial subcutaneous skin at day 2 of the treatment cycle followed by longer intervals with added doses at day 7 and/or day 10. The main outcomes included the dose of gonadotropin and numbers of injection, serum FSH level, and mature oocytes retrieved.ResultsA total of 70 women completed the treatments, in which 10, 30, and 30 women received one, two and three injections of rFSH, respectively. On average, 2.31 ± 0.73 numbers of Gn injection and 1662 ± 397 IU of rFSH were administered. In comparison with baseline FSH level of 5.6 ± 2.2 IU/L, the serum concentrations of FSH were 35.3 ± 7.0 to 10.7 ± 3.7 IU/L at 1 to 5 days after an initial 900 IU rFSH administration. There were 10.5 ± 6.6 mature oocytes retrieved which resulted in 7.3 ± 5.1 two pronuclei embryos, and 1.8 ± 0.6 embryos were transferred back to the uterus and the remaining embryos were cryopreserved. In total, 72%, 91%, and 31% were noted for fertilization, cleavage, and implantation rates, respectively. The cumulative live birth rate was 36%.ConclusionsBased on the serum FSH levels detected, rFSH only needs to be administered every five days instead of daily injection. This administration mode with less injections and much less expenses for gonadotropin might reach the goal of a more patient-friendly and cost-effective treatment for IVF. Regarding higher response and efficacy of the present study, this administration mode could be employed in women with poor ovarian reserve and in women of poor or suboptimal ovarian response.Trial registration: None

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Total follicle stimulating hormone dose is negatively correlated with live births in a donor/recipient model with fresh transfer: an analysis of 8,627 cycles from the Society for Assisted Reproductive Technology Registry

Cited by 17 publications

References 20 publications

Multivariate analysis of oocyte donor and recipient factors affecting cumulative live birth rate in oocyte donor IVF (OD-IVF) cycles

Multivariate analysis of oocyte donor and recipient factors affecting cumulative live birth rate in oocyte donor IVF (OD-IVF) cycles

Individualized follitropin delta dosing reduces OHSS risk in Japanese IVF/ICSI patients: a randomized controlled trial

Extended Injection Intervals of Gonadotropins With Superficial Skin Administration In Ivf Treatment Is both Cost-Effective and Patient-Friendly

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