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“…We and others have also demonstrated that the PI3K/PTEN/AKT/mTORC1 pathway is involved in drug-resistance of various cancer types and abrogation of cytokine- dependence of hematopoietic cells [ 5 , 6 , 10 12 , 16 , 20 , 24 , 27 30 , 33 , 35 , 36 , 38 41 , 43 55 , 60 , 63 , 65 , 67 , 80 82 ]. The effects of targeting the PI3K/PTEN/Akt/mTORC1 pathway were also examined (Figure 3 ).…”
Section: Resultsmentioning
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“…We and others have also demonstrated that the PI3K/PTEN/AKT/mTORC1 pathway is involved in drug-resistance of various cancer types and abrogation of cytokine- dependence of hematopoietic cells [ 5 , 6 , 10 12 , 16 , 20 , 24 , 27 30 , 33 , 35 , 36 , 38 41 , 43 55 , 60 , 63 , 65 , 67 , 80 82 ]. The effects of targeting the PI3K/PTEN/Akt/mTORC1 pathway were also examined (Figure 3 ).…”
Section: Resultsmentioning
“…Low μM concentrations (50 μM) of metformin also protect endothelial cells against high glucose-induced senescence [179]. Senescence can also be blocked by gerosuppressants/geroprotectors, such as rapamycin, that target mTOR and suppresses growth [313,314]. The National Institute on Aging Interventions Testing Program has investigated a number of drugs, including rapamycin, to determine whether they prolong lifespan in mice [315].…”
Section: Anti-aging Effects Of Metforminmentioning
“…Interestingly, caloric restriction (one of the few other proven antiaging treatments) also inhibits mTORC1. 92 On one hand, insufficient autophagy causing accumulation of protein aggregates and the failure to recycle mitochondria lead to toxic buildup of protein aggregates; additionally, the failure to recycle mitochondria leads to increased reactive oxygen species generation and additional buildup of protein aggregates. On the other hand, too much autophagy (higher-dose rapamycin) can also lead to cell death, whereby the cell "eats itself.…”
Section: Neurodegenerative Diseases Partial Autophagy and Agingmentioning