J. Neurosci. Res. volume 86, issue 15, P3359-3374 2008 DOI: 10.1002/jnr.21781 View full text
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Seigo Usuki, Yoshihiko Nakatani, Kyoji Taguchi, Tetsuhiro Fujita, Shinya Tanabe, Iku Ustunomiya, Yihua Gu, Shaun A. Cawthraw, Diane G. Newell, Mohanasundari Pajaniappan, Stuart A. Thompson, Toshio Ariga, Robert K. Yu

Abstract: An infecting strain VLA2/18 of Campylobacter jejuni was obtained from an individual with campylobacteriosis and used to prepare chicken sera by experimental infection to investigate the role of serum anti-ganglioside antibodies in Guillain-Barré syndrome. Both sera of the patient and chicken contained anti-ganglioside antibodies and anti-Lipid A (anti-Kdo2-Lipid A) antibodies directed against the lipid A portion of the bacterial lipooligosaccharide. The anti-Kdo2-Lipid A activities inhibited voltage-gated Na …

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