Topography of Dopamine Transporter Availability in Progressive Supranuclear Palsy

Discriminating among degenerative parkinsonisms using advanced 123I-ioflupane SPECT analyses

“…Globally, the dopaminergic nigrostriatal pathway seems to be more severely affected in PSP than in PD ( Brooks et al, 1990 ). In agreement with our results, a previous [ 123 I]β-CIT SPECT study in 14 PSP patients and 17 PD patients demonstrates a significantly lower signal in the caudate nuclei in the PSP group ( Seppi et al, 2006 ).…”

Discriminating among degenerative parkinsonisms using advanced 123I-ioflupane SPECT analyses

“…Globally, the dopaminergic nigrostriatal pathway seems to be more severely affected in PSP than in PD ( Brooks et al, 1990 ). In agreement with our results, a previous [ 123 I]β-CIT SPECT study in 14 PSP patients and 17 PD patients demonstrates a significantly lower signal in the caudate nuclei in the PSP group ( Seppi et al, 2006 ).…”

Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study

“…Our data show that SERT levels are dramatically compromised in DLB patients compared with PD or ET patients and HC. SERT levels were also downregulated in PSP patients, in agreement with previous findings 32. On the other hand, PD patients displayed a trend toward a mild decrease in SERT levels.…”

Combined Use of 123i-fp-cit Spect and 123i-mibg Scintigraphy for Differentiation of Progressive Supranuclear Palsy Subtypes and Parkinson's Disease

“…Regarding PSP-RS, the results of the VOI analyses, namely a lower striatal anteroposterior ratio and midbrain SBR as compared with PD, were consistent with those of previous studies [6,8,9]. PSP-RS tends to have a more anterior dominant and profound low striatal SBR than that of PD [6].…”

Discriminating among degenerative parkinsonisms using advanced 123I-ioflupane SPECT analyses

“…Globally, the dopaminergic nigrostriatal pathway seems to be more severely affected in PSP than in PD ( Brooks et al, 1990 ). In agreement with our results, a previous [ 123 I]β-CIT SPECT study in 14 PSP patients and 17 PD patients demonstrates a significantly lower signal in the caudate nuclei in the PSP group ( Seppi et al, 2006 ).…”

Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study

“…Our data show that SERT levels are dramatically compromised in DLB patients compared with PD or ET patients and HC. SERT levels were also downregulated in PSP patients, in agreement with previous findings 32. On the other hand, PD patients displayed a trend toward a mild decrease in SERT levels.…”

Combined Use of 123i-fp-cit Spect and 123i-mibg Scintigraphy for Differentiation of Progressive Supranuclear Palsy Subtypes and Parkinson's Disease

“…Regarding PSP-RS, the results of the VOI analyses, namely a lower striatal anteroposterior ratio and midbrain SBR as compared with PD, were consistent with those of previous studies [6,8,9]. PSP-RS tends to have a more anterior dominant and profound low striatal SBR than that of PD [6].…”

Discriminating among degenerative parkinsonisms using advanced 123I-ioflupane SPECT analyses

“…Globally, the dopaminergic nigrostriatal pathway seems to be more severely affected in PSP than in PD ( Brooks et al, 1990 ). In agreement with our results, a previous [ 123 I]β-CIT SPECT study in 14 PSP patients and 17 PD patients demonstrates a significantly lower signal in the caudate nuclei in the PSP group ( Seppi et al, 2006 ).…”

Midbrain SERT in degenerative parkinsonisms: A 123I‐FP‐CIT SPECT study

“…Our data show that SERT levels are dramatically compromised in DLB patients compared with PD or ET patients and HC. SERT levels were also downregulated in PSP patients, in agreement with previous findings 32. On the other hand, PD patients displayed a trend toward a mild decrease in SERT levels.…”

Combined Use of 123i-fp-cit Spect and 123i-mibg Scintigraphy for Differentiation of Progressive Supranuclear Palsy Subtypes and Parkinson's Disease

“…Regarding PSP-RS, the results of the VOI analyses, namely a lower striatal anteroposterior ratio and midbrain SBR as compared with PD, were consistent with those of previous studies [6,8,9]. PSP-RS tends to have a more anterior dominant and profound low striatal SBR than that of PD [6].…”