Topical Tretinoin, Lung Cancer, and Lung-Related Mortality

Katz, Kenneth A.

doi:10.1001/archderm.144.7.945

Cited by 10 publications

(5 citation statements)

References 6 publications

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“…The aim of the 2005 Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) trial was to investigate if topical tretinoin could prevent non‐melanoma skin cancer . The trial was terminated early because of a higher mortality rate in the active group compared with the control group, a result that caused much discussion as to whether this was a real effect or not . A systematic review therefore investigated the noncutaneous adverse effect of topical tretinoin prior to the VATCC trial.…”

Section: Treatments: Topicalmentioning

confidence: 99%

What's new in acne? An analysis of systematic reviews published in 2011-2012

Bhate

Williams

2014

Clin Exp Dermatol

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This review summarizes important clinical developments in acne vulgaris identified from 17 systematic reviews published between February 2011 and August 2012. Regarding causes, Demodex mites have been shown to be associated with both acne vulgaris and rosacea, although it is unclear if their eradication improves either disease. Some weak evidence has emerged that suggests a possible link between dairy produce and acne, which warrants further research. With reference to the effects of acne, there is good evidence that acne negatively affects quality of life, self-esteem and mood in adolescents. Acne is also associated with an increased risk of anxiety, depression and suicidal ideation, highlighting the importance of asking patients with acne directly about psychological issues in order to identify those who might benefit from early psychiatric support. Regarding treatment, there seems to be no additional benefit to using higher strengths of benzoyl peroxide, and lower strengths such as 2.5% have fewer side effects. Despite earlier concerns of increased mortality in those using topical tretinoin for skin cancer prevention, a systematic review on this topic has not found any convincing evidence of a link between such non-cutaneous events and once-daily application of 0.02-0.05% tretinoin. Combined oral contraceptives are of benefit in both inflammatory and non-inflammatory acne. Current surveys suggest that implementation of the pregnancy prevention programme for isotretinoin may not be stringent, and a high level of monitoring and audit is recommended. Ablative and non-ablative laser resurfacing for the treatment of acne scars may be beneficial, but further studies with a longer follow-up period are required.

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Section: Treatments: Topicalmentioning

confidence: 99%

What's new in acne? An analysis of systematic reviews published in 2011-2012

Bhate

Williams

2014

Clin Exp Dermatol

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“…Effects of topical tretinoin and topical retinoid-antibiotic combinations have been controversial, with some literature showing potentially variable ocular and systemic absorption and effects. 22 , 24 , 25 , 26 , 27 , 28 , 29 , 30 A prospective study of 43 patients starting daily topical retinoid-erythromycin for facial acne vulgaris found significant development of ocular surface disease and dry eye after one month of use. 9 The authors hypothesized that acne vulgaris patients may have altered local systemic absorption due to diseased skin and/or facial topical retinoid may be present in facial sweat running into the eyelids and possibly contaminate the eye.…”

Section: Discussionmentioning

confidence: 99%

Oral isotretinoin and topical retinoid use in a series of young patients with ocular melanoma

Mishra

Scholey

Daftari

et al. 2020

American Journal of Ophthalmology Case Reports

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Purpose To describe the first series of six young uveal melanoma (UM) patients with oral isotretinoin and/or topical retinoid therapy prior to diagnosis. Observations The case series is based on clinical observations at our UM quaternary referral center. Six UM patient cases are reported, ages 16–44 years old. All had been using either oral (isotretinoin) and/or topical (tretinoin or tazarotene) retinoid treatment (3 months–~10 years) prior to or at the time of diagnosis (3 of 6 cases). All patients had ocular complaints on presentation, and the onset of certain symptoms corresponded with the course of retinoids. Other potential risk factors or relevant history included Caucasian background, cone-rod dystrophy and active smoker status (Case 2), family history of UM and pregnancy at time of diagnosis (Case 3), past smoking and possible secondary Chernobyl exposure as a baby (Case 5). All patients were treated with proton beam radiotherapy and currently have no sign of recurrent or metastatic disease. Conclusions and importance Retinoid therapy has been linked to various benign and/or reversible effects on the anterior and posterior eye, though pathophysiology remains not well understood. Uveal melanoma (UM) is a rare cancer diagnosis in young adults. We report here the first case series of young UM patients with a history of retinoid use and ocular complaints. No causal link is claimed and further systematic epidemiologic and biologic study of retinoid therapy and ocular impact may provide additional relevant data, particularly in young ocular melanoma patients.

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“…1 The Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) trial 2 was a double-blind study conducted to assess the value of tretinoin, 0.1%, cream in the prevention of nonmelanoma skin cancer. 1 The Veterans Affairs Topical Tretinoin Chemoprevention (VATTC) trial 2 was a double-blind study conducted to assess the value of tretinoin, 0.1%, cream in the prevention of nonmelanoma skin cancer.…”

Topical Tretinoin, Lung Cancer, and Lung-Related Mortality

Cited by 10 publications

References 6 publications

What's new in acne? An analysis of systematic reviews published in 2011-2012

What's new in acne? An analysis of systematic reviews published in 2011-2012

Oral isotretinoin and topical retinoid use in a series of young patients with ocular melanoma

Tretinoin: An Established Long-term Safety Profile—Reply

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