1991
DOI: 10.1001/archderm.127.5.659
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Topical tretinoin for treatment of photodamaged skin. A multicenter study

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Cited by 91 publications
(75 citation statements)
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“…Topical tazarotene also induced favorable histologic changes in photodamaged skin, similar to those described in an earlier pilot study and those described for tretinoin. 1,4,10 These changes were significant when compared with baseline and included increases in epidermal thickness and decreases in melanin content. No increases in cellular atypia in either keratinocytes or melanocytes were observed with topical retinoid treatment.…”
Section: Commentmentioning
confidence: 96%
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“…Topical tazarotene also induced favorable histologic changes in photodamaged skin, similar to those described in an earlier pilot study and those described for tretinoin. 1,4,10 These changes were significant when compared with baseline and included increases in epidermal thickness and decreases in melanin content. No increases in cellular atypia in either keratinocytes or melanocytes were observed with topical retinoid treatment.…”
Section: Commentmentioning
confidence: 96%
“…Excluded were any volunteers who had used topical glycolic acid, ␣-hydroxy acid, salicylic acid, lactic acid, or ␤-hydroxy acid or vitamin A, ascorbic acid-, or vitamin E-containing products within 14 days before study enrollment and those who had used topical or systemic retinoids within 6 months before study enrollment. Pregnant and nursing women were excluded, and women of childbearing potential were required to use a reliable form of contraception, have a normal menstrual cycle, and have a negative urine pregnancy test result at baseline (week 0) and at weeks 4,8,12,16,20, and 24. Written informed consent was obtained from all subjects, and the study was conducted in compliance with Good Clinical Practices, Institutional Human Review Board Regulations, and the Declaration of Helsinki.…”
Section: Study Populationmentioning
confidence: 99%
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“…6-month trials have been conducted with topi cal tretinoin emollient cream. The first study [21] compared the effects of treatment with 0.05 or 0.01 % formulations to treatment with vehicle in 251 evaluable subjects with mildto-moderate photodamage. Dose-related re sponses in global improvement were ob served: excellent, good or fair response in 86% of patients on 0.05% and 61 % on 0.01 % treti noin emollient cream compared to 44% of patients in the vehicle group (p < 0.001 and p = 0.047, respectively).…”
Section: Treatment With Topical Tretinoinmentioning
confidence: 99%