Topical Therapy of Psoriasis with Fluocinolone Acetonide

Effects of Skin Occlusion on Percutaneous Absorption: An Overview

“…Skin occlusion can increase stratum corneum hydration, and hence influence percutaneous absorption by altering partitioning between the surface chemical and the skin due to the increasing presence of water, swelling corneocytes and possibly altering the intercellular lipid phase organization, also by increasing the skin surface temperature, and increasing blood flow [2][3][4]. Occlusion may enhance drug efficacy [5][6][7][8][9][10]. Ac- Zhai/Maibach tually, skin occlusion is a complex event producing profound changes and influencing skin biology as well as wound healing processes [11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Comparative Effects of Current Topical Corticosteroids

“…The method is simple, has few untoward reactions, pro¬ duces no systemic effects and results in more rapid improvement than other current modes of therapy, including intralesional injections. Scholtz,2 and Sulzberger and Witten3 ap¬ plied various topical corticosteroid prep¬ arations under plastic film and obtained excellent results. Among other reasons they attributed the enhanced effect to closer con¬ tact between the ointment and skin, and better absorption due to increased macera¬ tion and hydration of the epidermis.…”

Flurandrenolone Lotions for Surface Depot Therapy. Detailed Assay and Clinical Studies

“…O ne o f th e significant ad v an ces in topical th e ra p y w ith co rtico stero id s h as b een th e use of occlusive dressings w ith v arious steroids [1,2,3,4,5]. T h e technics h av e b een described in d etail.…”