2002
DOI: 10.1001/archderm.138.11.1421
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Topical Targretin and Intralesional Interferon Alfa for Cutaneous Lymphoma of the Scalp

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Cited by 16 publications

(11 citation statements)
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“…Radiotherapy alone has been used in patients with localized B-cell PCNHL with the relapse rates ranging between 32% and 100% (3,(9)(10)(11). There are reports of intralesional administration of interferon alfa, cisplatin and bexarotene (tegretin) (11,12). Zenone et al presented one patient who had complete remission with intralesional interferon alfa ( 11).…”
Section: Discussionmentioning
confidence: 99%
“…Bexarotene applied locally or in form of gel has shown results in the treatment of T cell lymphoma, acquired immunodeficiency Kaposi-sarcoma and one case diffuse large B-cell of the scalp (11)(12)(13)(14). Systemic chemotherapy including doxorubicin, cyclophospahmide, vincristine and prednisone as monotherapy or in combination as protocol COP (cyclophospahmide, vincristine and prednisone) or CHOP (doxorubicin, cyclophospahmide, vincristine and prednisone) achieved response in 98% but relapse rate was 33% (3,12,15). A multicenter prospective clinical study of 49 PCNHL patients with combination chemotherapy reported event-free survival of 50% at 5 years after treatment (16).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Radiotherapy alone has been used in patients with localized B-cell PCNHL with the relapse rates ranging between 32% and 100% (3,(9)(10)(11). There are reports of intralesional administration of interferon alfa, cisplatin and bexarotene (tegretin) (11,12). Zenone et al presented one patient who had complete remission with intralesional interferon alfa ( 11).…”
Section: Discussionmentioning
confidence: 99%
“…Bexarotene applied locally or in form of gel has shown results in the treatment of T cell lymphoma, acquired immunodeficiency Kaposi-sarcoma and one case diffuse large B-cell of the scalp (11)(12)(13)(14). Systemic chemotherapy including doxorubicin, cyclophospahmide, vincristine and prednisone as monotherapy or in combination as protocol COP (cyclophospahmide, vincristine and prednisone) or CHOP (doxorubicin, cyclophospahmide, vincristine and prednisone) achieved response in 98% but relapse rate was 33% (3,12,15). A multicenter prospective clinical study of 49 PCNHL patients with combination chemotherapy reported event-free survival of 50% at 5 years after treatment (16).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Most often “B” symptoms (night sweats, fever, and unintentional weight loss) are not noticed until the advanced stage of lymphoma [ 24 , 28 , 31 , 37 , 41 , 58 , 63 , 70 , 76 , 80 , 92 , 96 , 101 , 102 , 107 , 111 , 112 , 117 , 143 ]. Lymphadenopathy may be present and it is essential to carefully examine the lymph nodes of the palpable areas [ 2 , 13 , 20 , 21 , 24 , 28 , 30 , 33 , 34 , 37 , 42 , 43 , 48 , 49 , 52 , 53 , 57 , 58 , 62 , 63 , 66 , 70 , 71 , 72 , 73 , 74 , 76 , 77 , 84 , 86 , 89 , 92 , 94 , …”
Section: Diagnosismentioning
confidence: 99%
“…Lymphadenopathy may be present and it is essential to carefully examine the lymph nodes of the palpable areas [ 2 , 13 , 20 , 21 , 24 , 28 , 30 , 33 , 34 , 37 , 42 , 43 , 48 , 49 , 52 , 53 , 57 , 58 , 62 , 63 , 66 , 70 , 71 , 72 , 73 , 74 , 76 , 77 , 84 , 86 , 89 , 92 , 94 , 97 , 99 , 102 , 103 , 104 , 109 , 114 , 116 , 118 , 119 , 135 , 138 , 143 , 145 , 146 , 147 ]. Laboratory test results are also within normal limits in the early stages of the disease [ 6 , 19 , 24 , 28 ...…”
Section: Diagnosismentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“……”
Section: Combination Therapymentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.