Topical sodium cromoglicate relieves allergen- and histamine-induced dermal pruritus

Santos, R. Vieira dos; Magerl, Markus; Martus, Peter; Zuberbier, Torsten; Church, Martin K.; Escribano, Luís; Maurer, Marcus

doi:10.1111/j.1365-2133.2009.09516.x

Cited by 63 publications

(37 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3) Successful cross-breeding of mice that spontaneously develop AA-like lesions (C3H/HeJ mice) with MC-deficient mouse strains [118] has not yet been achieved by any group. 4) Frequently employed inhibitors of MC degranulation such as cromolyn or luteolyn are not effective for all MC subsets and/or are not MC-specific, as other cell populations, including CD8+ T-cells and sensory neurons and their axons, are also affected [119]–[122].…”

Section: Discussionmentioning

confidence: 99%

Abnormal Interactions between Perifollicular Mast Cells and CD8+ T-Cells May Contribute to the Pathogenesis of Alopecia Areata

Bertolini

Zilio²,

Rossi³

et al. 2014

PLoS ONE

127

130

View full text Add to dashboard Cite

Alopecia areata (AA) is a CD8+ T-cell dependent autoimmune disease of the hair follicle (HF) in which the collapse of HF immune privilege (IP) plays a key role. Mast cells (MCs) are crucial immunomodulatory cells implicated in the regulation of T cell-dependent immunity, IP, and hair growth. Therefore, we explored the role of MCs in AA pathogenesis, focusing on MC interactions with CD8+ T-cells in vivo, in both human and mouse skin with AA lesions. Quantitative (immuno-)histomorphometry revealed that the number, degranulation and proliferation of perifollicular MCs are significantly increased in human AA lesions compared to healthy or non-lesional control skin, most prominently in subacute AA. In AA patients, perifollicular MCs showed decreased TGFβ1 and IL-10 but increased tryptase immunoreactivity, suggesting that MCs switch from an immuno-inhibitory to a pro-inflammatory phenotype. This concept was supported by a decreased number of IL-10+ and PD-L1+ MCs, while OX40L+, CD30L+, 4–1BBL+ or ICAM-1+ MCs were increased in AA. Lesional AA-HFs also displayed significantly more peri- and intrafollicular- CD8+ T-cells as well as more physical MC/CD8+ T-cell contacts than healthy or non-lesional human control skin. During the interaction with CD8+ T-cells, AA MCs prominently expressed MHC class I and OX40L, and sometimes 4–1BBL or ICAM-1, suggesting that MC may present autoantigens to CD8+ T-cells and/or co-stimulatory signals. Abnormal MC numbers, activities, and interactions with CD8+ T-cells were also seen in the grafted C3H/HeJ mouse model of AA and in a new humanized mouse model for AA. These phenomenological in vivo data suggest the novel AA pathobiology concept that perifollicular MCs are skewed towards pro-inflammatory activities that facilitate cross-talk with CD8+ T-cells in this disease, thus contributing to triggering HF-IP collapse in AA. If confirmed, MCs and their CD8+ T-cell interactions could become a promising new therapeutic target in the future management of AA.

show abstract

Section: Discussionmentioning

confidence: 99%

Abnormal Interactions between Perifollicular Mast Cells and CD8+ T-Cells May Contribute to the Pathogenesis of Alopecia Areata

Bertolini

Zilio²,

Rossi³

et al. 2014

PLoS ONE

127

130

View full text Add to dashboard Cite

show abstract

“…In patients with predominantly gastrointestinal symptoms but also with symptoms of musculoskeletal pain, fatigue, and headache, therapy with oral and inhaled sodium cromolyn may be tried, as noted in a case report [43]. An exploratory study in 20 allergic and 40 nonallergic individuals in whom aqueous cream containing sodium cromoglycate was applied before skin prick test with allergens, codeine, and histamine suggests that this medication may be effective in reducing pruritus [44]. In another trial, the lipid raft modulator miltefosine showed a trend toward reducing the volume of wheals in 39 adult patients with skin involvement of mastocytosis after topical therapy [45], but it cannot yet be recommended.…”

Section: Therapy For Cutaneous and Indolent Systemic Mastocytosismentioning

confidence: 91%

Update on Diagnosis and Treatment of Mastocytosis

Brockow

Ring

2011

Curr Allergy Asthma Rep

View full text Add to dashboard Cite

Mastocytosis is a disorder characterized by increased numbers of mast cells in tissues. Recent clinical observations highlight the association of mastocytosis with an increased risk of anaphylaxis and underline the diversity of this disease. At the molecular level, recent studies have attempted to unravel specific gene expression profiles for activating c-kit mutations in the etiology of mastocytosis. The diagnosis may be facilitated by surrogate markers and detection of aberrant immunophenotypic surface markers. New therapeutic strategies are in development based on intracellular signal pathways, or on application of topical treatments, as are novel forms of cytoreductive therapy, including tyrosine kinase inhibitors.

show abstract

“…B. Loratadin, Cetirizin, Desloratadin, Levocetirizin, täglich oder bei Bedarf) meist gut beherrschbar [1,4]. Weiterhin haben sich topische Substanzen wie Polidocanol oder Cromoglycinsäure in der antipruritischen Therapie bewährt [27]. Großflächige symptomatische Plaques und Knoten sowie solitäre Mastozytome können kurzfristig mit topischen Kortikosteroiden behandelt werden.…”

Section: Therapieunclassified

Mastozytosen im Kindesalter

et al. 2012

Self Cite

View full text Add to dashboard Cite

Mastocytoses are a group of rare diseases characterized, in most cases, by a benign proliferation and accumulation of mast cells in different tissues. In children, mastocytosis affects usually exclusively the skin and differs in many aspects from adult-onset mastocytosis. Except for diffuse cutaneous mastocytosis, which is an uncommon subtype of childhood-onset mastocytosis, involvement of the bone marrow or additional extracutaneous organs is rarely seen in children. The prognosis of childhood-onset mastocytosis is usually very good. Compared to adult patients who most commonly experience chronic-stable or slowly progressive disease, mastocytosis in children is mostly transient and self-limiting. In this review, we present and discuss the subtypes of childhood-onset mastocytosis, recent advances in the understanding of their pathogenesis as well as similarities and differences between adult- and childhood-onset mastocytosis.

show abstract

Topical sodium cromoglicate relieves allergen- and histamine-induced dermal pruritus

Cited by 63 publications

References 18 publications

Abnormal Interactions between Perifollicular Mast Cells and CD8+ T-Cells May Contribute to the Pathogenesis of Alopecia Areata

Abnormal Interactions between Perifollicular Mast Cells and CD8+ T-Cells May Contribute to the Pathogenesis of Alopecia Areata

Update on Diagnosis and Treatment of Mastocytosis

Mastozytosen im Kindesalter

Contact Info

Product

Resources

About