Topical Negative Pressure Devices

Shirakawa, Miki; Isseroff, Roslyn Rivkah

doi:10.1001/archderm.141.11.1449

Cited by 36 publications

(6 citation statements)

References 24 publications

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“…• Both foam and gauze have been shown to be equally effective at wound contraction and stimulation of blood flow at the wound edge [5]. Foam has been shown to provide rapid granulation, but this can be offset by in-growth with potential to disturb the epithelialization process and also be painful when the foam is changed [6][7][8][9].…”

Section: Primary Mechanismsmentioning

confidence: 99%

Negative pressure wound therapy… A healing touch approach to difficult wounds in orthopedic practice… A systematic review

2020

OJOT

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Section: Primary Mechanismsmentioning

confidence: 99%

Negative pressure wound therapy… A healing touch approach to difficult wounds in orthopedic practice… A systematic review

2020

OJOT

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“…Wound cells respond to these changes (Hinz, 2010), and increasing evidence links wound pathogenesis to alterations in ECM compliance and mechanical tension within the wound bed (Wong et al, 2011). Such alterations may be caused by changes in cell-generated forces, defective ECM deposition, or mis-regulated proteolysis of the ECM (Hermes et al, 2011; Lancerotto et al, 2012; Shirakawa and Isseroff, 2005; Trengove et al, 1999; Wong et al, 2013). …”

Section: Potential Mechanisms Of Integrin-mediated Long-distance Sigmentioning

confidence: 99%

Integrin-mediated regulation of epidermal wound functions

et al. 2016

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During cutaneous wound healing, keratinocyte proliferation and migration are critical for re-epithelialization. In addition, the epidermis secretes growth factors, cytokines, proteases, and matricellular proteins into the wound microenvironment that modify the extracellular matrix and stimulate other wound cells that control the inflammatory response, promote angiogenesis, and facilitate tissue contraction and remodeling. Wound keratinocytes express at least seven different integrins - the major cell adhesion receptors for the extracellular matrix - that collectively control essential cell-autonomous functions to ensure proper re-epithelialization, including migration, proliferation, survival, and basement membrane assembly (Fig. 1, arrow 1). Moreover, it has become evident in recent years that some integrins can regulate paracrine signals from wound epidermis that stimulate other wound cells involved in angiogenesis, contraction and inflammation (Fig. 1, arrows 2 and 3). Importantly, it is likely that abnormal integrin expression or function in the epidermis contributes to wound pathologies such as over-exuberant healing (e.g., hypertrophic scar formation) or diminished healing (e.g., chronic wounds). In this review, we discuss current knowledge of integrin function in the epidermis, which implicates them as attractive therapeutic targets to promote wound healing or treat wound pathologies. We also discuss challenges that arise from the complex roles that multiple integrins play in wound epidermis, which may be regulated through extracellular matrix remodeling that determines ligand availability. Indeed, understanding how different integrin functions are temporally coordinated in wound epidermis, and which integrin functions go awry in pathological wounds, will be important to determine how best to target them clinically to achieve maximum therapeutic benefit.

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“…This may cause patients to experience pain during dressing changes and disturb the re-epithelialisation process. [34][35][36][37] Proper wound healing by granulation may be inhibited by the remaining fibres of the dressing. Using wound contact layers helps eliminate in-growth and pain.…”

Section: Does the Exudate Removal Reduce The Amount Of Infectious mentioning

confidence: 99%

Modern alternative or first-line treatment: How to safely use Negative Pressure Wound Therapy in Diabetic Foot Syndrome?

Mrozikiewicz-Rakowska

Bucior

Kania

et al. 2015

NPWTJ

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Clinical experience and basic science studies show that Negative Pressure Wound Therapy (NPWT) is a promising yet still under-used treatment method for patients with diabetic foot syndrome (DFS). Despite its advantages, it may carry the risk of serious side effects if the indications and contraindications are not strictly observed. The aim of this article is to discuss myths and facts about NPWT in conditions such as: inadequate blood supply, insufficient wound debridement, osteomyelitis or the necessity to monitor laboratory parameters during the therapy. We will try to define the optimal conditions for NPWT in order to obtain better results and eliminate the risk of side effects.

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Topical Negative Pressure Devices

Cited by 36 publications

References 24 publications

Negative pressure wound therapy… A healing touch approach to difficult wounds in orthopedic practice… A systematic review

Negative pressure wound therapy… A healing touch approach to difficult wounds in orthopedic practice… A systematic review

Integrin-mediated regulation of epidermal wound functions

Modern alternative or first-line treatment: How to safely use Negative Pressure Wound Therapy in Diabetic Foot Syndrome?

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