Topical metronidazole therapy for rosacea

Bleicher, P. A.

doi:10.1001/archderm.123.5.609

Cited by 29 publications

(32 citation statements)

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“…Since no change occurred in telangiectasia and rhinophyma, we thought that permethrin 5% cream and metronidazole 0.75% gel had no effect on telangiectasia and rhinophyma and, therefore, did not make any statistical analysis of telangiectasia and rhinophyma scores. Our finding that metronidazole 0.75% gel did not have any effect on telangiectasia and rhinophyma was consistent with the results of previous studies [4, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29]. …”

Section: Discussionsupporting

confidence: 93%

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

et al. 2002

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Background: Permethrin 5% cream used against human ectoparasites suggests that it may be effective in papulopustular rosacea. Methods: This study included 63 patients diagnosed as having papulopustular rosacea based on the clinical and histological findings. Patients were randomly assigned into permethrin (n = 23), metronidazole (n = 20) and placebo (n = 20) groups. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and Demodex folliculorum were determined. Twenty-three patients were given permethrin 5% cream (Zalvor 5% skin cream^®), 20 patients metronidazole 0.75% gel (Roza gel^®) and 20 patients placebo cream (Basis cream^®), in packages looking identical to those of metronidazole and permethrin creams, and were recommended to apply them to their faces twice a day. All patients were also given SPF 20 cream for protection against sunlight. Two months of treatment were planned, and the patients were invited to the clinic for fortnightly controls. Scores of erythema, telangiectasia, edema and rhinophyma and the numbers of papules, pustules, inflammatory nodules and D. folliculorum were recorded at each visit. The mean scores of erythema and the mean numbers of papules, pustules and D. folliculorum were determined at baseline and on days 15, 30, 45 and 60. Side effects were also detected. Results: The effect of permethrin 5% cream on D. folliculorum was superior to that of metronidazole 0.75% gel. The effect of permethrin 5% cream on erythema and papules was found to be more effective than placebo and as effective as metronidazole 0.75% gel. However, it had no effect on telangiectasia, rhinophyma and pustules. Conclusion: It can be concluded that the application of permethrin 5% cream twice daily for 2 months can be as effective and reliable as metronidazole in the treatment of rosacea and a greater benefit can be gained when it is combined with other systemic and/or topical treatments.

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Section: Discussionsupporting

confidence: 93%

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

et al. 2002

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“…It has been shown to inhibit the anaerobic growth of Propionibacterium acnes and the generation of neutrophil reactive oxygen species in vitro when combined with palmitoleic acid (which is generally present in the skin), which may be the basis of its clinical effectiveness [6]. Metronidazole gel has been found to be safe and effective in treating rosacea [7, 8]. Recently, it has been shown that continued treatment with metronidazole gel alone maintains remission of moderate to severe rosacea [9].…”

Section: Discussionmentioning

confidence: 99%

Topical Metronidazole in Seborrheic Dermatitis – A Double-Blind Study

et al. 2001

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Objective: To evaluate the role of topical metronidazole gel in the treatment of seborrheic dermatitis. Methods: Forty-four patients with seborrheic dermatitis were enrolled in the study. All topical treatments were stopped for at least 2 weeks before the patients were allocated at random to receive either metronidazole 1% gel or placebo for 8 weeks. The severity score was measured at the initial evaluation, and the patients were followed up at 2-week intervals for 8 weeks. A global evaluation of improvement was done at 8 weeks. Results: Thirty-eight patients completed the study; 21 patients in the metronidazole group and 17 patients in the placebo group could be evaluated. There was a statistically significant decrease of the mean score even at week 2; the difference became highly significant at 8 weeks (p < 0.001). On the final evaluation at 8 weeks, 14 patients in the metronidazole group showed marked improvement to complete clearance as compared to only 2 patients having moderate improvement in the placebo group (p < 0.001). Conclusion: The present trial has demonstrated the effectiveness of topical 1% metronidazole gel in seborrheic dermatitis.

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“…[3][4][5][6][7][8][9][10] Sometimes, both systemic antibiotics and topical metronidazole are used together at first. Once rosacea improves, the oral antibiotic regimen may be discontinued with the hope that topical application of metronidazole will maintain the remission.…”

Section: Discussionmentioning

confidence: 99%

Topical Metronidazole Maintains Remissions of Rosacea

Mv¹,

Hi²,

Gg³

et al. 1998

Arch Dermatol

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Topical metronidazole therapy for rosacea

Cited by 29 publications

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Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

Permethrin 5% Cream versus Metronidazole 0.75% Gel for the Treatment of Papulopustular Rosacea

Topical Metronidazole in Seborrheic Dermatitis – A Double-Blind Study

Topical Metronidazole Maintains Remissions of Rosacea

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