Topical mechlorethamine. Cutaneous changes in patients with mycosis fungoides after its administration

Abstract

Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years. Clinical and histological studies for radiomimetic and radiodermatitis-like effects failed to demonstrate any abnormalities. The only observed changes were generalized hyperpigmentation of the skin and melanin-containing melanophages in the papillary dermis. We consider that the long-term use of topical mechlorethamine may be a safe form of therapy, but that a continuous indefinite follow-up of patients on this medication should be mandatory.

Treatment of Alopecia Areata with Topical Nitrogen Mustard

“…Topical treatment with HN2 is a relatively safe form of therapy. 6 We have not observed any serious local or systemic harmful effects in our patients. We would advocate that all patients treated with this medication be closely followed for a long period.…”

Cutaneous T-cell lymphoma in skin of color

“…Histologically and ultrastructurally, this hyperpigmentation corresponds to increased size and number of otherwise normal melanocytes and dermal melanophages. 55,56 Carmustine or bis-chloroethyl-nitrourea. Another SDT that is independent of skin color and used disproportionately more in MF of skin of color is topical carmustine or BCNU.…”

A Prospective Study of Cutaneous Intolerance to Topical Mechlorethamine Therapy in Patients With Cutaneous T-Cell Lymphomas

“…Short-term adverse reactions include pruritus, xerosis, hyperpigmentation, and less commonly urticaria, bullous reactions, and StevensJohnson syndrome. 3,7,[22][23][24] The most common adverse reaction is CIM, defined by erythema and pruritus at the site of application. [1][2][3] In our study, 23 (53%) of the 43 patients developed CIM; this percentage is similar to those reported in the literature.…”