Topical mechlorethamine. Cutaneous changes in patients with mycosis fungoides after its administration

Abstract

Six patients with mycosis fungoides were treated with topical mechlorethamine hydrochloride for periods of two to four years. Clinical and histological studies for radiomimetic and radiodermatitis-like effects failed to demonstrate any abnormalities. The only observed changes were generalized hyperpigmentation of the skin and melanin-containing melanophages in the papillary dermis. We consider that the long-term use of topical mechlorethamine may be a safe form of therapy, but that a continuous indefinite follow-up of patients on this medication should be mandatory.

Treatment of Alopecia Areata with Topical Nitrogen Mustard

“…Topical treatment with HN2 is a relatively safe form of therapy. 6 We have not observed any serious local or systemic harmful effects in our patients. We would advocate that all patients treated with this medication be closely followed for a long period.…”

Skin-Directed Therapies in Cutaneous T-Cell Lymphoma

“…30,37 However, therapy discontinuation can usually be prevented by application of topical steroids, prior desensitization in the case of an allergic contact dermatitis, or decreasing the concentration of the medication or frequency of application in cases of irritant dermatitis. 31,42,44 A 2005 French study of 64 stage T1 and T2 patients with MF, revealed that combination treatment with topical nitrogen mustard and topical steroids could reduce adverse cutaneous reactions and still be effective. 41 Patients were treated with twice-weekly 0.02% mechlorethamine aqueous solution to the entire skin surface, excluding the head.…”

Cutaneous T-cell lymphoma in skin of color

“…Histologically and ultrastructurally, this hyperpigmentation corresponds to increased size and number of otherwise normal melanocytes and dermal melanophages. 55,56 Carmustine or bis-chloroethyl-nitrourea. Another SDT that is independent of skin color and used disproportionately more in MF of skin of color is topical carmustine or BCNU.…”