Topical Application of Nerve Growth Factor in Human Diabetic Foot Ulcers. A Study of Three Cases

Generini, Sergio; Tuveri, M A; Cerinic, M. Matucci; Mastinu, F.; Manni, Luigi; Aloe, Luigi

doi:10.1055/s-2004-821313

Cited by 56 publications

(36 citation statements)

References 12 publications

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“…In a clinical case series, topical application in 3 recalcitrant ischaemic diabetic foot ulcers has facilitated healing, an effect partly attributed to, though not documented, to stimulation of new vessel formation [41].…”

Section: Therapeutic Angiogenesismentioning

confidence: 97%

Advances in Treating the Ischaemic Diabetic Foot

Παπάνας

Maltezos²

2008

CVP

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The diabetic foot remains a major cause of morbidity worldwide. Ischaemia due to peripheral arterial disease significantly contributes to its pathogenesis and natural history. Increased revascularisation has been decisive in improving outcomes. However, there is still a need for further improvement. Advances in the treatment of ischaemia in the diabetic foot include therapeutic angiogenesis, stem cell therapy and miscellaneous modalities. Angiogenesis has yielded encouraging results in the treatment of peripheral arterial disease, but it has not been studied enough in patients with diabetes. Choice of patients, reliable study endpoints, as well as safety of growth factors in diabetic patients, who have an excess risk of widespread vascular disease, need to be addressed more convincingly. Similar improvement is required in the other emerging therapeutic options. From a practical point of view, until novel modalities are available, increased vigilance and prompt aggressive revascularisation are indispensable to reduce the rate of amputations.

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Section: Therapeutic Angiogenesismentioning

confidence: 97%

Advances in Treating the Ischaemic Diabetic Foot

Παπάνας

Maltezos²

2008

CVP

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“…Topical mNGF has been applied in three diabetic patients affected by on foot ulcers [154]. The treatment induced a local progressive restoration of nerve function and an almost complete relapse of ulcers within 5–14 weeks since the beginning of treatment.…”

Section: Clinical Use Of Ngfmentioning

confidence: 99%

Nerve growth factor: from the early discoveries to the potential clinical use

et al. 2012

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The physiological role of the neurotrophin nerve growth factor (NGF) has been characterized, since its discovery in the 1950s, first in the sensory and autonomic nervous system, then in central nervous, endocrine and immune systems. NGF plays its trophic role both during development and in adulthood, ensuring the maintenance of phenotypic and functional characteristic of several populations of neurons as well as immune cells. From a translational standpoint, the action of NGF on cholinergic neurons of the basal forebrain and on sensory neurons in dorsal root ganglia first gained researcher’s attention, in view of possible clinical use in Alzheimer’s disease patients and in peripheral neuropathies respectively. The translational and clinical research on NGF have, since then, enlarged the spectrum of diseases that could benefit from NGF treatment, at the same time highlighting possible limitations in the use of the neurotrophin as a drug. In this review we give a comprehensive account for almost all of the clinical trials attempted until now by using NGF. A perspective on future development for translational research on NGF is also discussed, in view of recent proposals for innovative delivery strategies and/or for additional pathologies to be treated, such as ocular and skin diseases, gliomas, traumatic brain injuries, vascular and immune diseases.

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“…Clinically, topical application of NGF leads to the repair of neurotrophic corneal ulcers and recovery of corneal surface sensitivity [77,78] and to diabetic foot ulcers [79].…”

Section: Topical Application Of Nerve Growth Factor (Ngf)mentioning

confidence: 99%

Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination

Kuffler¹

2012

TOCVJ

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Pressure ulcers, also called decubitus ulcers, are a common challenge of humanity. They are wounds initiated by pressure on the skin that blocks circulation causing the skin and underlying tissues to die. Without care, pressure ulcers continue to grow in diameter and depth and are exceptionally difficult to heal. They have probably always existed, and are present on Egyptian mummies. Pressure ulcers are a serious health issue, very painful, a significant physiological challenge, can shorten the life of a patient, are an emotional and financial burden to the patient, those who deal with them, and in the United States alone annually costs in excess over $10 billion dollars for care and prolonged hospitalization. Pressure ulcers can develop with as little as two hours of pressure, and because even a brief lapse in avoidance of pressure leads to ulcers, they are frequently impossible to prevent, even for the most conscientious patient with an extensive support group and unlimited financial resources. Therefore, enormous effort is required to find effective and reliable techniques for preventing the initiation of ulcers and eliminating them once they develop. This review looks at the various approaches presently used and in development for the treatment of pressure ulcers, evaluates which may be best in eliminating ulcers, and discusses combinations of techniques that may be most effective in eliminating pressure ulcers.

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Topical Application of Nerve Growth Factor in Human Diabetic Foot Ulcers. A Study of Three Cases

Cited by 56 publications

References 12 publications

Advances in Treating the Ischaemic Diabetic Foot

Advances in Treating the Ischaemic Diabetic Foot

Nerve growth factor: from the early discoveries to the potential clinical use

Techniques for Wound Healing with a Focus on Pressure Ulcers Elimination

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