Topical antibiotics for acne vulgaris. Current usage

Abstract

The following review by Dr

Resistance of propionibacteria to antibiotics used in the treatment of acne

“…Oral clindamycin was introduced in the early 1970's, followed by topical preparations of clindamycin, erythromycin and tetracycline (Resh and Stoughton, 1976;Stoughton, 1979;Adams, Cooke and Cunliffe, 198 1). Several studies have established the efficacy of these topical preparations, particularly clindamycin (Resh and Stoughton, 1976;Adams et al, 1981) which is used extensively in the USA (Stoughton, 1979).…”

“…Oral clindamycin was introduced in the early 1970's, followed by topical preparations of clindamycin, erythromycin and tetracycline (Resh and Stoughton, 1976;Stoughton, 1979;Adams, Cooke and Cunliffe, 198 1). Several studies have established the efficacy of these topical preparations, particularly clindamycin (Resh and Stoughton, 1976;Adams et al, 1981) which is used extensively in the USA (Stoughton, 1979). However, in view of the association between topical and oral therapy with clindamycin and antibiotic-associated pseudomembranous colitis (Cohen, McNeill and Wells, 1973;Milstone, McDonald and Scholhamer, 198 l), care in its use is indicated (Adams et al, 198 1).…”

“…A marked fall in numbers of P . acnes in comedones occurred with clindamycin but not erythromycin therapy although there was clinical improvement with both agents (Resh and Stoughton, 1976;Stoughton, 1979).…”

Prospects for the treatment of acne vulgaris and rosacea*

“…Orr et al (1978) showed that a minor variation on this produced an ideal base for clindamycin (Table i). Other studies have shown this preparation to be very stable with a long shelf-life (Stoughton, 1979). added N-methyl-2-pyrrolidine to this basic vehicle in order to increase penetration of the antibacterial agent and found it to be suitable for tetracycline, clindamycin and erythromycin (Table 2).…”

Topical clindamycin formulations for the treatment of acne vulgaris. An evaluation

“…\s=b\This study evaluated Subjects were instructed to perform the following procedures twice daily: (1) wash with a sulfated, surfactant soap (Acne Aid), (2) apply a hot facial pack with a washcloth, and (3) apply the assigned formulations.…”