Topical anti-inflammatory, gastroprotective and antioxidant effects of the essential oil of Lippia sidoides Cham. leaves

Monteiro, Maurílio de Abreu; Leite, Ana Karine Rocha de Melo; Bertini, Luciana Medeiros; Morais, Selene Maia de; Nunes-Pinheiro, Diana Célia Sousa

doi:10.1016/j.jep.2006.11.036

Cited by 74 publications

(53 citation statements)

References 27 publications

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“…and triterpenoids produced significant antiinflammatory activities (Silva et al, 2005). The obtained anti-inflammatory results are in line with other previous studies in family Verbenaceae (Shukla et al, 2011;Amir et al, 2011;Krishnaraju et al, 2009;Monteiro et al, 2007; Penido et al, 2006; Abena et al, 2003). The anti-pyretic activity of TMEL and its fractions have been evaluated by causing reduction in yeast-induced pyrexia (Table 6).…”

Section: Resultssupporting

confidence: 87%

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Mohammed¹,

Hamed²,

Khalil³

et al. 2016

J. Med. Plants Res.

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Chromatographic investigation of the Citharexylum quadrangulare leaves led to isolation of nine compounds viz., stigmasterol (1), β-sitosterol (2), oleanolic acid (3), duranterectoside B (4), durantoside I (5), cirsimaritin 4'-O-β-D-glucopyranoside (6), 5-deoxypulchelloside (7), lamiide (8) and cirsimaritin 4'-O-β-D-glucopyranoside 4"-sodium sulphate (9). The compounds (1, 3 and 4) were isolated for the first time from genus Citharexylum. The structures of the isolated compounds were determined by interpretation of their spectroscopical data and comparison with published literature. The aqueous fraction exhibited the most significant anti-inflammatory activity. Its effect was more potent than the reference drug. While, the most significant anti-pyretic sample was the total methanol extract. Also, it showed a gastroprotective activity with preventive index (78%). Finally, the ethyl acetate fraction demonstrated a significant decrease in blood glucose level on hyperglycemic alloxaned rats.

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Section: Resultssupporting

confidence: 87%

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Mohammed¹,

Hamed²,

Khalil³

et al. 2016

J. Med. Plants Res.

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“…Several species are used in folk medicine as an alternative to currently used drugs due to their known analgesic, anti-inflammatory, antipyretic, sedative, antifungal, antihypertensive, diuretic, larvicidal, antimicrobial, antiviral, molluscicidal, antimalarial, Chemical composition of the essential oil and hexanic fraction of Lippia and Lantana species antispasmodic, anticonvulsant and stimulant activities (Valentin et al, 1995;Pascual et al, 2001;Abena et al, 1998;Monteiro et al, 2007). Concerning the chemical and pharmacological studies, Lippia alba (Mill.)…”

Section: Introductionmentioning

confidence: 99%

Chemical composition of the essential oil and hexanic fraction of Lippia and Lantana species

Silva¹,

Viccini²,

Singulani³

et al. 2010

Rev. bras. farmacogn.

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RESUMO: "Composição química do óleo essencial e fração hexânica de espécies de Lippia e Lantana". Foi realizada a comparação entre dois métodos de extração dos compostos voláteis obtidos de seis espécies de Verbenaceae, coletadas na Serra do Cipó, Minas Gerais, Brasil. Os óleos essenciais e as frações hexanica obtidos das folhas de duas espécies de Lantana e quatro espécies de Lippia, coletadas em duas diferentes estações do ano, foram analisados por CG/EM. Grande número de constituintes foi identificado nas amostras oriundas dos dois métodos de extração e o componente majoritário para a maior parte das espécies foi o β-cariofileno, seguido pelo germacreno D, biciclogermacreno e α-pineno. Para os dois gêneros estudados, foram observadas pequenas diferenças na composição do óleo essencial e fração hexânica. Esses resultados sugerem que a análise da fração hexânica pode ser usada para identificar os componentes voláteis majoritários dessas espécies, além de ser uma técnica alternativa para a análise dos compostos voláteis presentes no óleo essencial, uma vez que ambos mostraram composição similar.Unitermos: Lippia, Lantana, Verbenaceae, óleo essencial, fração hexânica, CG/EM. ABSTRACT:A comparison between two extraction approaches of volatiles compounds from six species of Verbenaceae collected at Serra do Cipó, Minas Gerais, Brazil was done. The essential oil and hexanic fraction of leaves from two Lantana and four Lippia species collected in two different seasons were analyzed by GC/MS. Among various identified compounds from both extraction methods the majority of species showed major amounts of β-caryophyllene followed by germacrene D, bicyclogermacrene and α-pinene. Few differences were observed between the composition of essential oil and the hexanic fraction regarding the two studied genera. These results suggest that the analysis of hexanic fraction can be used, as an alternative way, to analyze the volatile compounds of the essential oil.

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“…It has been previously tested against Aedes aegypti (CARVALHO et al, 2003;CAVALCANTI et al, 2004), Haemonchus contortus, Syphacia obvelata and Aspiculuris tetraptera (CAMURÇA-VASCONCELOS et al, 2007) and has proven anti-inflammatory, gastroprotective, antioxidant (MONTEIRO et al, 2007) and anti-fungi activities (FONTENELLE et al, 2007). C. reticulata oleoresin, commonly called, óleo de Copaíba in Portuguese, belongs to the family Fabaceae.…”

Section: Introductionmentioning

confidence: 99%

In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi

Rondon

Beviláqua

Accioly

et al. 2012

Rev. Bras. Parasitol. Vet.

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The increased incidence of visceral leishmaniasis (VL) in Brazil is due to a lack of effective disease control measures. In addition to that, no effective treatment exists for canine VL in response to synthetic drugs. Thus, the objective of this study was to evaluate the effect of the essential oils of Coriandrum sativum and Lippia sidoides, and oleoresin from Copaifera reticulata, on Leishmania chagasi promastigotes and amastigotes. We also examined the toxicity of these treatments on the murine monocyte cell line RAW 264.7. To determine the IC50 a MTT test (3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) was performed on promastigotes, and an in situ ELISA assay was conducted on amastigotes. Here, we demonstrate that oleoresin from C. reticulata was effective against both promastigotes (IC50 of 7.88 µg.mL -1 ) and amastigotes (IC50 of 0.52 µg.mL -1 ), and neither of the two treatments differed significantly (p > 0.05) from pentamidine (IC50 of 2.149 µg.mL -1 ) and amphotericin B (IC50 of 9.754 µg.mL -1 ). Of the three plant oils tested, only oleoresin showed no toxicity toward monocyte, with 78.45% viability after treatment. Inhibition of promastigote and amastigote growth and the lack of cytotoxicity by C. reticulata demonstrate that oleoresin may be a viable option for analyzing the in vivo therapeutic effects of leishmanicidal plants Keywords: Leishmanicidal plants, oils, cytotoxicity, amastigotes, promastigotes, Leishmania chagasi. ResumoO aumento na incidência da Leishmaníase Visceral (LV) no Brasil deve-se à ineficácia das medidas de controle da doença. Além disso, não há tratamento efetivo para LV canina com drogas sintéticas. Assim, o objetivo deste trabalho foi avaliar o efeito dos óleos essenciais de Coriandrum sativum e de Lippia sidoides e do óleo-resina de Copaifera reticulata sobre promastigotas e amastigotas de Leishmania chagasi e analisar o grau de toxicidade sobre células monocíticas murinas RAW 264.7. Para determinar a CI50 sobre promastigotas foi usado teste MTT (brometo de 3-[4,5-dimetiltiazol-2-il]-2,5-difeniltetrazólio) e sobre amastigotas foi realizado imunoensaio in situ pela técnica de ELISA. Os resultados obtidos comprovaram que o óleo-resina de C. reticulata foi o mais eficaz contra as formas promastigotas (CI50 de 7,88 µg.mL -1 ) e amastigotas (CI50 de 0,52 µg.mL -1 ) e em nenhum dos dois testes diferiu do controle pentamidina que obteve CI50 de 2,149 µg.mL -1 , no teste sobre promastigotas, e anfotericina B que obteve CI50 de 9,754 µg.mL -1 , nos testes com amastigotas (p > 0.05). Quanto à citotoxicidade apenas o óleo-resina não apresentou toxicidade com 78,45% de monócitos viáveis. Os resultados obtidos sobre promastigotas e amastigotas e a ausência de citotoxicidade do óleo-resina de C. reticulata evidenciam que este óleo-resina pode ser viável para a análise de seus efeitos terapêuticos em testes in vivo.

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Topical anti-inflammatory, gastroprotective and antioxidant effects of the essential oil of Lippia sidoides Cham. leaves

Cited by 74 publications

References 27 publications

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Phytochemical and pharmacological studies of Citharexylum quadrangulare Jacq. leaves

Chemical composition of the essential oil and hexanic fraction of Lippia and Lantana species

In vitro efficacy of Coriandrum sativum, Lippia sidoides and Copaifera reticulata against Leishmania chagasi

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