Topical Aminocaproic Acid in the Treatment of Patients With Traumatic Hyphema

Medical interventions for traumatic hyphema

“…Participants in this study were managed on an outpatient or inpatient basis and followed for seven days. One included study compared oral aminocaproic acid versus topical aminocaproic acid for the treatment of traumatic hyphema (Crouch 1997). Of 118 participants eligible for inclusion in the study, 64 participants agreed to be randomized to receive either topical aminocaproic acid (0.2 mL of 30% aminocaproic acid in 2% carboxymethylene gel applied to the inferior fornix every six hours plus oral placebo solution every four hours for five days) or oral aminocaproic acid (50 mg/kg of body weight of oral aminocaproic acid, up to 30 g per day, plus placebo gel every four hours for five days).…”

“…Eighteen of the 27 included studies reported no exclusions or losses to follow-up, and thus used ITT analyses. Of the nine studies that excluded participants from the analysis, four studies excluded only one or two participants due to an adverse effect of treatment (Crouch 1997; Kutner 1987; Palmer 1986), treatment failure (Palmer 1986), or loss of a patient’s medical record (McGetrick 1983). The remaining five studies did not conduct ITT analyses, although all reported the number of exclusions and losses to follow-up.…”

“…Results for final (short-term) VA were reported by Crouch 1997. Final VAs of 20/40 or better were attained by 20 of 29 (85.7%) participants receiving oral aminocaproic acid and by 30 of 35 (69.0%) participants receiving topical aminocaproic acid.…”

“…We did not perform meta-analysis because only one study compared oral with topical aminocaproic acid (Crouch 1997). The number of secondary hemorrhages was not statistically different between groups: one of 29 (3%) eyes in the oral group versus one of 35 (3%) eyes in the topical group (P value = 0.89).…”

“…Crouch 1997 reported that the secondary hemorrhage in the participant in the oral aminocaproic acid group occurred on day three and the secondary hemorrhage in the participant in the topical aminocaproic acid group occurred on day five.…”

Medical interventions for traumatic hyphema

“…Participants in this study were managed on an outpatient or inpatient basis and followed for seven days. One included study compared oral aminocaproic acid versus topical aminocaproic acid for the treatment of traumatic hyphema (Crouch 1997). Of 118 participants eligible for inclusion in the study, 64 participants agreed to be randomized to receive either topical aminocaproic acid (0.2 mL of 30% aminocaproic acid in 2% carboxymethylene gel applied to the inferior fornix every six hours plus oral placebo solution every four hours for five days) or oral aminocaproic acid (50 mg/kg of body weight of oral aminocaproic acid, up to 30 g per day, plus placebo gel every four hours for five days).…”

“…Eighteen of the 27 included studies reported no exclusions or losses to follow-up, and thus used ITT analyses. Of the nine studies that excluded participants from the analysis, four studies excluded only one or two participants due to an adverse effect of treatment (Crouch 1997; Kutner 1987; Palmer 1986), treatment failure (Palmer 1986), or loss of a patient’s medical record (McGetrick 1983). The remaining five studies did not conduct ITT analyses, although all reported the number of exclusions and losses to follow-up.…”

“…Results for final (short-term) VA were reported by Crouch 1997. Final VAs of 20/40 or better were attained by 20 of 29 (85.7%) participants receiving oral aminocaproic acid and by 30 of 35 (69.0%) participants receiving topical aminocaproic acid.…”

“…We did not perform meta-analysis because only one study compared oral with topical aminocaproic acid (Crouch 1997). The number of secondary hemorrhages was not statistically different between groups: one of 29 (3%) eyes in the oral group versus one of 35 (3%) eyes in the topical group (P value = 0.89).…”

“…Crouch 1997 reported that the secondary hemorrhage in the participant in the oral aminocaproic acid group occurred on day three and the secondary hemorrhage in the participant in the topical aminocaproic acid group occurred on day five.…”

Medical interventions for traumatic hyphema

“…Participants in this study were managed on an outpatient or inpatient basis and followed for seven days. One included study compared oral aminocaproic acid versus topical aminocaproic acid for the treatment of traumatic hyphema (Crouch 1997). Of 118 participants eligible for inclusion in the study, 64 participants agreed to be randomized to receive either topical aminocaproic acid (0.2 mL of 30% aminocaproic acid in 2% carboxymethylene gel applied to the inferior fornix every six hours plus oral placebo solution every four hours for five days) or oral aminocaproic acid (50 mg/kg of body weight of oral aminocaproic acid, up to 30 g per day, plus placebo gel every four hours for five days).…”

“…Eighteen of the 27 included studies reported no exclusions or losses to follow-up, and thus used ITT analyses. Of the nine studies that excluded participants from the analysis, four studies excluded only one or two participants due to an adverse effect of treatment (Crouch 1997; Kutner 1987; Palmer 1986), treatment failure (Palmer 1986), or loss of a patient’s medical record (McGetrick 1983). The remaining five studies did not conduct ITT analyses, although all reported the number of exclusions and losses to follow-up.…”

“…Results for final (short-term) VA were reported by Crouch 1997. Final VAs of 20/40 or better were attained by 20 of 29 (85.7%) participants receiving oral aminocaproic acid and by 30 of 35 (69.0%) participants receiving topical aminocaproic acid.…”

“…We did not perform meta-analysis because only one study compared oral with topical aminocaproic acid (Crouch 1997). The number of secondary hemorrhages was not statistically different between groups: one of 29 (3%) eyes in the oral group versus one of 35 (3%) eyes in the topical group (P value = 0.89).…”

“…Crouch 1997 reported that the secondary hemorrhage in the participant in the oral aminocaproic acid group occurred on day three and the secondary hemorrhage in the participant in the topical aminocaproic acid group occurred on day five.…”

Medical interventions for traumatic hyphema

“…Participants in this study were managed on an outpatient or inpatient basis and followed for seven days. One included study compared oral aminocaproic acid versus topical aminocaproic acid for the treatment of traumatic hyphema (Crouch 1997). Of 118 participants eligible for inclusion in the study, 64 participants agreed to be randomized to receive either topical aminocaproic acid (0.2 mL of 30% aminocaproic acid in 2% carboxymethylene gel applied to the inferior fornix every six hours plus oral placebo solution every four hours for five days) or oral aminocaproic acid (50 mg/kg of body weight of oral aminocaproic acid, up to 30 g per day, plus placebo gel every four hours for five days).…”

“…Eighteen of the 27 included studies reported no exclusions or losses to follow-up, and thus used ITT analyses. Of the nine studies that excluded participants from the analysis, four studies excluded only one or two participants due to an adverse effect of treatment (Crouch 1997; Kutner 1987; Palmer 1986), treatment failure (Palmer 1986), or loss of a patient’s medical record (McGetrick 1983). The remaining five studies did not conduct ITT analyses, although all reported the number of exclusions and losses to follow-up.…”

“…Results for final (short-term) VA were reported by Crouch 1997. Final VAs of 20/40 or better were attained by 20 of 29 (85.7%) participants receiving oral aminocaproic acid and by 30 of 35 (69.0%) participants receiving topical aminocaproic acid.…”

“…We did not perform meta-analysis because only one study compared oral with topical aminocaproic acid (Crouch 1997). The number of secondary hemorrhages was not statistically different between groups: one of 29 (3%) eyes in the oral group versus one of 35 (3%) eyes in the topical group (P value = 0.89).…”

“…Crouch 1997 reported that the secondary hemorrhage in the participant in the oral aminocaproic acid group occurred on day three and the secondary hemorrhage in the participant in the topical aminocaproic acid group occurred on day five.…”