Archives of Dermatology
 1996
DOI: 10.1001/archderm.132.6.631
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Topical 8% glycolic acid and 8% L-lactic acid creams for the treatment of photodamaged skin. A double-blind vehicle-controlled clinical trial

M. J. Stiller1
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Cited by 52 publications

(45 citation statements)
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“…The consistency in improvements in skin condition for all body sites implies the cosmetic oil can dramatically improve the signs of photodamaged skin. Similar effects can be also observed from the emulsion‐based vehicle treatment groups for other reports, but this study compares the improvements in photodamage to a no‐treatment control group for the first time. As can be observed cumulative improvements are found with increasing treatment on all body sites.…”
Section: Discussionsupporting
confidence: 83%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The consistency in improvements in skin condition for all body sites implies the cosmetic oil can dramatically improve the signs of photodamaged skin. Similar effects can be also observed from the emulsion‐based vehicle treatment groups for other reports, but this study compares the improvements in photodamage to a no‐treatment control group for the first time. As can be observed cumulative improvements are found with increasing treatment on all body sites.…”
Section: Discussionsupporting
confidence: 83%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…A marked biologic effect was claimed in the epidermis (acanthosis) and dermis (collagen and glycosaminoglycan increase) after a 3-week treatment at various concentrations and pH [15]. By contrast, other studies only indicated modest effects of α-hydroxy acids upon living structures of the skin [7, 18]. Clearly the present results obtained from a randomized, placebo-controlled, double-blind study support the latter conclusions.…”
Section: Discussionsupporting
confidence: 73%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…However, these beneficial effects were observed only after 10 weeks of treatment. In a clinical trial, glycolic acid 8% improved the overall photodamage score and reduced the degree of sallowness; this clinical benefit was obtained after 22 weeks of daily treatment 15 . Therefore, there is no evidence of a clinical efficacy in skin aging in the short term for the compounds assessed in this trial.…”
Section: Discussionmentioning
confidence: 84%
“…In a clinical trial, glycolic acid 8% improved the overall photodamage score and reduced the degree of sallowness; this clinical benefit was obtained after 22 weeks of daily treatment. 15 Therefore, there is no evidence of a clinical efficacy in skin aging in the short term for the compounds assessed in this trial. There are very few products containing a fixed combination of both retinoic acid and glycolic acid.…”
Section: Discussionmentioning
confidence: 95%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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