Top quality embryos at day 2: a prerequisite for single blastocyst transfer? An observational cohort study in women under 36

Guérif, Fabrice; Lemseffer, M.; Blanchard, Milène; Royère, Dominique

doi:10.1007/s10815-009-9345-3

Cited by 18 publications

(11 citation statements)

References 34 publications

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“…In fact, both inner cell mass and the trophectoderm could be evaluated precisely in this last group (Gardner and Schoolcraft, 1999). In our IVF centre, we routinely transfer a single blastocyst to couples undertaking their first or second IVF attempt, regardless of embryo morphology on day 2 (Guerif et al, 2009). Therefore, although the number of transfers leading to a pregnancy after transfer of a morphologically poor blastocyst (n = 141) was four times lower than transfer of a morphologically good/fair blastocyst (n = 567), the number of participants remained significantly higher compared with the group in the study by Oron et al (2014b) (n = 23).…”

Section: Discussionmentioning

confidence: 99%

Obstetric and perinatal outcomes of singletons after single blastocyst transfer: is there any difference according to blastocyst morphology?

Bouillon¹,

Celton²,

Kassem³

et al. 2017

Reproductive BioMedicine Online

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A strong correlation between blastocyst morphology and implantation has been shown by many studies. The consequences and effects of assisted reproductive techniques on children's short and long-term health have always been a source of discussion. The obstetric and perinatal outcome of singletons according to blastocyst morphology has rarely been evaluated. The aim of this observational study is to determine whether a relationship exists between blastocyst morphology and obstetric and perinatal outcomes. A total of 799 singleton clinical pregnancies were analysed after transfer of a single fresh blastocyst on day 5 between 2006 and 2013. Blastocysts were divided into four groups based on their morphology on day 5: group 1 = good morphology blastocysts; group 2 = fair morphology blastocysts; group 3 = poor morphology blastocysts and group 4 = early (B1/B2) blastocysts. Obstetric and perinatal outcomes were compared between the four groups. After adjustment for some confounding variables, main obstetric and perinatal outcomes after transfer of blastocysts with poor morphological characteristics were not associated with increased adverse obstetric and perinatal events. Sex ratio was significantly higher in group 1 compared with groups 2, 3 and 4, and in Group 2 compared with Group 3 (P < 0.001) even after adjustment (P < 0.05).

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Section: Discussionmentioning

confidence: 99%

Obstetric and perinatal outcomes of singletons after single blastocyst transfer: is there any difference according to blastocyst morphology?

Bouillon¹,

Celton²,

Kassem³

et al. 2017

Reproductive BioMedicine Online

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“…All embryos were graded (Grades 1-5 from best to worst) on day three for the assessment of embryo quality from cleavage to differentiation. 13 Grade 1: embryos with evenly sized blastomeres and no fragmentation, grade 2: embryos with uneven or irregularly shaped blastomere/fragmentation (no more than 10%), grade 3, 4 and 5 embryos with fragmentation ≥25% 50% and 75% respectively and unequal blastomeres.…”

Section: Treatment Protocolmentioning

confidence: 99%

Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

Rehman

Mustafa

Hoor

et al. 2015

Int J Reprod Contracept Obstet Gynecol

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Background: We aimed to estimate pregnancy outcome after ICSI in terms of oocyte parameters, embryo quality, endometrial thickness, hormone and cytokine levels in women stratified on the basis of follicular output rate (FORT). Methods: Quasi experimental design was carried out after approval from "Ethical review board of Islamabad clinic serving infertile couples" from July 2010 to August 2013. One thousand and fifty females were selected with the criteria of age between 21-40 years, infertility of more than 2 years, body mass index of 18-35 kg/m 2 , menstrual cycle of 25 ± 7 days, both ovaries present with normal uterine cavity, serum FSH levels less than 8 IU/ml and normal thyroid-stimulating hormone levels. Females on short agonist or antagonist protocol with diagnosis of polycystic ovarian syndrome, fibroids or in their male partner sperms retrieved by testicular biopsy were excluded from the study. Down regulation of ovaries was followed by controlled ovarian stimulation, Ovulation Induction (OI), oocyte pick up, in vitro fertilization, Embryo Transfer (ET) and confirmation of pregnancy was done by serum beta hCG of more than 25 mIU/ml and cardiac activity on trans vaginal scan. Enzyme linked immuno sorbent assay was used for peak and mid luteal estradiol (E2), progesterone (P) and interleukin I-β estimation on OI and ET days respectively. FORT (ratio of preovulatory follicle count to antral follicle count × 100 on OI day) stratified females into low under the 33 rd percentile, medium between the 33 rd and the 67 th percentile and high above the 67 th percentile. Characteristics of groups were compared by one way analysis of variance. Results: Females 276 (33%), 288 (34%) and 282 (33%) comprised of low, medium and high FORT groups respectively. The number of retrieved, mature and fertilized oocytes, cleaved embryos, endometrial thickness and number of gestational sacs in the high FORT group was significantly high (P <0.001). High peak and midluteal E2 (P = 0.0025, 0.0001), low P (P = 0.0001) and high peak interleukin-1β (P = 0.0001) was observed in high FORT in comparison with medium FORT with resultant greater number of clinical pregnancies 183 (65%). Conclusions: The FORT in non PCOS patients may reflect good reproductive outcome after ICSI with maximum clinical pregnancies in high FORT group.

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“…Dans le cadre des politiques de transfert d'un seul embryon, la culture prolongé e pré sente un inté rêt majeur [22]. L'aspect morphologique pré coce des embryons n'apporte pas d'aide à la dé cision du blastocyste à transfé rer : aucune diffé rence n'a é té observé entre les blastocystes implanté s et non implanté s selon leurs caractè res morphologiques à J2 [23,24]. On peut donc en dé duire que si la politique du centre d'AMP est la culture prolongé e systé matique, il n'est pas utile d'observer les embryons aux stades J2/J3.…”

Section: Aux Deuxie`me Et Troisie`me Jours Post Ponction (Stade J2/j3)unclassified

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Belaïsch-Allart

Mayenga

Grzegorczyk-Martin

et al. 2012

Gynécologie Obstétrique & Fertilité

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Top quality embryos at day 2: a prerequisite for single blastocyst transfer? An observational cohort study in women under 36

Cited by 18 publications

References 34 publications

Obstetric and perinatal outcomes of singletons after single blastocyst transfer: is there any difference according to blastocyst morphology?

Obstetric and perinatal outcomes of singletons after single blastocyst transfer: is there any difference according to blastocyst morphology?

Importance of estimation of Follicular output rate (FORT) in females assisted by intracytoplasmic sperm injection

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