Tooth extraction in two patients who had a congenital deficiency of factor XIII

Replacement of Factor XIII in an 89‐year‐old patient with persistent post‐extraction bleeding*

“…Patients with oral cancer or hematological diseases are common in reports on bleeding and insufficient healing after tooth extraction, 12–15 while only few reports mention Factor XIII deficiency. The reports concerning Factor XIII are studies of tooth extraction in young patients with congenital Factor XIII deficiency 16–18 . So far there has been no experience of unusual bleeding such as seen in this case, and there are no reports of elderly patients with Factor XIII deficiency following tooth extraction.…”

Replacement of Factor XIII in an 89‐year‐old patient with persistent post‐extraction bleeding*

“…Patients with oral cancer or hematological diseases are common in reports on bleeding and insufficient healing after tooth extraction, 12–15 while only few reports mention Factor XIII deficiency. The reports concerning Factor XIII are studies of tooth extraction in young patients with congenital Factor XIII deficiency 16–18 . So far there has been no experience of unusual bleeding such as seen in this case, and there are no reports of elderly patients with Factor XIII deficiency following tooth extraction.…”

Factor XIII Deficiency: Laboratory, Molecular, and Clinical Aspects

“…Despite significant advances in laboratory diagnosis, understanding of molecular mechanisms, and therapeutic approaches for FXIII deficiency, personalized management remains the optimal strategy for improving replacement therapy outcomes and patients' quality of life. However, the ultra-rare nature of the disorder limits the available scientific evidence needed for implementing such personalized Table 5 Therapeutic options and regimens in patients with factor XIII deficiency 7,39,78,83,[87][88][89]92,93…”

“…83 For dental extraction, a preoperative dose of 250 to 500 IU plasma-derived FXIII concentrate followed by a second dose of 250 IU was successfully used. 87 In a recent study, the authors suggested to keep the FXIII levels at 50% in major surgeries and the goal should be 100% for complicated and prolonged surgeries. 88 It seems that a dose of 40 IU/kg is sufficient to increase FXIII levels above 50%, which is sufficient for most major surgical procedures.…”

“…Therapeutic options and regimens in patients with factor XIII deficiency7,39,78,83,[87][88][89]92,93 …”

Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing

“…The management of FXIII deficiency includes regular prophylaxis [185] with replacement therapy to increase the amount of FXIII in plasma by administering cryoprecipitate, fresh frozen plasma (FFP) [186], heat inactivated concentrate or recombinant FXIII-A 2 (rFXIII-A 2 ) therapy [187]. FXIII has relatively long half-life (~9 days), making it suitable for routine prophylactic treatment given around every 4 weeks [188].…”

Replacement of Factor XIII in an 89‐year‐old patient with persistent post‐extraction bleeding*

“…Patients with oral cancer or hematological diseases are common in reports on bleeding and insufficient healing after tooth extraction, 12–15 while only few reports mention Factor XIII deficiency. The reports concerning Factor XIII are studies of tooth extraction in young patients with congenital Factor XIII deficiency 16–18 . So far there has been no experience of unusual bleeding such as seen in this case, and there are no reports of elderly patients with Factor XIII deficiency following tooth extraction.…”

Factor XIII Deficiency: Laboratory, Molecular, and Clinical Aspects

“…Despite significant advances in laboratory diagnosis, understanding of molecular mechanisms, and therapeutic approaches for FXIII deficiency, personalized management remains the optimal strategy for improving replacement therapy outcomes and patients' quality of life. However, the ultra-rare nature of the disorder limits the available scientific evidence needed for implementing such personalized Table 5 Therapeutic options and regimens in patients with factor XIII deficiency 7,39,78,83,[87][88][89]92,93…”

“…83 For dental extraction, a preoperative dose of 250 to 500 IU plasma-derived FXIII concentrate followed by a second dose of 250 IU was successfully used. 87 In a recent study, the authors suggested to keep the FXIII levels at 50% in major surgeries and the goal should be 100% for complicated and prolonged surgeries. 88 It seems that a dose of 40 IU/kg is sufficient to increase FXIII levels above 50%, which is sufficient for most major surgical procedures.…”

“…Therapeutic options and regimens in patients with factor XIII deficiency7,39,78,83,[87][88][89]92,93 …”

Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing

“…The management of FXIII deficiency includes regular prophylaxis [185] with replacement therapy to increase the amount of FXIII in plasma by administering cryoprecipitate, fresh frozen plasma (FFP) [186], heat inactivated concentrate or recombinant FXIII-A 2 (rFXIII-A 2 ) therapy [187]. FXIII has relatively long half-life (~9 days), making it suitable for routine prophylactic treatment given around every 4 weeks [188].…”

Replacement of Factor XIII in an 89‐year‐old patient with persistent post‐extraction bleeding*

“…Patients with oral cancer or hematological diseases are common in reports on bleeding and insufficient healing after tooth extraction, 12–15 while only few reports mention Factor XIII deficiency. The reports concerning Factor XIII are studies of tooth extraction in young patients with congenital Factor XIII deficiency 16–18 . So far there has been no experience of unusual bleeding such as seen in this case, and there are no reports of elderly patients with Factor XIII deficiency following tooth extraction.…”

Factor XIII Deficiency: Laboratory, Molecular, and Clinical Aspects

“…Despite significant advances in laboratory diagnosis, understanding of molecular mechanisms, and therapeutic approaches for FXIII deficiency, personalized management remains the optimal strategy for improving replacement therapy outcomes and patients' quality of life. However, the ultra-rare nature of the disorder limits the available scientific evidence needed for implementing such personalized Table 5 Therapeutic options and regimens in patients with factor XIII deficiency 7,39,78,83,[87][88][89]92,93…”

“…83 For dental extraction, a preoperative dose of 250 to 500 IU plasma-derived FXIII concentrate followed by a second dose of 250 IU was successfully used. 87 In a recent study, the authors suggested to keep the FXIII levels at 50% in major surgeries and the goal should be 100% for complicated and prolonged surgeries. 88 It seems that a dose of 40 IU/kg is sufficient to increase FXIII levels above 50%, which is sufficient for most major surgical procedures.…”

“…Therapeutic options and regimens in patients with factor XIII deficiency7,39,78,83,[87][88][89]92,93 …”

Factor XIII-A: An Indispensable “Factor” in Haemostasis and Wound Healing

“…The management of FXIII deficiency includes regular prophylaxis [185] with replacement therapy to increase the amount of FXIII in plasma by administering cryoprecipitate, fresh frozen plasma (FFP) [186], heat inactivated concentrate or recombinant FXIII-A 2 (rFXIII-A 2 ) therapy [187]. FXIII has relatively long half-life (~9 days), making it suitable for routine prophylactic treatment given around every 4 weeks [188].…”