Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

Chen, Chung‐Jen; Michaelis, Martin; Hsu, Hseng Kuang; Tsai, Chin Chuan; Yang, Kun‐Lin; Wu, Yang Chang; Cinatl, Jindrich; Doerr, Hans Wilhelm

doi:10.1016/j.jep.2008.07.048

Cited by 150 publications

(95 citation statements)

References 12 publications

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“…Flavonoids, [26][27][28] limonoids, 10,17,29 and triterpenoids have been identified from the leaves and stems of this plant. The reported biological activities of C. sinensis include antioxidant activity, 19,30 antitumor effects, [11][12][13]24 inhibition of virus replication, 14 and hypoglycemic effects. 15 However, there has been little research on the activation or regulation of expression of antioxidant enzymes by C. sinensis.…”

Section: Sod Reacts With Omentioning

confidence: 99%

“…[11][12][13] Recent studies have also demonstrated the hypoglycemic and antiviral effects of the extract of C. sinensis leaves. 14,15 Recently, our group reported that the dichloromethane (DCM)-soluble fraction from C. sinensis significantly inhibits lipopolysaccharide-induced nitric oxide and ROS production as well as the expressions of inducible nitric oxide synthase and cyclooxygenase 2 via an MAPK pathway. 16 Other studies have identified various phytochemicals from this plant, including flavonoids, limonoids and terpenoids.…”

Section: Introductionmentioning

confidence: 99%

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Stimulation of Activity and Expression of Antioxidant Enzymes by Solvent Fractions and Isolated Compound from Cedrela sinensis Leaves in HepG2 Cells

Bak

Jeong

Kang

et al. 2011

Journal of Medicinal Food

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Cedrela sinensis has been widely used in traditional Oriental medicine to treat a variety of diseases. However, little is known about the cellular actions by which this plant mediates its antioxidant effects. In this study, activity-guided fractionations of C. sinensis leaves were performed using column chromatographic techniques as well as biological assays with HepG2 cells. The ethanol (95%) extract of C. sinensis leaves was sequentially extracted with hexane, chloroform, ethyl acetate (EtOAc), butanol, and water, and the fractions were screened for their antioxidant potentials for scavenging radicals as well as inducing antioxidant enzyme activity and expression. The most potent antioxidant EtOAc fraction was further separated using chromatographic techniques including open column and high-performance liquid chromatography. Compound 1 from the EtOAc fraction showed strong radical scavenging activity with a 50% scavenging concentration value close to that of ascorbic acid and induced both the activity and expressions of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione peroxidase. Inhibitory effects on the phosphorylations of upstream mitogen-activated protein kinases such as c-Jun N-terminal kinase, extracellular signal-regulated kinase, and p38 were also observed after treatments with compound 1. Compound 1 was identified as quercitrin by (1)H- and (13)C-nuclear magnetic resonance techniques. Taken together, our findings demonstrated for the first time that C. sinensis leaves appear to be a useful source of a cytoprotective and chemopreventive agent that can stimulate the activity and expression of crucial antioxidant enzymes in cells.

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Section: Sod Reacts With Omentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Stimulation of Activity and Expression of Antioxidant Enzymes by Solvent Fractions and Isolated Compound from Cedrela sinensis Leaves in HepG2 Cells

Bak

Jeong

Kang

et al. 2011

Journal of Medicinal Food

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“…Importantly, almost all parts of T. sinensis including seed, bark, root bark, petioles, and leaves have a number of traditional Chinese medicinal values (for example: used as febrifuge, astringent, carminative, and used for enteritis and dysentery treatments) (Xien, 1996;Edmonds and Staniforth, 1998). More recently, various other biological values discovered from the T. sinensis leaf extracts have been reported: anti-cancer (Chang et al, 2002;Wang et al, 2010;Yang et al, 2010), antiinflammatory (Yang et al, 2006), anti-diabetes (Hsu et al, 2003), anti-neoplastic effect (Chia et al, 2010), and inhibitory effects on Leydig cell steroidogenesis (Poon et al, 2005), severe acute respiratory syndromes and coronavirus replication (Chen et al, 2008), and antitumor (Yang et al, 2013). In addition, T. sinensis trunk is a good source of hardwood (Edmonds and Staniforth, 1998).…”

Section: Introductionmentioning

confidence: 99%

Genetic diversity of Toona sinensis Roem in China revealed by ISSR and SRAP markers

et al. 2016

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ABSTRACT. Toona sinensis Roem has an important value as a type of traditional vegetable and Chinese medicinal herb, and is also a valuable source of wood in China. In this study, we used the inter-simple sequence repeat (ISSR) and sequence-related amplified polymorphism (SRAP) markers to assess the level and pattern of genetic diversity in five domesticated T. sinensis populations in China. Our results indicated a relatively low level of genetic diversity both at species (Hs = 0.1662, 0.2098, respectively) and population levels (Hs = 0.0978, 0.1145, respectively). Molecular variance analyses revealed a relatively high degree of differentiation among populations (G ST = 0.3901, 0.4498), and low levels of gene flow (N m = 0.7816 and 0.6116). We divided the five populations into two groups by cluster analysis: group one consists of populations collected from the south part of China (e.g., Yuxi, Yunan Province and Zuanjiang, Chongqing Municipality), and group two contains those cultivated in north part of China (e.g., Hengshui, Hebei Province, Jinan and Rizhao, Shandong Province). The correlation of genetic relationships among populations fits well with their geographical distribution (Mantel test; r = 0.7236 and 0.6789, respectively). Asexual propagation, limited gene flow and geographic isolation are most likely the key factors associated with the observed genetic structure of T. sinensis grown in China. The present study indicated that both ISSR and SRAP markers were effective and reliable for assessing the degree of T. sinensis genetic variations.

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“…Indeed the plant possesses many biological functions such as antitumor activity [2], antioxidant capacity [3], and anti-inflammatory properties [4]. It is also used for treating severe acute respiratory syndrome [5], and for improving hyperglycemia and dyslipidemia [6]. The young leaves of TS are popular in traditional Chinese medicines and have been used for long as a safe vegetable source [7].…”

Section: Introductionmentioning

confidence: 99%

Anti-cancer and antioxidant properties of phenolics isolated from<i> Toona sinensis</i> A Juss acetone leaf extract

Shan¹,

Huang²,

Zhang³

et al. 2016

Trop. J. Pharm Res

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Toona sinensis Roem tender leaf extract inhibits SARS coronavirus replication

Abstract: This paper reports for the first time that extract from a vegetable, the tender leaf of Toona sinensis Roem, can inhibit SARS-CoV in vitro. Thererfore, the tender leaf of Toona sinensis Roem may be an important resource agninst SARS-CoV.

Cited by 150 publications

References 12 publications

Stimulation of Activity and Expression of Antioxidant Enzymes by Solvent Fractions and Isolated Compound from Cedrela sinensis Leaves in HepG2 Cells

Stimulation of Activity and Expression of Antioxidant Enzymes by Solvent Fractions and Isolated Compound from Cedrela sinensis Leaves in HepG2 Cells

Genetic diversity of Toona sinensis Roem in China revealed by ISSR and SRAP markers

Anti-cancer and antioxidant properties of phenolics isolated from<i> Toona sinensis</i> A Juss acetone leaf extract

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