Tonic pain and continuous EEG: Prediction of subjective pain perception by alpha-1 power during stimulation and at rest

Nir, Rony-Reuven; Sinai, Alon; Moont, Ruth; Harari, Eyal; Yarnitsky, David

doi:10.1016/j.clinph.2011.08.006

Cited by 108 publications

(127 citation statements)

References 59 publications

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“…The present observation of changes of alpha, beta and gamma oscillations during longer-lasting pain is in agreement with previous studies which found suppressions of alpha and beta oscillations (Giehl et al, 2014, Gram et al, 2015, Huishi Zhang et al, 2016, Nir et al, 2012, Peng et al, 2014, Shao et al, 2012) and increases of gamma oscillations (Dowman et al, 2008, Peng et al, 2014, Veerasarn and Stohler, 1992) during tonic pain. However, only a single previous study distinguished between brain processes related to stimulus intensity and pain intensity (Schulz et al, 2015).…”

Section: Discussionsupporting

confidence: 93%

Brain oscillations differentially encode noxious stimulus intensity and pain intensity

et al. 2017

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Noxious stimuli induce physiological processes which commonly translate into pain. However, under certain conditions, pain intensity can substantially dissociate from stimulus intensity, e.g. during longer-lasting pain in chronic pain syndromes. How stimulus intensity and pain intensity are differentially represented in the human brain is, however, not yet fully understood. We therefore used electroencephalography (EEG) to investigate the cerebral representation of noxious stimulus intensity and pain intensity during 10 min of painful heat stimulation in 39 healthy human participants. Time courses of objective stimulus intensity and subjective pain ratings indicated a dissociation of both measures. EEG data showed that stimulus intensity was encoded by decreases of neuronal oscillations at alpha and beta frequencies in sensorimotor areas. In contrast, pain intensity was encoded by gamma oscillations in the medial prefrontal cortex. Contrasting right versus left hand stimulation revealed that the encoding of stimulus intensity in contralateral sensorimotor areas depended on the stimulation side. In contrast, a conjunction analysis of right and left hand stimulation revealed that the encoding of pain in the medial prefrontal cortex was independent of the side of stimulation. Thus, the translation of noxious stimulus intensity into pain is associated with a change from a spatially specific representation of stimulus intensity by alpha and beta oscillations in sensorimotor areas to a spatially independent representation of pain by gamma oscillations in brain areas related to cognitive and affective-motivational processes. These findings extend the understanding of the brain mechanisms of nociception and pain and their dissociations during longer-lasting pain as a key symptom of chronic pain syndromes.

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Section: Discussionsupporting

confidence: 93%

Brain oscillations differentially encode noxious stimulus intensity and pain intensity

et al. 2017

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“…A more recent study [41] showed that prestimulus EEG oscillations in the alpha frequency band modulated the subjective perception of painful stimuli: prestimulus alpha oscillatory activities in fact assisted in predicting subjective pain perception. This notion is in line with reports indicating that decreased low-alpha brain oscillations are correlated with higher numerical pain scores collected during both resting-state and noxious conditions by the application of tonic noxious stimuli [42]. …”

Section: Discussionsupporting

confidence: 92%

Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension

Papageorgiou

Tsaltas

Koroboki

et al. 2017

International Journal of Hypertension

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Objective Essential hypertension is associated with reduced pain sensitivity of unclear aetiology. This study explores this issue using the Cold Pressor Test (CPT), a reliable pain/stress model, comparing CPT-related EEG activity in first episode hypertensives and controls. Method 22 untreated hypertensives and 18 matched normotensives underwent 24-hour ambulatory blood pressure monitoring (ABPM). EEG recordings were taken before, during, and after CPT exposure. Results Significant group differences in CPT-induced EEG oscillations were covaried with the most robust cardiovascular differentiators by means of a Canonical Analysis. Positive correlations were noted between ABPM variables and Delta (1–4 Hz) oscillations during the tolerance phase; in high-alpha (10–12 Hz) oscillations during the stress unit and posttest phase; and in low-alpha (8–10 Hz) oscillations during CPT phases overall. Negative correlations were found between ABPM variables and Beta2 oscillations (16.5–20 Hz) during the posttest phase and Gamma (28.5–45 Hz) oscillations during the CPT phases overall. These relationships were localised at several sites across the cerebral hemispheres with predominance in the right hemisphere and left frontal lobe. Conclusions These findings provide a starting point for increasing our understanding of the complex relationships between cerebral activation and cardiovascular functioning involved in regulating blood pressure changes.

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“…Amplitudes of EEG oscillations in theta (4-8 Hz), alpha (8-13 Hz), beta (13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30), and gamma (50-90 Hz) bands were calculated for each condition and electrode. The obtained single-epoch amplitude spectra for each condition and electrode were averaged across epochs to enhance the signal-to-noise ratio.…”

Section: Eeg Spectral Analysismentioning

confidence: 99%

“…Besides, different from pain originating from deep tissue, cutaneous pain is not dominantly encountered in clinical practice [5,6]. Currently, tonic cutaneous pain models (e.g., cold pain [7][8][9][10][11][12], tonic heat pain [13][14][15][16][17]) have been proposed to resemble clinical pain, and to investigate pain-related cortical features [5,18]. There is growing interest in elucidating the neural correlates of tonic deep pain using various physical stressors: muscular injections of capsaicin [19,20] and hypertonic saline [21].…”

Section: Introductionmentioning

confidence: 99%

Changes of gamma-band oscillatory activity to tonic muscle pain

Liu

Cai

et al. 2016

Neuroscience Letters

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Tonic pain and continuous EEG: Prediction of subjective pain perception by alpha-1 power during stimulation and at rest

Cited by 108 publications

References 59 publications

Brain oscillations differentially encode noxious stimulus intensity and pain intensity

Brain oscillations differentially encode noxious stimulus intensity and pain intensity

Brain Oscillations Elicited by the Cold Pressor Test: A Putative Index of Untreated Essential Hypertension

Changes of gamma-band oscillatory activity to tonic muscle pain

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