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citations
Cited by 1,100 publications
(931 citation statements)
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References 21 publications
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“…The variables entered in the univariate analysis included age, sex, ischaemic heart disease, LV end‐diastolic and end‐systolic diameters, LV ejection fraction, New York Heart Association functional class, previous episode of HF, systolic blood pressure, heart rate, hyponatraemia on admission, serum creatinine and BNP at discharge, and drug therapy over the clinical course. Hyponatraemia was defined as serum sodium level <135 mEq/L 13. Variables with P value <0.10 in univariate analysis, and those that had been demonstrated to be associated with all‐cause and cardiovascular mortality in HF patients by previous literature data were included in multivariate Cox proportional hazards models.…”
Section: Methodsmentioning
confidence: 99%
“…The variables entered in the univariate analysis included age, sex, ischaemic heart disease, LV end‐diastolic and end‐systolic diameters, LV ejection fraction, New York Heart Association functional class, previous episode of HF, systolic blood pressure, heart rate, hyponatraemia on admission, serum creatinine and BNP at discharge, and drug therapy over the clinical course. Hyponatraemia was defined as serum sodium level <135 mEq/L 13. Variables with P value <0.10 in univariate analysis, and those that had been demonstrated to be associated with all‐cause and cardiovascular mortality in HF patients by previous literature data were included in multivariate Cox proportional hazards models.…”
Section: Methodsmentioning
confidence: 99%
“…This is an attractive therapeutic avenue because it tackles the cause of the underlying fluid retention 11.…”
Section: Treatment Of Hyponatraemiamentioning
confidence: 99%
“…The SALT‐1 and SALT‐2 trials have shown that serum sodium can be safely improved in patients with hyponatraemia through removal of excess free water, producing additional benefits in patients’ quality of life, as measured by 12‐item Short Form General Health Survey scores 11. The prompt correction of hyponatraemia in patients with SIADH may be associated with a reduction in hospital stay 12.…”
Section: Treatment Of Hyponatraemiamentioning
confidence: 99%
“…Vasopressin receptor antagonists correct symptomatic dilutional hyponatremia resistant to conservative measures. 49 However, tolvaptan use in patients with cirrhosis has been the subject of an US Food and Drug Administration warning because of rare hepatotoxicity. Tolvaptan use is no longer endorsed by the US Food and Drug Administration, but it remains an effective means of hyponatremia treatment when other therapeutic measures fail and the risks have been considered.…”
Section: Hyponatremiamentioning
confidence: 99%