Toluidine blue uptake in potentially malignant oral lesions in vivo: Clinical and histological assessment

Gandolfo, S; Pentenero, Monica; Broccoletti, Roberto; Pagano, Mario; Carrozzo, M; Scully, Crispian

doi:10.1016/j.oraloncology.2005.06.016

Cited by 86 publications

(70 citation statements)

References 23 publications

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“…8,9 The oral rinsing protocol was: 20 s prerinse with 30 ml of 1% acetic acid; 20 s water rinse; 20 s rinse/gargle with 10 ml of TB solution; 20 s postrinse with 30 ml of 1% acetic acid (twice); a final water rinse. Only blue royal stained lesions were considered positive according to Gandolfo et al 10 TB lesions were rated as positive or negative by four experienced experts in oral medicine previously calibrated in pairs.…”

Section: Conventional Light Examination: Suspicious Lesionsmentioning

confidence: 99%

Evaluation of autofluorescence and toluidine blue in the differentiation of oral dysplastic and neoplastic lesions from non dysplastic and neoplastic lesions: a cross-sectional study

et al. 2014

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Abstract. The objective was to compare toluidine blue (TB) and autofluorescence (AF) for the detection of oral dysplasia and squamous cell carcinoma (OSCC) in clinically suspicious lesions according to conventional examination. Fifty-six clinically suspicious lesions were subjected to AF and TB examination. Data were compared using two different scenarios: in the first, mild dysplasia was considered as positive, while in the second, it was considered as negative. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV), accuracy, and concordance were calculated. AF sensitivity and specificity were 70.0 and 57.7%, respectively, while TB showed a sensitivity of 80% and a specificity of 61.5%. The sensitivity increased in the second scenario in both AF (76.5%) and TB (88.2%). The specificity decreased in AF and TB, showing the same value (51.3%). PPV was higher in TB than in AF (70.6 versus 65.6%) and similarly for NPV (72.7 versus 62.5%). In the second scenario, TB PPV was 44.1% and NPV was 90.9%; AF PPV was 40.6% and NPV was 83.3%. TB showed greater accuracy than AF in the first scenario (62.5 versus 58.9%). AF and TB are both sensitive but not specific in OSCC and dysplasia diagnosis. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Conventional Light Examination: Suspicious Lesionsmentioning

confidence: 99%

Evaluation of autofluorescence and toluidine blue in the differentiation of oral dysplastic and neoplastic lesions from non dysplastic and neoplastic lesions: a cross-sectional study

et al. 2014

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“…LDH represents a marker to cell death and tissue breakdown and its raised level often signifies a disease process [16]. CA125 is a repeating peptide epitope of the mucin MUC16 [17,18], which promotes cancer cell proliferation and inhibits anti-cancer immune responses [19][20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Utility Of Salivary CA-125 And LDH As Tumor Markers In Oral Malignancy

Yadav

Ja²,

Ar³

et al. 2018

IJCBR

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Background:The mortality and morbidity associated with oral Squamous cell carcinoma (OSCC) can be greatly reduced if tumor markers which can detect OSCC at an early stage are available. This study attempts to use saliva as the diagnostic medium to determine the correlation of salivary CA 125 and LDH in tobacco users with and without potentially malignant disorders. Changes in CA 125 and LDH level can be used as a marker in patients with and without premalignant disease and can be used as a deterrent in continuation of the habit. Aims: To assess the role of CA 125 & LDH as a tumour marker in Oral cancer patients. Materials and methods: Cross sectional observational study .Time period: December 2015 to August 2017.Study area: OPD of tertiary care hospital in pune. Total participants: 150 persons. Under non-stimulatory conditions whole saliva sample was collected from each individual and was centrifuged. The resulting supernatant was used for estimation of CA 125 and LDH levels. Results: In present study, mean Salivary LDH level was found to be lowest among cases of healthy individuals while it was highest among individuals who were diagnosed and underwent treatment for malignancy. However there was insignificant difference seen between levels of diagnosed case of oral malignancy and the ones who underwent treatment for oral malignancy. Also mean Salivary CA-125 was lowest in healthy individuals and highest in individuals diagnosed with oral malignancy and the levels were seen to be reduced significantly in the one who underwent treatment for oral malignancies than those who didn't. Conclusion: Salivary CA 125 and LDH has a role in early detection of oral malignancies and can be used as a diagnostic marker. However LDH levels are persistently raised even after treatment for oral malignancy.

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“…Abnormal areas will appear white ("aceto-white") igure 4. The light increases both the brightness and the sharpness of lesions Chemiluminescence has been found to signi icantly assist the clinician in identifying white and erythroleukoplakia lesions [39].…”

Section: Vizilite and Vizilite-plusmentioning

confidence: 99%

Promising Future in the Detection of Oral Cancer by Using Advance Screening Technology

MY¹

2016

J Oral Health Craniofac Sci

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Toluidine blue uptake in potentially malignant oral lesions in vivo: Clinical and histological assessment

Cited by 86 publications

References 23 publications

Evaluation of autofluorescence and toluidine blue in the differentiation of oral dysplastic and neoplastic lesions from non dysplastic and neoplastic lesions: a cross-sectional study

Evaluation of autofluorescence and toluidine blue in the differentiation of oral dysplastic and neoplastic lesions from non dysplastic and neoplastic lesions: a cross-sectional study

Utility Of Salivary CA-125 And LDH As Tumor Markers In Oral Malignancy

Promising Future in the Detection of Oral Cancer by Using Advance Screening Technology

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