J. Appl. Toxicol.
 1999
DOI: 10.1002/(sici)1099-1263(199903/04)19:2<93::aid-jat547>3.0.co;2-f
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Tolerance to β,β′-iminodipropionitrile (IDPN)-induced neurobehavioural and vestibular toxicity in diabetic rats

Mohammad Tariq
1
,
Haseeb A. Khan
2
,
Khalaf Al Moutaery
3
et al.
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Cited by 6 publications

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“…This discrepancy may be attributed to the differences in animal strain (Wistar vs. Long-Evans), dose of IDPN (8 3 100 vs. 3 3 400 mg/kg), analysis time post dosing (2 days vs. 4 weeks) used in our and their studies respectively. It is also important to note that DA turnover and not the DA content alone is a reliable predictor of dopaminergic status (Ogawa et al, 1990(Ogawa et al, , 1991Tariq et al, 1999). Moreover the role of dopaminergic neurotransmission in IDPN toxicity is supported by several studies demonstrating significant inhibition of IDPN-induced behavioral syndrome by DA antagonists (Cadet et al, 1987;Khan et al, 2004;Ogawa et al, 1991).…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…This discrepancy may be attributed to the differences in animal strain (Wistar vs. Long-Evans), dose of IDPN (8 3 100 vs. 3 3 400 mg/kg), analysis time post dosing (2 days vs. 4 weeks) used in our and their studies respectively. It is also important to note that DA turnover and not the DA content alone is a reliable predictor of dopaminergic status (Ogawa et al, 1990(Ogawa et al, , 1991Tariq et al, 1999). Moreover the role of dopaminergic neurotransmission in IDPN toxicity is supported by several studies demonstrating significant inhibition of IDPN-induced behavioral syndrome by DA antagonists (Cadet et al, 1987;Khan et al, 2004;Ogawa et al, 1991).…”
mentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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