Arch Gen Psychiatry
 1973
DOI: 10.1001/archpsyc.1973.04200050011002
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Tolerance and Dependence to Serotonin

Richard Jed Wyatt1
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Cited by 10 publications

(2 citation statements)
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“…Similarly in schizophrenics gross behavioural changes follow abrupt but not gradual alteration in 5-hydroxytryptophan dosage (Wyatt, Kaplan & Vaughan, 1973).…”
Section: Discussionmentioning
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Similarly in schizophrenics gross behavioural changes follow abrupt but not gradual alteration in 5-hydroxytryptophan dosage (Wyatt, Kaplan & Vaughan, 1973).…”
Section: Discussionmentioning
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Seven human subjects were given L-dopa orally to study the effect of the amount of desynchronized sleep (831). The drug produced a significant reduction in the amount of desynchronized-sleep time in all subjects, ranging from 4% to 46% below placebo baseline.…”
Section: Neuropharmacology Of Sleep Cyclementioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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