Tocolytics for preterm premature rupture of membranes

Abstract

Our review suggests there is insufficient evidence to support tocolytic therapy for women with PPROM, as there was an increase in maternal chorioamnionitis without significant benefits to the infant. However, studies did not consistently administer latency antibiotics and corticosteroids, both of which are now considered standard of care.

WITHDRAWN: Determination of The Factors Affecting The Latent Period of Periviable Premature Rupture of Membranes Cases and Evaluation of Newborn Outcomes

“…As a result of the compilations, data were obtained that the use of tocolysis increased the latent period but signi cantly increased the risk of chorioamnionitis. No signi cant difference was found in neonatal outcomes [7]. In our study, the use of tocolysis prolonged the latent period in a statistically signi cant way, but no signi cant difference was found in terms of chorioamnionitis risk and neonatal outcomes.…”

WITHDRAWN: Determination of The Factors Affecting The Latent Period of Periviable Premature Rupture of Membranes Cases and Evaluation of Newborn Outcomes

“…As a result of the compilations, data were obtained that the use of tocolysis increased the latent period but signi cantly increased the risk of chorioamnionitis. No signi cant difference was found in neonatal outcomes [7]. In our study, the use of tocolysis prolonged the latent period in a statistically signi cant way, but no signi cant difference was found in terms of chorioamnionitis risk and neonatal outcomes.…”

Does Vitamin C and Vitamin E Supplementation Prolong the Latency Period before Delivery following the Preterm Premature Rupture of Membranes? A Randomized Controlled Study

“…13,14 Fetuses with fetal inflammatory response syndrome, as a result of intra-amniotic infection and inflammation, have increased risk of severe perinatal morbidity, including RDS, perinatal sepsis, IVH, and NEC. [13][14][15][16][17][18][19][20] No significant differences in neonatal sepsis, neonatal death, RDS, NEC, or IVH grade III to IV were noted between groups in the present study. This may be due to the small sample size necessary to detect a significant difference.…”

Effect of Magnesium Sulfate Administration for Neuroprotection on Latency in Women with Preterm Premature Rupture of Membranes

“…Given that recent literature does not find sufficient evidence to support the use of tocolytics in women with PPROM, this may also reflect a change in provider practice patterns. 18 The limitations of our study warrant discussion. Our outcomes of delivery within 48 hours and 7 days were after randomization, not PPROM.…”

WITHDRAWN: Determination of The Factors Affecting The Latent Period of Periviable Premature Rupture of Membranes Cases and Evaluation of Newborn Outcomes

“…As a result of the compilations, data were obtained that the use of tocolysis increased the latent period but signi cantly increased the risk of chorioamnionitis. No signi cant difference was found in neonatal outcomes [7]. In our study, the use of tocolysis prolonged the latent period in a statistically signi cant way, but no signi cant difference was found in terms of chorioamnionitis risk and neonatal outcomes.…”

Does Vitamin C and Vitamin E Supplementation Prolong the Latency Period before Delivery following the Preterm Premature Rupture of Membranes? A Randomized Controlled Study

“…13,14 Fetuses with fetal inflammatory response syndrome, as a result of intra-amniotic infection and inflammation, have increased risk of severe perinatal morbidity, including RDS, perinatal sepsis, IVH, and NEC. [13][14][15][16][17][18][19][20] No significant differences in neonatal sepsis, neonatal death, RDS, NEC, or IVH grade III to IV were noted between groups in the present study. This may be due to the small sample size necessary to detect a significant difference.…”

Effect of Magnesium Sulfate Administration for Neuroprotection on Latency in Women with Preterm Premature Rupture of Membranes

“…Given that recent literature does not find sufficient evidence to support the use of tocolytics in women with PPROM, this may also reflect a change in provider practice patterns. 18 The limitations of our study warrant discussion. Our outcomes of delivery within 48 hours and 7 days were after randomization, not PPROM.…”

WITHDRAWN: Determination of The Factors Affecting The Latent Period of Periviable Premature Rupture of Membranes Cases and Evaluation of Newborn Outcomes

“…As a result of the compilations, data were obtained that the use of tocolysis increased the latent period but signi cantly increased the risk of chorioamnionitis. No signi cant difference was found in neonatal outcomes [7]. In our study, the use of tocolysis prolonged the latent period in a statistically signi cant way, but no signi cant difference was found in terms of chorioamnionitis risk and neonatal outcomes.…”

Does Vitamin C and Vitamin E Supplementation Prolong the Latency Period before Delivery following the Preterm Premature Rupture of Membranes? A Randomized Controlled Study

“…13,14 Fetuses with fetal inflammatory response syndrome, as a result of intra-amniotic infection and inflammation, have increased risk of severe perinatal morbidity, including RDS, perinatal sepsis, IVH, and NEC. [13][14][15][16][17][18][19][20] No significant differences in neonatal sepsis, neonatal death, RDS, NEC, or IVH grade III to IV were noted between groups in the present study. This may be due to the small sample size necessary to detect a significant difference.…”

Effect of Magnesium Sulfate Administration for Neuroprotection on Latency in Women with Preterm Premature Rupture of Membranes

“…Given that recent literature does not find sufficient evidence to support the use of tocolytics in women with PPROM, this may also reflect a change in provider practice patterns. 18 The limitations of our study warrant discussion. Our outcomes of delivery within 48 hours and 7 days were after randomization, not PPROM.…”