Tocilizumab in the treatment of eosinophilic fasciitis: Case report and literature review

Brandy-García, Anahy M.; Fernández, Sabela; Pampín-Sánchez, Rubén

doi:10.1016/j.rceng.2021.12.003

Cited by 3 publications

(2 citation statements)

References 7 publications

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“…Auch Infliximab (ein monoklonaler Antikörper gegen den Tumor-Nekrose-Faktor α) und Tocilizumab (ein humanisierter antihumaner IL-6-Rezeptor-Antikörper [IgG1]) konnten in Fallberichten zur erfolgreichen Therapie der eosinophilen Fasziitis eingesetzt werden [19]. Auch Baricitinib -ein selektiver und reversibler Inhibitor von Januskinase (JAK)1 und JAK2 -zeigte sich in einem Fallbericht über eine therapieresistente eosinophile Fasziitis erfolgreich [20,21]. In einer Fallserie konnte darüber hinaus die erfolgreiche Therapie der eosinophilen Fasziitis mit Rituximab (ein Anti-CD10-Antikörper) dargestellt werden [22].…”

Section: Eosinophile Granulozytenunclassified

Eosinophile Dermatosen

et al. 2022

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Section: Eosinophile Granulozytenunclassified

Eosinophile Dermatosen

et al. 2022

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“…Alternatively, dapsone, tacrolimus or cyclosporine may be applied. In the medical literature, there are reports of successful use of TNF-α inhibitors, such as adalimumab and etanercept or IL-6 inhibitors like tocilizumab [ 37 ] in the treatment of refractory EF. Moreover, the importance of treating the triggering factor is often emphasised.…”

Section: Introductionmentioning

confidence: 99%

Diffuse fasciitis with eosinophilia in boys: a case-based review

et al. 2023

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Diffuse fasciitis with eosinophilia (EF) is a rare condition classified as a part of the connective tissue disorders. The clinical presentation of this condition can be diverse, however the main symptoms include symmetrical swelling and hardening of distal parts of limbs accompanied by peripheral eosinophilia. The diagnostic criteria are not specified. In inconclusions cases Magnetic Resonance Imaging (MRI) and skin to muscle biopsy may be useful. The pathogenesis and ethiology remain unknown, but extensive physical exertion, certain infectious factors, such as Borrelia burgdorferi, or medications may serve as a trigger. EF affects equally women and men, mainly in their middle age, however the disease can occur at any age. The standard therapy contents gluccocorticosteroids. As a second-line treatment, methotrexate is usually chosen. In this article we compare world reports of EF in paediatric patients with the cases of two adolescent male patients recently hospitalized in the Department of Paediatric Rheumatology.

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Eosinophilic fasciitis: unraveling the clinical tapestry of a rare case and review of literature

Cherim,

Bastian,

Popp

et al. 2024

Rom J Morphol Embryol

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Eosinophilic fasciitis (EF) remains a diagnostic challenge due to its rarity and resemblance to scleroderma. This case report aims to provide a cohesive exploration of EF’s clinical nuances, emphasizing the importance of accurate diagnosis and effective management. A 52-year-old male developed bilateral forearm and calf hardening, along with erythema, pruritus, and pain four months prior to the presentation in our Clinic. The symptoms initially debuted bilaterally in the forearms and progressed to involve the calves, distal arms, and thighs. Clinical examination revealed symmetrical plaques on forearms and calves, featuring erythematous, hyper, and hypopigmented elements extending proximally, a positive “groove sign” and a moderate difficulty in knee joint flexion. Despite these findings, the patient was generally in good condition, without any other notable clinical signs. Initial laboratory findings showed slightly increased percentual eosinophil levels, elevated C-reactive protein (CRP), normal erythrocyte sedimentation rate (ESR), and negative antinuclear and scleroderma specific antibodies. Magnetic resonance imaging (MRI) demonstrated enhanced fascial signal and thickening while the fascia-muscle biopsy revealed marked edema and inflammatory lymphoplasmacytic infiltrate, consistent with the diagnosis of EF. The patient showed a favorable response to systemic corticosteroids. EF predominantly affects males aged 30 to 60 and is characterized by a sudden onset and unclear etiological factors. Differential diagnosis requires careful exclusion of scleroderma and other mimicking conditions. Diagnostic modalities such as skin-muscle biopsy and MRI reveal characteristic findings like inflammatory infiltrate and fascial thickening. Accurate diagnosis and differentiation from scleroderma are crucial, with early intervention involving glucocorticoids and immunosuppressive agents improving long-term outcomes.

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Tocilizumab in the treatment of eosinophilic fasciitis: Case report and literature review

Cited by 3 publications

References 7 publications

Eosinophile Dermatosen

Eosinophile Dermatosen

Diffuse fasciitis with eosinophilia in boys: a case-based review

Eosinophilic fasciitis: unraveling the clinical tapestry of a rare case and review of literature

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